Skip to main content
SpringerLink
Log in

The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3

  • Chapter
Microenvironments in the Lymphoid System

Abstract

The precursors of macrophages, originating in the bone marrow, differentiate into circulating monocytes, which, after leaving the peripheral blood for the tissue compartments, differentiate into macrophages. The macrophages form a heterogeneous population, as expressed by differences in their characteristics, like morphology, density, enzyme activity, cell surface properties and functional capacities. Together these characteristics determine the phenotypical appearance of macrophages, which differs with different environmental circumstances, like the state of activity3,6,20,32, the developmental stage of the individual macrophage7, the localization in different tissues12,14,26 and compartments15 and often a combination of these factors. Whether these environmental conditions determine the phenotypical appearance of the macrophages24 or the origin of the heterogeneity is already determined at bone marrow level5 is still a subject of discussion.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. A.N. Barclay. Immunology 42: 593 (1981).

    PubMed  CAS  Google Scholar 

  2. A.N. Barclay. Immunology 44: 727 (1981).

    PubMed  CAS  Google Scholar 

  3. R.H.J. Beelen, D.M. Broekhuis-Fluitsma, and E.C.M. Hoefsmit. Ultramicroscopy 3: 129 (1978).

    Google Scholar 

  4. D.I. Beller, and E.R. Unanue. J. Immunol. 121: 1861 (1978).

    PubMed  CAS  Google Scholar 

  5. I. Bursuker, and R. Goldman. J. Reticuloendothel. Soc. 33: 207 (1983).

    PubMed  CAS  Google Scholar 

  6. Z.A. Cohn. J. Immunol. 121: 813 (1978).

    PubMed  CAS  Google Scholar 

  7. Z.A. Cohn, and B. Benson. J. Exp. Med. 121: 153 (1964).

    Article  Google Scholar 

  8. A.M. Duijvestijn, T. Sminia, Y.G. Kohler, E.M. Janse, and E.C.M. Hoefsmit. In: In vivo immunology (Nieuwenhuis, P., Van den Broek, A.A. and Hanna, M.G. Jr. eds.), Plenum Press, New York, p. 441 (1982).

    Google Scholar 

  9. C.D. Dijkstra. J. Reticuloendothel. Soc. 32: 167 (1982).

    CAS  Google Scholar 

  10. C.D. Dijkstra, E.A. Dopp, and E.W.A. Kamperdijk. Cell Tissue Res. 236: 203 (1984).

    Article  PubMed  CAS  Google Scholar 

  11. S. Fazekas de, St. Groth, and D. Scheidegger. J. Immunol. Meth. 35: 1 (1980).

    Article  Google Scholar 

  12. T.J. Flotte, T.A. Springer, and G.J. Thorbecke. Am. J. Pathol. 111: 112 (1982).

    Google Scholar 

  13. J. Gerdes, H. Stein, D.Y. Mason, and A. Ziegler. Virch. Arch. B 42: 161 (1983).

    CAS  Google Scholar 

  14. K.A. Haines, T.J. Flotte, T.A. Springer, I. Gigli, and J. Thorbecke. Proc. Natl. Acad. Sci. USA 80: 3448 (1983).

    Article  PubMed  CAS  Google Scholar 

  15. E.C.M. Hoefsmit, E.W.A. Kamperdijk, H.R. Hendriks, R.H.J. Beelen, and B.M. Balfour. In: Lymph node macrophages (Carr, and Daems, eds.), Plenum Publishing Corporation, p. 417 (1980).

    Google Scholar 

  16. G. Hoffman-Fezer, D. Gotze, H. Rodt, and S. Thierfelder. Immunogenetics 6: 367 (1978).

    Article  Google Scholar 

  17. D.A. Hume, A.P. Robinson, G.G. MacPherson, and S. Gordon. J. Exp. Med. 158: 1522 (1983).

    Article  PubMed  CAS  Google Scholar 

  18. J.H. Humphrey, and D. Grennan. Eur. J. Immunol. 11: 221 (1981).

    Article  PubMed  CAS  Google Scholar 

  19. G. Kohler, and C. Milstein. Nature 256: 495 (1975).

    Article  PubMed  CAS  Google Scholar 

  20. P.S. Morahan. J. Reticuloendothel. Soc. 27: 223 (1980).

    CAS  Google Scholar 

  21. G.J.V. Nossal, A. Abbot, J. Mitchell, and Z. Lummus. J. Exp. Med. 127: 277 (1968).

    Article  PubMed  CAS  Google Scholar 

  22. A.G.E. Pearse. Histochemistry. Theoretical and Applied. Vol. 1, 3rd ed. Edinburgh, Churchill Livingstone (1968).

    Google Scholar 

  23. T. Snook. Anat. Rec. 148: 149 (1964).

    Article  PubMed  CAS  Google Scholar 

  24. C. Sorg. Mol. Immunol. 19: 1275 (1982).

    Article  PubMed  CAS  Google Scholar 

  25. J.G. Streefkerk, and M. van der Ploeg. Histochemistry 40: 105 (1974).

    Google Scholar 

  26. J.J. Twomey, A. Laughter, and M.F. Brown. Clin. Exp. Immunol. 52: 449 (1983).

    PubMed  CAS  Google Scholar 

  27. R. van Furth, Z.A. Cohn, J.G. Hirsch, W.G. Spector, and H.L. Langevoort. Bull WHO 46: 845 (1972).

    PubMed  Google Scholar 

  28. A.J.P. Veerman. Cell Tissue Res. 148: 247 (1974).

    Article  PubMed  CAS  Google Scholar 

  29. A.J.P. Veerman. Z. Immun. Forsch. 150: 45 (1975).

    CAS  Google Scholar 

  30. J.E. Veldman. Acad. Thesis, Groningen, The Netherlands (1970).

    Google Scholar 

  31. A. Villena, A. Zapata, J.M. Rivera-Pomar, M.G. Barrutia, and J. Fonfria. Cell Tissue Res. 229: 219 (1983).

    Article  PubMed  CAS  Google Scholar 

  32. W.S. Walker. J. Reticuloendothel. Soc. 20: 57 (1976).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Histology, Free University, Amsterdam, The Netherlands

    C. D. Dijkstra, E. A. Döpp & G. Kraal

  2. Department of Internal Medicine I, Erasmus University, Rotterdam, The Netherlands

    P. Joling

Authors
  1. C. D. Dijkstra
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. A. Döpp
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Joling
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Kraal
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Nationanl Institute for Medical Research, London, England

    G. G. B. Klaus

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Press, New York

About this chapter

Cite this chapter

Dijkstra, C.D., Döpp, E.A., Joling, P., Kraal, G. (1985). The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3. In: Klaus, G.G.B. (eds) Microenvironments in the Lymphoid System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2463-8_50

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2463-8_50

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9495-5

  • Online ISBN: 978-1-4613-2463-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation