Summary
Oxygen radical production by neutrophils stimulated the oxidation of adrenaline through the adrenochrome pathway. The two major catabolites on this pathway were adrenochrome and adrenolutin. A compound with the same retention time as adrenochrome on hplc was detected in a biological fluid rich in neutrophils. Oxidase activity was found in serum from patients following myocardial infarction which may be of importance in assessing the clinical and pathogenic significance of oxygen radicals in heart disease.
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© 1985 Martinus Nijhoff Publishing, Boston
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Matthews, S.B., Campbell, A.K. (1985). The Adrenochrome Pathway: Its Potential Significance in Stress Induced Heart Disease. In: Beamish, R.E., Panagia, V., Dhalla, N.S. (eds) Pathogenesis of Stress-Induced Heart Disease. Developments in Cardiovascular Medicine, vol 46. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2589-5_24
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DOI: https://doi.org/10.1007/978-1-4613-2589-5_24
Publisher Name: Springer, Boston, MA
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