Abstract
In radiotherapy, the dose distribution achieved over the tumor volume, whatever its shape and location, and avoiding damage to surrounding tissues are vital components in the success or failure of the treatment. Moreover, by minimizing the volume irradiated, it becomes possible to deliver higher doses, and as first demonstrated by Ralston Paterson in Manchester, the higher doses tolerated lead to higher cure rates. However, adopting smaller volumes and higher dose levels call for higher precision in delivery, since Shukovsky,(1) Stewart and Jackson,(2) and Herring(3) have shown that there is a steep function relating dose with probability of cure and also risk of damage.
“My object all sublime I shall achieve in time, to let the punishment fit the crime, the punishment fit the crime” (“The Mikado” Gilbert and Sullivan, 1885)
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Jennings, W.A. (1985). The Tracking Cobalt Project. In: Orton, C.G. (eds) Progress in Medical Radiation Physics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2387-7_1
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