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Krukenberg syndrome as a natural manifestation of tumor cell entrapment

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Peritoneal Carcinomatosis: Principles of Management

Part of the book series: Cancer Treatment and Research ((CTAR,volume 82))

Abstract

Since Krukenberg described an unusual type of ovarian tumor in 1896, no one has adequately explained the pathophysiology of this observation [1]. Schlagenhaufer recognized that these ovarian tumors did not originate within the ovary [2]. Rather, they were a secondary cancer deposit from a primary malignancy somewhere in the gastrointestinal tract. The important question concerns the preferential localization and enhanced growth of these cancer deposits in the ovaries at a distance from the primary tumor [3,4]. The Krukenberg syndrome describes the ovary as a unique favored site for dissemination of gastrointestinal cancers by a mechanism that is presented in this chapter. The basic pathophysiology of the phenomenon is described by the tumor cell entrapment hypothesis. This hypothesis suggests basic mechanisms that govern the distribution of peritoneal carcinomatosis and sarcomatosis (see Chapter 6). If this interpretation of the Krukenberg syndrome is correct, definite implications for the treatment of patients who demonstrate this phenomenon may follow.

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Authors
  1. Paul H. Sugarbaker
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  2. Andrew M. Averbach
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Editors and Affiliations

  1. Washington Cancer Institute, 110 Irving Street, NW, Washington, DC, 20010, USA

    Paul H. Sugarbaker M.D., F.A.C.S.

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© 1996 Kluwer Academic Publishers, Boston

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Sugarbaker, P.H., Averbach, A.M. (1996). Krukenberg syndrome as a natural manifestation of tumor cell entrapment. In: Sugarbaker, P.H. (eds) Peritoneal Carcinomatosis: Principles of Management. Cancer Treatment and Research, vol 82. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1247-5_11

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  • DOI: https://doi.org/10.1007/978-1-4613-1247-5_11

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