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The Influenza Viruses pp 153–173Cite as

Structure, Function, and Antigenicity of the Hemagglutinin of Influenza Virus

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Part of the book series: The Viruses ((VIRS))

Abstract

The major surface glycoprotein of influenza virus is hemagglutinin (HA). This chapter reviews the two major functions of HA: (1) its involvement in binding to receptors on cells before their infection, and (2) its role in the fusion of viral and endosomal membranes, necessary for the release of the viral genome into the cell. In addition, HA is the viral antigen that interacts with infectivity-neutralizing antibodies; alterations in the molecule enable the virus to escape immune surveillance and cause epidemics of disease. The nature of these changes in antigenicity is discussed.

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Authors and Affiliations

  1. Division of Virology, National Institute for Medical Research, London, NW7 1AA, England

    S. A. Wharton & J. J. Skehel

  2. Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts, 02138, USA

    W. Weis & D. C. Wiley

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  1. S. A. Wharton
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  2. W. Weis
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  3. J. J. Skehel
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  4. D. C. Wiley
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Editors and Affiliations

  1. Graduate Program in Molecular Biology, Memorial Sloan-Kettering Cancer Center, 10021, New York, New York, USA

    Robert M. Krug

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Wharton, S.A., Weis, W., Skehel, J.J., Wiley, D.C. (1989). Structure, Function, and Antigenicity of the Hemagglutinin of Influenza Virus. In: Krug, R.M. (eds) The Influenza Viruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0811-9_3

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  • DOI: https://doi.org/10.1007/978-1-4613-0811-9_3

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