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Molecular Aspects of Phospholipase A2 Activation

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Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 279))

Abstract

A striking characteristic of soluble phospholipases A2 is their tendency to become activated at a lipid-water interface.1 The activity of these enzymes is much greater with aggregated phospholipid substrates than with monomeric substrates. Furthermore, the activity is heavily influenced by the state of the aggregated lipids. Our interests in phospholipase A2 are focussed on the mechanism of the activation process and the physical basis of the role of lipid structure and/or dynamics in that process.

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Authors and Affiliations

  1. Departments of Biochemistry and Pharmacology, University of Virginia, Charlottesville, VA, USA

    Rodney L. Biltonen, Thomas R. Heimburg, Brian K. Lathrop & John D. Bell

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  1. Rodney L. Biltonen
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  2. Thomas R. Heimburg
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  3. Brian K. Lathrop
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  4. John D. Bell
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Editors and Affiliations

  1. National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

    Anil B. Mukherjee

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© 1990 Plenum Press, New York

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Biltonen, R.L., Heimburg, T.R., Lathrop, B.K., Bell, J.D. (1990). Molecular Aspects of Phospholipase A2 Activation. In: Mukherjee, A.B. (eds) Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors. Advances in Experimental Medicine and Biology, vol 279. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0651-1_6

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  • DOI: https://doi.org/10.1007/978-1-4613-0651-1_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7910-5

  • Online ISBN: 978-1-4613-0651-1

  • eBook Packages: Springer Book Archive

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