Abstract
Superoxide (O2 −) is an important component of a variety of vascular inflammatory disorders including reperfusion injuries, hemorrhagic shock, oxygen toxicities, infections, neoplasia and apoptosis. Extracellular superoxide dismutase (EC-SOD) has been found in the extracellular spaces and fluids where it is thought to defend against O2 − produced by inflammatory cells. Nitric oxide (NO) is also produced during inflammatory reactions and has some anti-inflammatory properties. In the extracellular spaces the primary species that will react with NO is O2 −. The product of this reaction is peroxynitrite which is a strong proinflammatory mediator. Therefore, to control inflammation, the reaction of O2 − with NO must be prevented. High EC-SOD levels in the extracellular spaces may act to preserve NO and thus create strong anti-inflammatory microenvironments.
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© 1996 Plenum Press, New York
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Day, B., Oury, T., Crapo, J.D. (1996). Interactions of Superoxide Dismutases with Nitric Oxide. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 281. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0355-8_3
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DOI: https://doi.org/10.1007/978-1-4613-0355-8_3
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