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The Role of Mitochondria in the Metabolic Syndrome and Insulin Resistance

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Mitochondria and Their Role in Cardiovascular Disease

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Abstract

Recent studies indicate that mitochondrial function is altered in the insulin-resistant myocardium, and this contributes to complex metabolic problems, such as obesity and diabetes mellitus, factors of significant cardiovascular mortality. Mitochondrial dysfunction and uncoupling are induced by fatty acids leading to reduction of cardiac efficiency by limiting ATP production and increasing myocardial oxygen consumption. Insulin resistance is a major factor in the pathogenesis of type 2 diabetes in the elderly and age-related changes associated with increased fat accumulation and reduction in mitochondrial oxidative phosphorylation activity, indicating that an age-associated decline in mitochondrial function contributes to insulin resistance in the elderly.

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    José Marín-García M.D.

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Marín-García, J. (2013). The Role of Mitochondria in the Metabolic Syndrome and Insulin Resistance. In: Mitochondria and Their Role in Cardiovascular Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4599-9_21

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