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Neuropathological Dynamics of Magnetic, Auditory Steady-State Responses in Alzheimer’s Disease

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Advances in Biomagnetism

Abstract

The steady-state auditory mid-latency response in humans is maximal in amplitude and sinusoidal in form in response to repetitive auditory stimulation between 35 and 45 Hz (Galambos et al., 1981). This has been reported in both, EEG and MEG studies. MEG data reported single dipoles in the temporal lobe of cortex in humans after an auditory 40Hz stimulation (Maekelae and Hari, 1987), which were believed to be a part of a thalamo-cortical loop becoming resonant at 40 Hz (Weinberg et al., 1988). Recently, our EEG/MEG studies suggested two dipoles in thalamo-cortical areas, indicating that more than one generator must be involved in the 40Hz response (Ribary et al., 1989a and 1989b). Moreover, these dipoles seemed to be more rigerously in phase in controls than those observed in psychiatric patients.

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References

  • Damasio, A.R. and Hoesen, G.W. (1986) Neuroanatomical correlates of amnesia in Alzheimers’s disease. In Biological Substrates of Alzheimer’s disease. A.B.Scheibel, A.F.Wechsler and M.A.B.Brazier, eds., NY.Academic Press, pp. 65–71.

    Google Scholar 

  • Galambos, R., Makeig, S. and Talmachoff, P.J. (1981) A 40 Hz auditory potential recorded from the human scalp. Natl. Acad. Sci. USA. 78: 2643–2647.

    Article  CAS  Google Scholar 

  • Maekelae, J.P. and Hari, R. (1987) Evidence for cortical origin of the 40 Hz auditory evoked response in man. Electroencephalogr. Clin. Neurophysiol., 66: 539–546.

    Article  Google Scholar 

  • Marco, L.A. and Randels, P.M. (1984) Neurobiology of cognitive deterioration. In Alzheimer’s disease and related disorders. W.E.Kelly, ed., Springfield: C.C.Thomas, pp. 26–80.

    Google Scholar 

  • Maurer.K., Dierks, T. and Ihl, R. (1988) Topographic mapping of auditory evoked P300 in psychiatric disorders. In Functional Brain Imaging, G.Pfurtscheller and F.H. Lopes da Silva, eds., Hans Huber Publisher, Toronto, Canada, pp. 187–192.

    Google Scholar 

  • Ribary, U., Weinberg, H., Brickett, P., Ancill, R.J., Holliday, S. and Johnson, B. (1987) Imaging of EEG and MEG for the estimate of sources in the human brain responsive to antidepressant drugs. Soc. Neurosci. Abstr. 13,1268.

    Google Scholar 

  • Ribary, U., Weinberg, H., Cheyne, D., Johnson, B., Holliday, S. and Ancill, R. (1989a) EEG and MEG (magnetoencephalography) mapping for indexing pathological changes in human brain. European J. Neurosci. Suppl., in press.

    Google Scholar 

  • Ribary, U., Weinberg, H., Johnson, B., Ancill, R. and Holliday, S. (1989b) EEG and MEG mapping of the 40Hz auditory evoked response in depressed patients. Submitted.

    Google Scholar 

  • Scheibel, A.B., Wechsler, A.F. and Brazier, M.A.B. (1986) Biological Substrates of Alzheimer’s disease. NY.Academic Press. 1986.

    Google Scholar 

  • Weinberg, H., Cheyne, D., Brickett, P., Gordon, R. and Harrop, R. (1988) An interaction of cortical sources associated with simultaneous auditory and somesthetic stimulation. In Functional Brain Imaging. G.Pfurtscheller and F.H. Lopes da Silva, eds., Hans Huber Publisher, Toronto, Canada, pp. 83–88.

    Google Scholar 

  • Yamamoto, T., Williamson, S., Kaufman, L., Nicholson, C. and Llinas, R. (1988) Magnetic localization of neuronal activity in the human brain. Proc. Natl. Acad. Sci., 85, 8732–8736.

    Article  PubMed  CAS  Google Scholar 

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© 1989 Plenum Press, New York

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Ribary, U., Llinas, R., Kluger, A., Suk, J., Ferris, S.H. (1989). Neuropathological Dynamics of Magnetic, Auditory Steady-State Responses in Alzheimer’s Disease. In: Williamson, S.J., Hoke, M., Stroink, G., Kotani, M. (eds) Advances in Biomagnetism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0581-1_64

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  • DOI: https://doi.org/10.1007/978-1-4613-0581-1_64

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7876-4

  • Online ISBN: 978-1-4613-0581-1

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