Abstract
The subject of cell death has always had a following amongst developmental biologists (Glucksmann, 1951). It is not difficult to see why, for the programmed deletion of cells in specific sites is a prominent and apparently necessary feature of development of most structures, and abnormalities in the pattern and quantity of cell death lead to malformations. Early studies included impressive descriptions of the unusual morphology of cell death in this context (Bellairs, 1961). It became clear that at least some of the deaths were intrinsically programmed — that is they occurred on schedule even when the cells in question were removed from their natural environment and grafted elsewhere (Saunders, 1966). In a number of cell systems, notably the avian wing bud (Fallon and Saunders, 1968; Hinchliffe and Griffiths, 1984), the palatal shelves during fusion (Pratt and Greene, 1976; Hassell and Pratt, 1977), and the motor neurones supplying skeletal muscle (0’Connor and Wyttenbach 1974; Oppenheim, 1984), information continues to accumulate on the stimuli which initiate the programme of death, or can modify it once it is under way.
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© 1986 Plenum Press, New York
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Wyllie, A.H., Morris, R.G., Arends, M.J., Watt, A.E. (1986). Nuclease Activation in Programmed Cell Death. In: Clayton, R.M., Truman, D.E.S. (eds) Coordinated Regulation of Gene Expression. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2245-0_5
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DOI: https://doi.org/10.1007/978-1-4613-2245-0_5
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