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Nanoparticles for Targeted and Temporally Controlled Drug Delivery

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Multifunctional Nanoparticles for Drug Delivery Applications

Part of the book series: Nanostructure Science and Technology ((NST))

Abstract

With advances in nanotechnology, it is now possible to develop highly specific and effective treatments for a myriad of important human diseases including cancer and cardiovascular and inflammatory diseases. One important obstacle in the development of safer and more effective therapeutics has been the challenge of delivering drugs to the site of action at an optimal exposure and rate. The design and development of biocompatible, targeted nanoparticles that control the release of drugs at the site of interest has the potential to revolutionize drug development and enable entirely new therapeutic approaches such as RNA interference (RNAi). This chapter gives an insight into the development of nanoparticle platforms for the targeted and temporally controlled delivery of drugs with minimal off target effects and reviews the available classes of ligands for targeting applications.

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Authors and Affiliations

  1. Department of Anesthesiology, Laboratory of Nanomedicine and Biomaterials, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA, 02115, USA

    Archana Swami, Jinjun Shi, Suresh Gadde, Alexander R. Votruba, Nagesh Kolishetti & Omid C. Farokhzad

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  1. Archana Swami
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  5. Nagesh Kolishetti
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  6. Omid C. Farokhzad
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Correspondence to Omid C. Farokhzad .

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Editors and Affiliations

  1. Drug Delivery Solutions LLC, Temple Street 16, Arlington, 02476, Massachusetts, USA

    Sonke Svenson

  2. Princeton University, n/a, Princeton, 08544, USA

    Robert K. Prud'homme

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© 2012 Springer Science+Business Media, LLC

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Swami, A., Shi, J., Gadde, S., Votruba, A.R., Kolishetti, N., Farokhzad, O.C. (2012). Nanoparticles for Targeted and Temporally Controlled Drug Delivery. In: Svenson, S., Prud'homme, R. (eds) Multifunctional Nanoparticles for Drug Delivery Applications. Nanostructure Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2305-8_2

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  • DOI: https://doi.org/10.1007/978-1-4614-2305-8_2

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