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Replication of Drosophila Mitochondrial DNA

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Replication of Viral and Cellular Genomes

Part of the book series: Developments in Molecular Virology ((DMVI,volume 2))

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Abstract

Mitochondrial DNA (mtDNA) molecules of Drosophila include a region of exceptionally high adenine + thymine (A+T) content which, though homologously located, varies in size from 1.0 kb to 5.1 kb in different species. In all species examined, replication begins at a unique site within the A+T-rich region and proceeds in the same direction towards the molecule’s ribosomal RNA genes. Most molecules are replicated by a highly asymmetrical mode in which synthesis of one strand can be up to 100% complete before synthesis of the second strand is initiated. In a minority of molecules, a more symmetrical mode of synthesis is employed. Evidence has been obtained that within A+T-rich regions extensive sequence divergences have taken place both between species and within species. The A+T-rich region shares many features with the replication origin-containing region of vertebrate mtDNA molecules, supporting the view that the two regions are derived from a common ancestral sequence.

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Authors
  1. David R. Wolstenholme
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  2. Judy M. Goddard
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  3. Christiane M.-R. Fauron
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Editor information

Editors and Affiliations

  1. The Hebrew University of Jerusalem, Israel

    Yechiel Becker

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© 1983 Martinus Nijhoff Publishing, Boston

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Wolstenholme, D.R., Goddard, J.M., Fauron, C.MR. (1983). Replication of Drosophila Mitochondrial DNA. In: Becker, Y., Hadar, J. (eds) Replication of Viral and Cellular Genomes. Developments in Molecular Virology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3888-8_7

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  • DOI: https://doi.org/10.1007/978-1-4613-3888-8_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3890-1

  • Online ISBN: 978-1-4613-3888-8

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