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Axonal Transport of Complex Carbohydrates

  • Chapter
Complex Carbohydrates of Nervous Tissue

Abstract

The classic study of Weiss and Hiscoe (1948) provided an early indication that bulk translocation of intracellular material occurs along axons. They observed that a constricting cuff placed on a nerve caused accumulation of axoplasm proximal to the constriction. When the cuff was removed, the bolus of axoplasm migrated distally along the nerve at a rate of 1–2 mm/day. In the following years, the technique of nerve constriction was used to document the intraaxonal migration of a variety of enzymes and subcellular organelles (reviewed by Grafstein, 1969). Considerable impetus was provided to axonal-transport work by the discovery that various isotopically labeled substances could be used to trace the movement of axonal constituents (Ochs and Burger, 1958; Weiss, 1961; Miani, 1962; Droz and Leblond, 1963; Taylor and Weiss, 1965). These studies led to a general acceptance of the use of radioisotopes to label axonally transported molecules, producing a flood of publications from the mid-1960’s up to the present.

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Authors and Affiliations

  1. Department of Biological Science, Florida State University, Tallahassee, Florida, USA

    J. S. Elam

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  1. J. S. Elam
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  1. New York University Medical Center, New York, New York, USA

    Richard U. Margolis

  2. Downstate Medical Center, State University of New York, Brooklyn, New York, USA

    Renée K. Margolis

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© 1979 Plenum Press, New York

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Elam, J.S. (1979). Axonal Transport of Complex Carbohydrates. In: Margolis, R.U., Margolis, R.K. (eds) Complex Carbohydrates of Nervous Tissue. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2925-1_12

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  • DOI: https://doi.org/10.1007/978-1-4613-2925-1_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-2927-5

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