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Peritoneal Carcinomatosis: Drugs and Diseases pp 149–168Cite as

Peritoneal carcinomatosis: Natural history and rational therapeutic interventions using intraperitoneal chemotherapy

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 81))

Abstract

Gastrointestinal cancer is a malignancy that begins in the epithelial lining of the gut. This tumor progresses by invading the submucosa, then muscular layers, and finally the serosal surface or mesenteric fat. During the course of this invasion into the bowel wall, three routes of dissemination of gastrointestinal cancer occur [1]. If the primary cancer invades into venules, it may travel via the portal vein to the liver sinusoids. Within the liver those tumor emboli that implant will develop into liver metastases [2]. Similarly, lymphatic channels are invaded and lymph nodes can become involved by the malignant process. This usually occurs as an orderly progression of positive nodes along the nodal chain [3]. Full-thickness invasion of the bowel wall may result in tumor penetration through this structure. This causes seeding of cancer on peritoneal surfaces adjacent to the primary malignancy. The distribution of these tumor implants is proximal to the primary tumor but randomly distributed on the nearby surfaces [4].

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Authors
  1. Paul H. Sugarbaker
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Editors and Affiliations

  1. Washington Cancer Institute, Washington Hospital Center, 110 Irving Street, NW, Washington, D.C., 20010, USA

    Paul H. Sugarbaker M.D., F.A.C.S.

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© 1996 Kluwer Academic Publishers, Boston

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Sugarbaker, P.H. (1996). Peritoneal carcinomatosis: Natural history and rational therapeutic interventions using intraperitoneal chemotherapy. In: Sugarbaker, P.H. (eds) Peritoneal Carcinomatosis: Drugs and Diseases. Cancer Treatment and Research, vol 81. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1245-1_13

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  • DOI: https://doi.org/10.1007/978-1-4613-1245-1_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-3726-3

  • Online ISBN: 978-1-4613-1245-1

  • eBook Packages: Springer Book Archive

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