Abstract
Musculature of the craniofacial region represents a diverse group of skeletal muscles responsible for processes underlying respiration, deglutition, speech production, vision, hearing, and the display of emotions. Together, these muscles demonstrate a remarkable degree of anatomical specialization that permits their successful engagement in behavioral functions. Because the functional demands placed upon craniofacial muscles differ substantially from those imposed upon other skeletal muscles, the craniofacial muscles show marked anatomical, physiological, and biological deviations from typical limb skeletal muscles. The uniqueness of the craniofacial muscle phenotype has led to their being described by some as “paradoxical” members of the skeletal muscle group (Noden and Francis-West 2006).
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References
Amin M, Harris D, Cassel S, Grimes E, Heiman-Patterson T (2006) Sensory testing in the assessment of laryngeal sensation in patients with amyotrophic lateral sclerosis. Ann Otol Rhinol Laryngol 115(7):528–534
Andrade FH, Porter JD, Kaminski HJ (2000) Eye muscle sparing by the muscular dystrophies: lessons to be learned? Microsc Res Tech 48(3–4):192–203
Andrade FH, Merriam AP, Guo W et al (2003) Paradoxical absence of M lines and down regulation of creatine kinase in mouse extraocular muscle. J Appl Physiol 95(2):692–699
Andrade FH, Hatala DA, McMullen CA (2004) Carbonic anhydrase isoform expression and functional role in rodent extraocular muscle. Pflugers Arch 448(5):547–551
Andrade FH, McMullen CA, Rumbaut RE (2005) Mitochondria are fast Ca2+ sinks in rat extraocular muscles: a novel regulatory influence on contractile function and metabolism. Invest Ophthalmol Vis Sci 46(12):4541–4547
Bendiksen FS, Dahl HA, Teig E (1981) Innervation pattern of different types of muscle fibres in the human thyroarytenoid muscle. Acta Otolaryngol 91(5–6):391–397
Benninger MS, Gillman JB, Altman JS (1998) Changing etiology of vocal fold immobility. Laryngoscope 108:1346–1350
Brandon C, Rosen C, Georgelis G, Horton M, Mooney M, Sciote J (2003a) Muscle fiber type composition and effects of vocal fold immobilization on the two compartments of the human posterior cricoarytenoid: a case study of four patients. J Voice 17(1):63–75
Brandon CA, Rosen C, Georgelis G, Horton MJ, Mooney MP, Sciote JJ (2003b) Staining of human thyroarytenoid muscle with myosin antibodies reveals some unique extrafusal fibers, but no muscle spindles. J Voice 17(2):245–254
Cheng G, Merriam AP, Gong B, Leahy P, Khanna S, Porter JD (2004) Conserved and muscle-group-specific gene expression patterns shape postnatal development of the novel extraocular muscle phenotype. Physiol Genomics 18(2):184–195
Close RI, Luff AR (1974) Dynamic properties of inferior rectus muscle of the rat. J Physiol 236(2):259–270
Davis E (1914) Myasthenia gravis, with affection of the larynx and soft palate. Proc R Soc Med 7(Laryngol Sect):63–65
DePaul R, Brooks BR (1993) Multiple orofacial indices in amyotrophic lateral sclerosis. J Speech Hear Res 36(6):1158–1167
Dursum G, Sataloff R, Spiegel J et al (1996) Superior laryngeal nerve paralysis and paresis. J Voice 10:206–211
Engel AG, Banker BQ (1994) Ultrastructural changes in diseased muscle. In: Engel AG, Franzini-Armstrong C (eds) Myology, vol 1, 2nd edn. McGraw-Hill, New York, pp 889–1017
Feehery JM, Pribitkin EA, Heffelfinger RN et al (2003) The evolving etiology of bilateral vocal fold immobility. J Voice 17(1):76–81
Fischer MD, Budak MT, Bakay M et al (2005) Definition of the unique human extraocular muscle allotype by expression profiling. Physiol Genomics 22(3):283–291
Fry L, Stemple J, Andreatta R, Harrison A, Andrade F (2010) Effect of dystrophin deficiency on selected intrinsic laryngeal muscles of the mdx mouse. J Speech Lang Hear Res 53:633–647
Gambino DR, Malmgren JT, Gacek RR (1985) Three-dimensional computer reconstruction of the neuromuscular junction in human posterior cricoarytenoid muscle. Laryngoscope 95:556–590
Gardner GM, Benninger MS (2006) Vocal fold paralysis. In: Rubin JS, Sataloff RT, Korovin GS (eds) Diagnosis and treatment of voice disorders, 3rd edn. Plural Publishing, San Diego, pp 471–491
Goding GS Jr, Al-Sharif KI, McLoon LK (2005) Myonuclear addition to uninjured laryngeal myofibers in adult rabbits. Ann Otol Rhinol Laryngol 114(7):552–557
Hardiman O, van den Berg LH, Kiernan MC (2011) Clinical diagnosis and management of amyotrophic lateral sclerosis. Nat Rev Neurol 7(11):639–649. doi:10.1038/nrneurol.2011.153
Heman-Ackah YD, Barr A (2006) The value of laryngeal electromyography in the evaluation of laryngeal motion abnormalities. J Voice 20(3):452–460
Higo R, Nito T, Tayama N (2005) Videofluoroscopic assessment of swallowing function in patients with myasthenia gravis. J Neurol Sci 231:45–48
Johns MM, Urbanchek M, Chepeha DB, Kuzon WM Jr, Hogikyan ND (2001) Thyroarytenoid muscle maintains normal contractile force in chronic vocal fold immobility. Laryngoscope 111(12):2152–2156
Kaminski HJ, al-Hakim M, Leigh RJ, Katirji MB, Ruff RL (1992) Extraocular muscles are spared in advanced Duchenne dystrophy. Ann Neurol 32(4):586–588
Kanda T, Yoshihara T, Miyazaki M, Kaneko T (1983) Neuromuscular junctions of the posterior cricoarytenoid muscle in the cat: fluorescent staining and autoradiography of acetylcholine receptors and histochemical staining of cholinesterase. Acta Otolaryngol Suppl 393:25–32
Kano S, Horowitz JB, Sasaki CT (1991) Posterior cricoarytenoid muscle denervation. Arch Otolaryngol Head Neck Surg 117(9):1019–1020
Karpati G, Carpenter S, Prescott S (1988) Small-caliber skeletal muscle fibers do not suffer necrosis in mdx mouse dystrophy. Muscle Nerve 11(8):795–803
Kelchner KN, Stemple JC, Gerdeman B, Le Borgne W, Adam S (1999) Etiology, pathophysiology, treatment choices, and voice results for unilateral adductor vocal fold paralysis: a 3-year retrospective. J Voice 13(4):592–601
Khurana TS, Prendergast RA, Alameddine HS, Tomé FM, Fardeau M, Arahata K, Sugita H, Kunkel LM (1995) Absence of extraocular muscle pathology in Duchenne’s muscular dystrophy: role for calcium homeostasis in extraocular muscle sparing. J Exp Med 182(2):467–475
Kjellgren D, Ryan M, Ohlendieck K, Thornell LE, Pedrosa-Domellof F (2003) Sarco(endo)plasmic reticulum Ca2+ ATPases (SERCA1 and -2) in human extraocular muscles. Invest Ophthalmol Vis Sci 44(12):5057–5062
Kluin K, Bromberg M, Feldman E, Simmons Z (1996) Dysphagia in elderly men with myasthenia gravis. J Neurol Sci 138:49–52
Kobayashi J, Mackinnon SE, Watanabe O, Ball DJ, Gu XM, Hunter DA, Kuzon WM Jr (1997) The effect of duration of muscle denervation on functional recovery in the rat model. Muscle Nerve 20(7):858–866
Konig WF, von Leden H (1961) The peripheral nervous system of the human larynx. Arch Otolaryngol 74:45–55
Langmore SE, Lehman ME (1994) Physiologic deficits in the orofacial system underlying dysarthria in amyotrophic lateral sclerosis. J Speech Hear Res 37(1):28–37
Lansman JB, Franco A Jr (1991) What does dystrophin do in normal muscle? J Muscle Res Cell Motil 12(5):409–411
Lapidos KA, Kakkar R, McNally EM (2004) The dystrophin glycoprotein complex: signaling strength and integrity for the sarcolemma. Circ Res 94(8):1023–1031
Lawson G, Remacle M, Hamoir M, Jamart J (1996) Posterior cordectomy and subtotal arytenoidectomy for the treatment of bilateral vocal fold immobility: functional results. J Voice 10:314–319
Lexell J, Downham D, Sjostrom M (1986) Distribution of different fibre types in human skeletal muscles. Fibre type arrangement in m. vastus lateralis from three groups of healthy men between 15 and 83 years. J Neurol Sci 72(2–3):211–222
Luff AR (1981) Dynamic properties of the inferior rectus, extensor digitorum longus, diaphragm, and soleus muscles of the mouse. J Physiol 313:161–171
Lundy DS, Roy S, Xue JW, Casiano RR, Jassir D (2004) Spastic/spasmodic vs. tremulous vocal quality: motor speech profile analysis. J Voice 18(1):146–152
Lynch GS, Frueh BR, Williams DA (1994) Contractile properties of single skinned fibres from the extraocular muscles, the levator and superior rectus, of the rabbit. J Physiol 475(2):337–346
Mao V, Abaza M, Speigel J et al (2001) Laryngeal myasthenia gravis: report of 40 cases. J Voice 15(1):122–130
Marques MJ, Ferretti R, Vomero VU, Minatel E, Neto HS (2007) Intrinsic laryngeal muscles are spared from myonecrosis in the mdx mouse model of Duchenne muscular dystrophy. Muscle Nerve 35(3):349–353
Mauro A (1961) Satellite cell of skeletal muscle fibers. J Biophys Biochem Cytol 9:493–495
McLoon LK, Rowe J, Wirtschafter J, McCormick KM (2004) Continuous myofiber remodeling in uninjured extraocular myofibers: myonuclear turnover and evidence for apoptosis. Muscle Nerve 29(5):707–715
McLoon LK, Thorstenson KM, Solomon A, Lewis MP (2007) Myogenic precursor cells in craniofacial muscles. Oral Dis 13(2):134–140
Menache CC, Darris BT (2001) Myopathies: inherited myopathies. In: Katirji B, Kaminski HJ, Preston DC, Ruff RL, Shapiro BE (eds) Neuromuscular disorders in clinical practice. Butterworth-Heinemann, Boston, pp 1028–1048
Miyamaru S, Kumai Y, Ito T, Yumoto E (2008) Effects of long-term denervation on the rat thyroarytenoid muscle. Laryngoscope 118(7):1318–1323
Morledge DR, Lauvstad WA, Calcaterra TC (1973) Delayed reinnervation of the paralyzed larynx. An experimental study in the dog. Arch Otolaryngol 97(3):291–293
Muller J, Vayssiere N, Royuela M et al (2001) Comparative evolution of muscular dystrophy in diaphragm, gastrocnemius and masseter muscles from old male mdx mice. J Muscle Res Cell Motil 22(2):133–139
Noden DM, Francis-West P (2006) The differentiation and morphogenesis of craniofacial muscles. Dev Dyn 235(5):1194–1218
Nomoto M, Yoshihara T, Kanda T (1991) Synapse formation by autonomic nerves at the previously denervated neuromuscular junctions of the feline intrinsic laryngeal muscles. Brain Res 539:276–286
Nomoto M, Yoshihara T, Kanda T, Konno A, Kaneko T (1993) Misdirected reinnervation in the feline intrinsic laryngeal muscles after long-term denervation. Acta Otolaryngol Suppl 506:71–74
Nomura K, Kunibe I, Katada A, Wright CT, Huang S, Choksi Y, Mainthia R, Billante C, Harabuchi Y, Zealear DL (2010) Bilateral motion restored to the paralyzed canine larynx with implantable stimulator. Laryngoscope 120(12):2399–2409
Norton M, Verstegeden A, Maxwell LC, McCarter RM (2001) Constancy of masseter muscle structure and function with age in F344 rats. Arch Oral Biol 46(2):139–146
Patel U, Forsen J (2001) Foreign body aspiration: an unusual presentation of myasthenia gravis. Otolaryngol Head Neck Surg 124:698–699
Pavlath GK, Thaloor D, Rando TA, Cheong M, English AW, Zheng B (1998) Heterogeneity among muscle precursor cells in adult skeletal muscles with differing regenerative capacities. Dev Dyn 212(4):495–508
Perie S, St Guily JL, Callard P, Sebille A (1997) Innervation of adult human laryngeal muscle fibers. J Neurol Sci 149(1):81–86
Perie S, Agbulut O, St Guily JL, Butler-Browne GS (2000) Myosin heavy chain expression in human laryngeal muscle fibers. A biochemical study. Ann Otol Rhinol Laryngol 109(2):216–220
Porter JD, Baker RS (1996) Muscles of a different ‘color’: the unusual properties of the extraocular muscles may predispose or protect them in neurogenic and myogenic disease. Neurology 46(1):30–37
Porter JD, Merriam AP, Gong B et al (2003) Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle. J Exp Biol 206(Pt 17):3101–3112
Porter JD, Merriam AP, Leahy P, Gong B, Feuerman J, Cheng G, Khanna S (2004) Temporal gene expression profiling of dystrophin-deficient (mdx) mouse diaphragm identifies conserved and muscle group-specific mechanisms in the pathogenesis of muscular dystrophy. Hum Mol Genet 13(3):257–269
Rhee HS, Lucas CA, Hoh JF (2004) Fiber types in rat laryngeal muscles and their transformations after denervation and reinnervation. J Histochem Cytochem 52(5):581–590
Robinson JL, Mandel S, Sataloff RT (2005) Objective voice measures in nonsinging patients with unilateral superior laryngeal nerve paresis. J Voice 19(4):665–667
Romo LV, Curtin HD (1999) Atrophy of the posterior cricoarytenoid muscle as an indicator of recurrent laryngeal nerve palsy. AJNR Am J Neuroradiol 20(3):467–471
Ropper AH, Samuels MA (2009) Syndrome of muscular weakness and wasting without sensory changes; section of Degenerative diseases of the nervous system. In: Ropper AJ, Samuels MA (eds) Adams and Victor’s principles of neurology, 9th edn. McGraw-Hill, New York, pp 1058–1070
Rossi G, Cortesina G (1965) Multi-motor end-plate muscle fibers in the human vocalis muscle. Nature 206:629–630
Roy N, Barton M, Smith M, Dromey C, Merrill M, Sauder C (2009) An in vivo model of external superior laryngeal nerve paralysis: laryngoscopic findings. Laryngoscope 119(5):1017–1032
Rubin JS, Sataloff RT, Korovin GS (eds) (2003) Diagnosis and treatment of voice disorders, 2nd edn. Thomson Delmar Learning, Clifton Park, NY
Sadeh M, Kronenberg J, Gaton E (1981) Histochemistry of human laryngeal muscles. Cell Mol Biol Incl Cyto Enzymol 27(6):643–648
Sataloff RT, Mandel S, Mann EA, Ludlow CL (2004) Practice parameter: laryngeal electromyography (an evidence-based review). J Voice 18(2):261–274
Sciote JJ, Morris TJ, Brandon CA, Horton MJ, Rosen C (2002) Unloaded shortening velocity and myosin heavy chain variations in human laryngeal muscle fibers. Ann Otol Rhinol Laryngol 111(2):120–127
Shindo ML, Herzon GD, Hanson DG, Cain DJ, Sahgal V (1992) Effects of denervation on laryngeal muscles: a canine model. Laryngoscope 102(6):663–669
Shinners MJ, Goding GS, McLoon LK (2006) Effect of recurrent laryngeal nerve section on the laryngeal muscles of adult rabbits. Otolaryngol Head Neck Surg 134(3):413–418
Shiotani A, Flint PW (1998) Expression of extraocular-superfast-myosin heavy chain in rat laryngeal muscles. Neuroreport 9(16):3639–3642
Shiotani A, Westra WH, Flint PW (1999) Myosin heavy chain composition in human laryngeal muscles. Laryngoscope 109(9):1521–1524
Silbergleit AK, Johnson AF, Jacobson BH (1997) Acoustic analysis of voice in individuals with amyotrophic lateral sclerosis and perceptually normal vocal quality. J Voice 11(2):222–231
Spencer RF, Porter JD (2006) Biological organization of the extraocular muscles. In: Buttner-Ennever JA (ed) Neuroanatomy of the oculomotor system, vol 151. Elsevier, Boston, pp 43–80
Stemple J, Glaze L, Klaben B (2009) Clinical voice pathology: theory and management, 4th edn. Plural Publishing, San Diego
Tellis CM, Rosen C, Thekdi A, Sciote JJ (2004) Anatomy and fiber type composition of human interarytenoid muscle. Ann Otol Rhinol Laryngol 113(2):97–107
Thomas LB, Joseph G, Adkins T, Andrade F, Stemple JC (2008) Laryngeal muscles are spared in the dystrophin-deficient mdx mouse. J Speech Lang Hear Res 51:586–595
Titze IR (1994) Principles of voice production. Prentice-Hall, Englewood Cliffs, NJ
Tomik J, Tomik B, Partyka D, Skladzien J, Szczudlik A (2007) Profile of laryngological abnormalities in patients with amyotrophic lateral sclerosis. J Laryngol Otol 121:1064–1069
van der Graaff M, Grolman W, Westermann E, Boogaardt C, Koelman H, van der Kooi A, Tijssen M, de Visser M (2009) Vocal cord dysfunction in amyotrophic lateral sclerosis: four cases and a review of the literature. Arch Neurol 66(11):1329–1333
Vega-Cordova X, Cosenza NM, Helfert RH, Woodson GE (2010) Neurotrophin expression of laryngeal muscles in response to recurrent laryngeal nerve transection. Laryngoscope 120(8):1591–1596
Watras JM (2004) Skeletal muscle physiology. In: Berne RM, Levy MN, Koeppen BM, Stanton BA (eds) Physiology. Mosby, St. Louis, pp 223–245
Watts CR, Vanryckeghem M (2001) Laryngeal dysfunction in amyotrophic lateral sclerosis: a review and case report. BMC Ear Nose Throat Disord 1(1):1
Wilatt D, Stell P (1991) Vocal cord paralysis. In: Paparella M, Shumrick D (eds) Otolaryngology, 3rd edn. WB Saunders, Philadelphia, PA
Woodson GE, Hughes LF, Helfert R (2008) Quantitative assessment of laryngeal muscle morphology after recurrent laryngeal nerve injury: right vs. left differences. Laryngoscope 118(10):1768–1770
Wu YZ, Baker MJ, Marie JP, Crumley R, Caiozzo VJ (2004) The plasticity of denervated and reinnervated laryngeal muscle: focus on single-fiber myosin heavy-chain isoform expression. Arch Otolaryngol Head Neck Surg 130(9):1070–1082
Xu W, Han D, Hu H, Fan E (2009) Characteristics of experimental recurrent laryngeal nerve surgical injury in dogs. Ann Otol Rhinol Laryngol 118(8):575–580
Yoshihara T, Kanda T, Yaku Y, Kaneko T (1984) Neuromuscular junctions of the posterior cricoarytenoid muscle in the human adult, human fetus and cat: histochemical and electron microscopic study. Acta Otolaryngol 97:161–168
Yoshihara T, Nomoto M, Kanda T, Ishii T (1991) Ultrastructural and histochemical study of the neuromuscular junctions in the denervated intrinsic laryngeal muscle of the cat. Acta Otolaryngol 111:607–614
Yoshihara T, Ishii T, Iwata M, Nomoto M (1998) Ultrastructural and histochemical study of the motor end plates of the intrinsic laryngeal muscles in amyotrophic lateral sclerosis. Ultrastruct Pathol 22:121–1266
Zealear D, Billante C (2004) Neurophysiology of vocal fold paralysis. Otolaryngol Clin North Am 37:1–23
Zealear DL, Kunibe I, Nomura K, Billante C, Singh V, Huang S, Bekeny J, Choksi Y, Harabuchi Y, Katada A (2009) Rehabilitation of bilaterally paralyzed canine larynx with implantable stimulator. Laryngoscope 119(9):1737–1744
Zemlin WR (1988) Speech and hearing science: anatomy and physiology, 3rd edn. Prentice-Hall, Englewood Cliffs, NJ
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Stemple, J.C., Fry, L., Andreatta, R.D. (2012). Laryngeal Muscle Response to Neuromuscular Diseases and Specific Pathologies. In: McLoon, L., Andrade, F. (eds) Craniofacial Muscles. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4466-4_11
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