Skip to main content
SpringerLink
Log in
Book cover

Principles of Medical Therapy in Pregnancy pp 990–994Cite as

Principles of Autoimmunity in Pregnancy

  • Chapter

  • 19 Accesses

Abstract

Disturbance in the immunologic tolerance of self is considered autoimmunity. A large variety of clinical disorders (Table 146–1) have been associated with autoimmunity and are therefore frequently referred to as autoimmune diseases. Antibodies against self, so-called autoantibodies, can, however, also occur in totally normal subjects. Furthermore, it is known that these autoantibodies increase with advancing age. It therefore has been suggested that the aging process may at least in part represent a deterioration of the tolerance process to self. Autoantibodies are also usually found after tissue damage. This observation also suggests that the presence of autoimmunity does not necessarily indicate a disease state.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Smolen, JS, Steinberg AD: Systemic lupus erythematosus and pregnancy: Clinical immunological and theoretical aspects, in Gleicher N (ed): Reproductive Immunology. New York, Alan R Liss, 1981, pp. 283–302

    Google Scholar 

  2. Gilliland BC: Introduction to clinical immunology, in Isselbacher KJ, Adams RD, Braunwald E, et al (eds): Harrison’s Principles of Internal Medicine, ed 9. New York, McGraw-Hill, 1980, pp 315–325

    Google Scholar 

  3. Zulman J, Tela N, Hoffman GS, et al: Problems associated with the management of pregnancies in patients with systemic lupus erythematosus. J Rheumatol 7: 37–42, 1980

    PubMed  CAS  Google Scholar 

  4. Kaufman RL, Kitridov RC: Risk of pregnancy in mixed connective tissue disease. Arthritis Rheum 22: 627 - 632, 1979

    Google Scholar 

  5. Reed NR, Smith MT: Periarteritis nodosa in pregnancy: Report of a case and review of the literature. Obstet Gynecol 55: 381–384, 1980

    PubMed  CAS  Google Scholar 

  6. Katz A: Another case of polymositis in pregnancy. Arch Intern Med 140: 1123, 1980

    Article  PubMed  CAS  Google Scholar 

  7. Glennhurt, W, Cooke CL, Jordan WP, et al: Behcet’s syndrome associated with pregnancy. Obstet Gynecol 53(Suppl): 31s–33s, 1979

    Google Scholar 

  8. Sacks DA, Platt LD, Johnson CS: Autoimmune hemolytic disease during pregnancy. Am J Obstet Gynecol 140: 942–946, 1981

    PubMed  CAS  Google Scholar 

  9. Carloss HW, McMillan R, Crosby WH: Management of pregnancy in women with immune thrombocytopenic purpura. JAMA 244: 2756–2758, 1980

    Article  PubMed  CAS  Google Scholar 

  10. Frank Andersen H, Lynch JP, Johnson TRB Jr: Adult respiratory distress syndrome in obstetrics and gynecology. Obstet Gynecol 55: 291–294, 1980

    Google Scholar 

  11. Silverman RI, Ribner HS: Peripartal cardiomyopathy, in Elkayam U, Gleicher, N (eds): Cardiac Problems in Pregnancy. New York, Alan R Liss, 1982, pp 93–104

    Google Scholar 

  12. Plauche WC: Myasthenia gravis in pregnancy: An update. Am J Obstet Gynecol 135: 691–697, 1979

    PubMed  CAS  Google Scholar 

  13. Fein HG, Godman JM, Weintraub BD: Postpartum lymphocytic thyroiditis in American women: A spectrum of thyroid dysfunction. Am J Obstet Gynecol 138: 504–510, 1980

    PubMed  CAS  Google Scholar 

  14. Marino CT, Pertschuk LP: Pulmonary hemorrhage in systematic lupus erythematosus. Arch Intern Med 141: 201–203, 1981

    Article  PubMed  CAS  Google Scholar 

  15. Weinstein L: Syndrome of hemolysis, elevated liver enzymes, and low platelet count: A severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 142: 159–165, 1982

    PubMed  CAS  Google Scholar 

  16. Sacks DA, Platt LD, Johnson CS: Autoimmune hemolytic disease during pregnancy. Am J Obstet Gynecol 140: 942–946, 1981

    PubMed  CAS  Google Scholar 

  17. Scott JS, Maddison PT, Taylor PV, et al: Connective tissue antibodies to microneucleoprotein and congenital heart block. N Engl J Med 309: 209–212, 1983

    Article  PubMed  CAS  Google Scholar 

  18. Spiera H: The clinical picture of connective tissue diseases in pregnancy, in Gleicher N (ed): Reproductive Immunology, New York, Alan R Liss, 1981, pp 303–307

    Google Scholar 

  19. Scott TR, Cruikshank DP, Kochenour NK, et al: Fetal platelet counts in obstetric management of immunologic throm-bocytopenia purpura. Am J Obstet Gynecol 136: 495–499, 1980

    PubMed  CAS  Google Scholar 

  20. Editorial: Systematic lupus in the newborn. Lancet 1: 859, 1979

    Google Scholar 

  21. Scott JS: Autoimmune disease in infants. Lancet 2: 528, 1979

    Article  PubMed  CAS  Google Scholar 

  22. Feniche GM: Clinical syndromes of myasthenics in infancy and childhood. Pediatrics 45: 488–504, 1970

    Google Scholar 

  23. Green WL: Hormonal and genetic factors in thyrotoxic Graves’ disease and neonatal thyrotoxicosis. JAMA 235: 1449–1450, 1976

    Article  PubMed  CAS  Google Scholar 

  24. Abramowsky CR, Vegas ME, Swinehart G, et al: Decidual vasculopathy of the placenta in lupus erythematosus. N Engl J Med 303: 668–672, 1980

    Article  PubMed  CAS  Google Scholar 

  25. Gleicher N, Adesberg BR, Liu TL, et al: Immune complexes in pregnancy. III. Immune complexes in immune complex-associated conditions. Am J Obstet Gynecol 142: 1011–1015, 1982.

    PubMed  CAS  Google Scholar 

  26. Meurman 0, Terho P, Salmi A: Activation of rheumatoid factor during pregnancy. Lancet 1: 704, 1978

    Google Scholar 

  27. Lubbe WF, Palmer SJ, Butler WS, et al: Fetal survival after predisone suppression of maternal lupus-anticoagulant. Lancet 1: 1361–1363, 1983

    Article  PubMed  CAS  Google Scholar 

  28. Weinstein L: Discussion of the HELLP syndrome-a unique variant of preeclampsialeclampsia. Fifty-first Annual Meeting of the Central Association of Obstetricians and Gynecologists, Colorado Springs, Colorado, October 14, 1983

    Google Scholar 

  29. Pritchard JA, Weisman R, Ratnoff OD, et al: Intravascular hemolysis thrombocytopenia and other hematologic abnor¬malities associated with severe toxemia of pregnancy. N Engl J Med 250: 89–93, 1954

    Article  PubMed  CAS  Google Scholar 

  30. Gleicher N: Discussion of the HELLP syndrome-a unique variant of preeclampsialeclampsia by Louise Weinstein,M.D. Fifty-first Annual Meeting of the Central Association of Obstetricians and Gynecologists, Colorado Springs, Colorado, October 14, 1983

    Google Scholar 

  31. Gleicher N, Siegel I: The immunologic concept of EPH-ges-tosis, in Gleicher N (ed): Reproductive Immunology. New York, Alan R Liss, 1981, pp 219–228

    Google Scholar 

  32. Segonds A, Louradour N, Suc JM, et al: Postpartum hemolytic anemia syndrome: A study of three cases with review of the literature. Clin Nephrol 12: 229–242, 1979

    PubMed  CAS  Google Scholar 

  33. Perkins RP: Thrombocytopenia in obstetric syndromes. A review. Obstet Gynecol Surv 34: 101–114, 1979

    Article  PubMed  CAS  Google Scholar 

  34. Messner HA, Fauser AA, Curtin JE, et al: Control of antibody-mediated pure red cell aplasia by plasmapheresis. N Engl J Med 204: 1334–1338, 1981

    Article  Google Scholar 

  35. Rossi EC, delGreco F, Kwaan HC, et al: Hemodialysis-exchange transfusion for treatment of thrombolic thrombocytopenic purpura. JAMA 244: 1446–1468, 1980

    Article  Google Scholar 

Download references

Authors
  1. Norbert Gleicher
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Rush Medical College, Chicago, Illinois, USA

    Norbert Gleicher M.D. (Professor of Obstetrics and Gynecology and Assistant Professor of Immunology/Microbiology, Chairman) (Professor of Obstetrics and Gynecology and Assistant Professor of Immunology/Microbiology, Chairman)

  2. Department of Obstetrics and Gynecology, Mount Sinai Hospital Medical Center, Chicago, Illinois, USA

    Norbert Gleicher M.D. (Professor of Obstetrics and Gynecology and Assistant Professor of Immunology/Microbiology, Chairman) (Professor of Obstetrics and Gynecology and Assistant Professor of Immunology/Microbiology, Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Publishing Corporation

About this chapter

Cite this chapter

Gleicher, N. (1985). Principles of Autoimmunity in Pregnancy. In: Gleicher, N. (eds) Principles of Medical Therapy in Pregnancy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2415-7_146

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2415-7_146

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9471-9

  • Online ISBN: 978-1-4613-2415-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation