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Mouse Mammary Tumor Virus and Cancer

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Cancer Associated Viruses

Part of the book series: Current Cancer Research ((CUCR))

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Abstract

The retrovirus mouse mammary tumor virus (MMTV) was discovered in the 1930s as a milk-transmitted agent that causes breast cancer in mice. MMTV causes mammary tumors by insertional activation or mutation of cellular oncogenes. Some of the oncogenes activated by MMTV insertion have been also associated with human breast cancer. In addition to allowing the identification of oncogenes associated with this disease, the MMTV long terminal repeat has been used to create numerous strains of transgenic mice with genetic predisposition to breast cancer. Thus, this virus has provided one of the most useful models for understanding human breast cancer.

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  1. Department of Microbiology, Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    Susan R. Ross

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  1. Perelman School of Medicine, University of Pennsylvania, Hamilton Walk 3610, Philadelphia, 19104, Pennsylvania, USA

    Erle S. Robertson

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Ross, S.R. (2012). Mouse Mammary Tumor Virus and Cancer. In: Robertson, E. (eds) Cancer Associated Viruses. Current Cancer Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0016-5_29

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