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Pharmacological Advances in Cerebrovascular Protection

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Current Techniques in Neurosurgery

Abstract

Recent research in the area of ischemic brain injury has provided a better basic understanding of the events leading to cell death. This work has also permitted the development of a variety of strategies that may prevent or reverse brain ischemia. Such strategies may have applications in preventing cerebral ischemic injury in high-risk neurosurgical or cardiovascular patients as well as treatment of stroke patients. This chapter reviews the pathophysiology of ischemic brain injury as well as current and future neuroprotectants as they relate to potential clinical use. Classes of compounds reviewed include barbiturates, calcium antagonists, glutamate antagonists, 21-aminosteroids, citicholine, lubeluzole, and mild hypothermia.

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Authors
  1. Midori A Yenari
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  2. Gary K Steinberg
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Editors and Affiliations

  1. School of Medicine, The George Washington University, Washington, DC, USA

    Michael Salcman MD, FACS (Clinical Professor of Neurosurgery, Chief of the Division of Neurosurgery) (Clinical Professor of Neurosurgery, Chief of the Division of Neurosurgery)

  2. Sinai Hospital, Baltimore, Maryland, USA

    Michael Salcman MD, FACS (Clinical Professor of Neurosurgery, Chief of the Division of Neurosurgery) (Clinical Professor of Neurosurgery, Chief of the Division of Neurosurgery)

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© 1998 Current Medicine, Inc.

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Yenari, M.A., Steinberg, G.K. (1998). Pharmacological Advances in Cerebrovascular Protection. In: Salcman, M. (eds) Current Techniques in Neurosurgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9350-4_10

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