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Regulation of the Carbon Dioxide of Arterial Blood by Ventilation

  • Conference paper
Carbon Dioxide and Metabolic Regulations

Part of the book series: Topics In Environmental Physiology And Medicine ((TEPHY))

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Abstract

The production of CO2 in the normal organism may undergo changes from 1 to 20. Since the unique route of elimination is the expired gas, if the alveolar ventilation did not change, the alveolar pressure of CO2, hence its pressure in arterial blood, would also change in the ratio of 1 to 20.

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Bibliography

(1) \(\text{PA}_{\text{CO}_\text{2} }\)

  • Asmussen, E., and Nielsen, M., “Ventilatory response to CO2 during work at normal and at low oxygen tensions.” Acta Physiol. Scand. 39:27–35 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Barr, P. O., Beckman, M., Bjurstedt, H., Brismar, J., Hesser, C. M., and Matell, G., “Time courses of blood gas changes provoked by light and moderate exercise in man.” Acta Physiol. Scand. 60:1–17 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Bhattacharyva, N. K., Cunningham, D. J. C., Goode, R. C., Howson, M. G., Lloyd, B. B., “Hypoxia, ventilation, PCO2, and exercise.” Respiration Physiology 9:329–47 (1970).

    Article  Google Scholar 

  • Hickam, J. B., Pryor, W. W., Page, E. B., and Atwell, R. J., “Respiratory regulation during exercise in unconditioned subject,” J. Clin. Invest. 30:503–16 (1951).

    Article  PubMed  CAS  Google Scholar 

  • Holmgren, A., and Linderholm, H., “Oxygen and CO2 tensions of arterial blood during heavy and exhaustive exercise.” Acta Physiol. Scand. 44:203–15 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Lilienthal, J. L., Riley, R. L., Proemmel, D. D., and Franke, R. E., “An experimental analysis in man of the oxygen measure pressure gradient from alveolar air to arterial blood during rest and exercise at sea level and altitude.” Am. J. Physiol. 147:199–216 (1946).

    PubMed  Google Scholar 

  • Suskind, M., Bruce, R. A., Mac Dowell, M. E., Yu, P. N. G., and Lovejoy, F. W. Jr., “Normal variations in end tidal air and arterial blood CO2 and oxygen tensions during moderate exercise.” J. Appl. Physiol. 3:282–90 (1950).

    PubMed  CAS  Google Scholar 

(2) pH

  • Arborelius, M., and Liljestrand, “Muskelarbeit und Blutreaktion.”Skand. Arch. Physiol. (1923).

    Google Scholar 

  • Barr, D. P., Himwick, H. E., and Green, R. P., “Studies in the physiology of muscular exercise—changes in acid-base equilibrium following short periods of vigorous muscular exercise.” J. Biol. Chem. 55:495–515 (1923).

    CAS  Google Scholar 

  • Barr, P. O., Beckman, M., Bjurstedt, H., Brismar, J., Hesser, C. M., and Matell, G., “Time courses of blood gas changes provoked by light and moderate exercise in man.” Acta Physiol. Scand. 60:1–17 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Chiesa, A. C., Howell, J. B. L., Massoud, A. A. E., and Stretton, T. B., “Acid-base changes in the arterial blood during exercise.” J. Physiol. (London) 175:72–75 (1964).

    Google Scholar 

  • Goldston, M., and Wollack, A. C., “Oxygen and CO2 tensions of alveolar air and arterial blood in healthy young adults at rest and after exercise.” Am. J. Physiol. 151:276–81 (1947).

    Google Scholar 

  • Hickam, J. B., Pryor, W. W., Page, E. B., and Atwell, R. J., “Respiratory regulation during exercise in unconditioned subject.” J. Clin. Invest. 30:503–16 (1951).

    Article  PubMed  CAS  Google Scholar 

  • Holmgren, A., and Linderholm, H., “Oxygen and CO2 tensions of arterial blood during heavy and exhaustive exercise.” Acta Physiol. Scand. 44:203–15 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Lambersten, C. J., Owen, S. G., Wendel, H., Stroud, M. W., Lurie, A. A., Lochner, W., and Clark, G. F., “Respiratory and cerebral circulatory control during exercise at 0.21 and 2.0 atmospheres inspired Po2.” J. Appl. Physiol. 14:966–82 (1959).

    Google Scholar 

(3) \(\text{PA}_{\text{O}_\text{2} }\)

  • Bartels, H., Beer, R., Koepchen, H. P., Wenner, J., and Witt, I., “Messung der alveolär-arteriellen O2 Druckdiflferenz mit verschiedenen Methoden am Menschen bei Ruhe und Arbeit.” Pflüg. Arch. Physiol. 261:133–51 (1955).

    Article  CAS  Google Scholar 

  • Bhattacharyva, N. K., Cunningham, D. J. C., Goode, R. C., Howson, M. G., and Lloyd, B. B., “Hypoxia, ventilation, PCO2 and exercise.” Respiration Physiol. 9:329–47 (1970).

    Article  Google Scholar 

  • Filley, G. F., Gregoire, F., and Wright, G. W., “Alveolar and arterial oxygen tensions and the significance of the alveolar-arterial oxygen tensions difference in normal men.” J. Clin. Invest. 33:517–29 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Lilienthal, J. L., Riley, R. L., Proemmel, D. D., and Franke, R. E., “An experimental analysis in man of the oxygen measure pressure gradient from alveolar air to arterial blood during rest and exercise at sea level and altitude.” Am. J. Physiol. 147:199–216 (1946).

    PubMed  Google Scholar 

  • Suskind, M., Bruce, R. A., Mac Dowell, M. E., Yu, P. N. G., and Lovejoy, F. W., Jr., “Normal variations in end tidal air and arterial blood CO2 and oxygen tensions during moderate exercise.” J. Appl. Physiol. 3:282–90 (1950).

    PubMed  CAS  Google Scholar 

(4) Body Temperature

  • Cotes, J. E., “The role of body temperature in controlling ventilation during exercise in one normal subject breathing oxygen.” J. Physiol. (London) 129:554–63 (1955).

    CAS  Google Scholar 

  • Cunningham, D. J. C., and O’Riordan, J. L. H., “The effect of a rise in the temperature of the body on the respiratory response to CO2 at rest.” Quart. J. Exper. Physiol. 42:329–45 (1957).

    CAS  Google Scholar 

  • Whipp, B. J., and Wasserman, K., “Effect of body temperature on the ventilatory response to exercise.” Resp. Physiol. 8:354–60 (1970).

    Article  CAS  Google Scholar 

(5) Transients

  • Barr, P. O., Beckman, M., Bjurstedt, H., Brismar, J., Hesser, C. M., and Matell, G., “Time courses of blood gas changes provoked by light and moderate exercise in man.” Acta Physiol. Scand. 60:1–17 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Matell, G., “Time courses of changes in ventilation and arterial gas tensions in man induced by moderate exercise.” Acta Physiol. Scand. 58:Suppl. 206 (1963).

    Google Scholar 

  • Rahn, H., and Otis, A. B., “Continuous analysis of alveolar gas composition during work hypercapnia and anoxia.” J. Appl. Physiol. 1:717–24 (1949).

    PubMed  CAS  Google Scholar 

  • Suskind, M., Bruce, R. A., Mac Dowell, M. E., Yu, P. N. G., and Lovejoy, F. W., Jr., “Normal variations in end tidal air and arterial blood CO2 and oxygen tensions during moderate exercise.” J. Appl. Physiol. 3:282–90 (1950).

    PubMed  CAS  Google Scholar 

(6) Gain (a) Response to square wave function

  • Alexander, J. K., West, R. R., Wood, J. A., and Richards, D. W., “Analysis of the respiratory response to carbon dioxide inhalation in varying clinical states of hypercapnia, anoxia and acid base derangment.” J. Clin. Invest. 34:511–32 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Asmussen, E., and Nielsen, M., “Ventilatory response to CO2 during work at normal and at low oxygen tensions.” Acta Physiol. Scand. 39:27–35 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Bannister, R. G., Cunningham, D. J. C., and Douglas, C. G., “The CO2 stimulus to breathing in severe exercise.” J. Physiol. (London) 125:90–117 (1954).

    CAS  Google Scholar 

  • Beaver, W. L., and Wasserman, K., “Transients in Ventilation at start and end of exercise.” J. Appl. Physiol. 25:390–99 (1968).

    Google Scholar 

  • Craig, F. N., “Pulmonary ventilation during exercise and inhalation of CO2.” J. Appl. Physiol. 7:467–71 (1955).

    PubMed  CAS  Google Scholar 

  • Cunningham, D. J. C., Lloyd, B. B., and Patrick, J. M., “The relation between ventilation and end tidal Pco2 in man during moderate exercise with and without CO2 inhalation.” J. Physiol. 169:104P-106P (1963).

    Google Scholar 

  • Cunningham, D. J. C., Lloyd, B. B., and Patrick, J. M., Shaw, D. G., Lahiri, S., and Lloyd, B. B., “The effect of maintained ammonium chloride acidosis on the relation between pulmonary ventilation and alveolar oxygen and carbon dioxide in man.” Quart. J. Exp. Physiol. 46:323–34 (1961).

    PubMed  CAS  Google Scholar 

  • Fenn, W. O., and Craig, A. B., Jr., “Effect of CO2 on respiration using a new method of administering CO2.” J. Appl. Physiol. 18: 1023–24 (1963).

    PubMed  CAS  Google Scholar 

  • Fuleihan, F. J. D., Nakada, T., Suero, J. T., Merrifield, E. S., Dutton, R. E., Permutt, S., and Riley, R. L., “Transient responses to CO 2 breathing of human subjects awake and asleep.” Appl. Physiol. 18:289–94 (1963).

    CAS  Google Scholar 

  • Haywood, C., and Bloete, M. E., “Respiratory responses of healthy young women to CO2 inhalation.” J. Appl. Physiol. 27:No. 1, 32–35 (1969).

    PubMed  CAS  Google Scholar 

  • Hickam, J. B., Pryor, W. W., Page, E. B., and At well, R. J., “Respiratory regulation during exercise in unconditioned subjects.” J. Clin. Invest. 30:503–16 (1951).

    Article  PubMed  CAS  Google Scholar 

  • Lambertsen, C. J., “Carbon dioxide and respiration in acid base homeostasis.” Anesthesiology 21:642–51 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Lambertsen, C. J., Kough, R. H., Cooper, D. Y., Emmel, G. L., Loeschcke, H. H., and Schmidt, C. F., “Comparison of relationship of respiratory minute volume to Pco2 and pH of arterial and internal jugular blood in normal man during hyperventilation produced by low concentrations of CO2 at 1 atmosphere and by O2 at 3 atmospheres.” J. Appl. Physiol. 5:803–13 (1953).

    CAS  Google Scholar 

  • Lerche, D., Katsaros, B., Lerche, G., and Loeschcke, H. H., “Vergleich der Wirkung verschiedener Acidosen (NH4CL, CaCl2, Acetazolamid) auf die Lungenbelüftung beim Menschen.” Pflüg. Arch. Physiol. 270: 450–60 (1959).

    Article  Google Scholar 

  • Matell, G., “Time courses of changes in ventilation and arterial gas tensions in man induced by moderate exercise.” Acta Physiol. Scand. 58:Suppl. 206 (1963).

    Google Scholar 

  • Milic-Emili, J., and Tyler, J. S., “Relation between work output of respiratory muscles and end tidal CO2 tension.” J. Appl. Physiol. 18:497–504 (1963).

    Google Scholar 

  • Nielsen, M., “Untersuchungen liber die Atemregulation beim Menschen.” Skand. Arch. Physiol. 74:Suppl., 87–208 (1936).

    Google Scholar 

  • Nielsen, M., and Asmussen, E. In The regulation of human respiration. Oxford: Blackwell, 503–13 (1963).

    Google Scholar 

  • Nielsen, M., and Asmussen, E. and Smith, H., “Studies on the regulation of respiration in acute hypoxia.” Acta Physiol. Scand. 24:293–313 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Schaefer, K. E., “Respiratory pattern and respiratory response to CO2.” J. Appl. Physiol. 13:1–14 (1958).

    PubMed  CAS  Google Scholar 

  • Teillac, A., and Lefrancois, R., “Analyse des réactions ventilatoires aux cours des périodes d’adaptation et de récupération de l’exercice musculaire chez l’Homme.” J. Physiol. (Paris) 54:417–18 (1962).

    CAS  Google Scholar 

(b) Response to periodic stimulation

  • Bargeton, D., Barres, G., Gauge, P., and Durand, J., “Rôle de PA Co2 dans la régulation de la ventilation de repos étudié en régime périodique.” Physiol. 53:261–62 (1961).

    CAS  Google Scholar 

  • Bellville, J. W., Fleischli, G., and Defares, J. G., “A new method of studying regulation of respiration. The response to sinusoidally varying CO2 inhalation.” Computers Biomed. Res. 2:329–49 (1969).

    Article  CAS  Google Scholar 

  • Stoll, P. J., “Respiratory system analysis based on sinusoidal variations of CO2 in inspired air.” J. Appl. Physiol. 27:389–99 (1969).

    PubMed  CAS  Google Scholar 

  • Thompson, J. P., “Analysis of respiratory control using sinusoidally varying inspired carbon dioxide.” Master’s thesis. Seattle, Washington: University of Washington (1962).

    Google Scholar 

  • Wigertz, O., “Dynamics of ventilation and heart rate in response to sinusoidal work load in man.” J. Appl. Physiol. 29:208–218 (1970).

    PubMed  CAS  Google Scholar 

(7) Chemoreceptors (a) Peripheral

  • Black, A. M. S., Mac Closkey, D. I., Torrance, R. W., “The responses of carotid body chemoreceptors in the cat to sudden changes of hypercapnic and by hypoxic stimuli.” Resp. Physiol. 13:36–49 (1971).

    Article  CAS  Google Scholar 

  • Black, A. M. S., Mac Closkey, D. I., and Torrance, R. W., Arterial che moreceptors. R. W. Torrance, ed. Oxford: Blackwell (1968).

    Google Scholar 

  • Biscoe, M., “Effects of inhalation anaesthetics on carotid body chemoreceptor activity.” Brit. J. Anaesth. 40:2–12 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Dutton, P. E., Fitzgerald, R. S., and Cross, N., “Ventilatory response to square-wave forcing of CO2 at the carotid bodies.” Resp. Physiol. 4:101–108 (1968).

    Article  CAS  Google Scholar 

  • Gray, B. A., “Response of the perfused carotid body to changes in pH and Pco2.” Resp. Physiol. 4:229–45 (1968).

    Article  CAS  Google Scholar 

  • Guz, A., Noble, M., Widdicombe, J. G., Trenchard, D., and Mushin, W. W., “The effect of bilateral block of vagus and glosso pharynged on the ventilatory response to CO2 of a consciens man.” Resp. Physiol. 1:206–10, 38–40 (1966).

    Article  CAS  Google Scholar 

  • Kao, F. F., Michel, C. C., and Mei, S. S., “Carbon dioxide and pulmonary ventilation in muscular exercise.” J. Appl. Physiol. 19:1075–80 (1964).

    PubMed  CAS  Google Scholar 

  • Katsaros, B., “Die Rolle der Chemoreceptoren des Carotisgebiets der narkotisieten Katze für die Antwort der Atmung auf isolierte Änderung der Wasserstoffionen Koncentration und der CO2-Drucks des Blutes.” Pflüg. Arch. Physiol. 282:157–78 (1964).

    Article  Google Scholar 

  • Mitchell, R. A., Carman, C. T., Severinghaus, J. W., Richardson, B. W., Singer, M. M., and Shnider, S. J., “Stability of cerebrospinal fluid pH in chronic acid base disturbances in blood.” J. Appl. Physiol. 20:443–52 (1965).

    PubMed  CAS  Google Scholar 

  • Natsui, T., “Respiratory response to arterial H + at different levels of arterial Pco2 during hyperoxia or hypoxia.” Pflüg. Arch. 316: 34–50 (1970).

    Article  CAS  Google Scholar 

  • Tenney, S. M., and Brooks, J. G., “Carotid bodies, stimulus interaction and ventilatory control in unaesthetized goats.” Resp. Physiol. 1:211–23 (1966).

    Article  CAS  Google Scholar 

(b) Central

  • Fencl, V., Miller, T. B., and Pappenheimer, J. R., “Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid.” Am. J. Physiol. 210:459–72 (1966).

    PubMed  CAS  Google Scholar 

  • Fitzgerald, R. S., Gross, N., and Dutton, R. E., “Ventilatory responses to transient acidic and hypercapnic vertebral artery infusions.” Resp. Physiol. 4:387–95 (1968).

    Article  CAS  Google Scholar 

  • Lambertsen, C. J., “Carbon dioxide and respiration in acid base homeostasis.” Anesthesiology 21:642–51 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Lambertsen, C. J., Semple, S. J. G., Smyth, M. G., and Gelfand, R., “H+ and Pco2 as chemical factors in respiratory and cerebral circulatory control.” J. Appl. Physiol. 16:473–84 (1961).

    PubMed  CAS  Google Scholar 

  • Lensen, J. R., “Influence du pH du liquide céphalo-rachidien sur la respiration.” Experientia (Basel) 6:272 (1950).

    Article  Google Scholar 

  • Loeschcke, H. H., On specificity of CO2 as a respiratory stimulus. Bull. Physiol. Path. Resp. 5:13–25 (1969).

    CAS  Google Scholar 

  • Loeschcke, H. H., Katsaros, B., and Lerche, D., “Differenzierung der Wirkungen von CO2-Druck und Wasserstoffinen-konzentration im Blut auf die Atmung beim Menschen.” Pflüg. Arch. Physiol. 270:461–66 (1960).

    Article  CAS  Google Scholar 

  • Loeschcke, H. H., Koepchen, H. P., and Gertz, K. H., “Uber den Eingluss von Wasserstoffinenkon-zentration und CO 2-Druck im Liquor cerebrospinalis auf die Atmung.” Pflüg. Arch. Physiol 266:569–85 (1958).

    Article  CAS  Google Scholar 

  • Loeschcke, H. H., De Lattre, J., and Schläfke, M., “Reizversuche an der ventralen Oberfläche der Medulla oblongata der Katze mit Beobachtung von Atmung und Blutdruck.” Pflüg. Arch. Physiol 297:R42 (1967).

    Google Scholar 

  • Michel, C. C., “CSF (HCO3) during respiratory acid base disturbance.” J. Physiol (London) 170:66P-67P (1964).

    Google Scholar 

  • Mitchell, R. A., Loeschcke, H. H., Massion, W. H., and Severinghaus, J. W., “Respiratory responses mediated through superficial chemosensitive areas on the medulla.” J. Appl Physiol 18:523–33 (1963).

    CAS  Google Scholar 

  • Natsui, T., “Respiratory response to arterial H + at different levels of arterial pCO2 during hyperoxia or hypoxia.” Pflüg. Arch. 316: 34–50 (1970).

    Article  CAS  Google Scholar 

  • Pappenheimer, J. R., Fencl, V., Heisey, S. R., and Held, D., “Role of cerebral fluids in control of respiration as studied in un-anesthetized goats.” Am. J. Physiol 208: 436–50 (1965).

    PubMed  CAS  Google Scholar 

  • Severinghaus, J. W., Mitchell, R. A., Richardson, B. W., and Singer, M. M., “Respiratory control at high altitude suggesting active transport regulation of CSF pH.” J. Appl Physiol 18:1155–66 (1963).

    PubMed  CAS  Google Scholar 

  • Winterstein, H., and Gökhan, N., “Ammoniumchlorid Acidose und Reaktionstheorie der Atmungsregulation” Arch. Internat. Pharmacodyn. 93:212–32 (1953).

    CAS  Google Scholar 

(8) Theories (a) Chemical drive

  • Douglas, C. G., and Haidane, J. S., “Die Regulation der Atmung beim Menschen.” Ergebn. Physiol. 14:338–430 (1914).

    CAS  Google Scholar 

  • Haidane, J. S., and Priestly, J. G., “The regulation of the lung ventilation.” J. Physiol. (London) 32:225–66 (1905).

    Google Scholar 

  • Winterstein, H., “Die Regulierung der Atmung durch das Blut.” Pflüg. Arch. Physiol. 138: 167–84 (1911).

    Article  CAS  Google Scholar 

(b) Multiple factors theory

  • Comroe, J. H., “The hyperpnea of muscular exercise.” Physiol. Rev. 24:319–39 (1944).

    CAS  Google Scholar 

  • Cunningham, D. J. C., “Some quantitative aspects of the regulation of human respiration in exercise.” Brit. Medi. Bull. 19:25–30 (1963).

    CAS  Google Scholar 

  • Gray, J. S., Pulmonary ventilation and its physiological regulation. Springfield, I11.: Charles C. Thomas (1950).

    Google Scholar 

  • Grodins, F. S., “Analysis of factors concerned in regulation of breathing in exercise.” Physiol, rev. 30:220–39 (1950).

    CAS  Google Scholar 

  • Lambertsen, C. J., “Respiration,” in P. Bard, Medical physiology, 11th ed. St Louis: Mosby (1961).

    Google Scholar 

  • Winterstein, H., “Die Regulierung der Atmung durch das Blut.” Pflüg. Arch. Physiol. 138:167–84 (1911).

    Article  CAS  Google Scholar 

(C) Neurohumoral theory

  • Asmussen, E., Mielsen, M., and Wieth-Pedersen, G., “Cortical or reflex control of respiration during muscular work.” Acta Physiol. Scand. 6:168–75 (1943).

    Article  Google Scholar 

  • Beaver, W. L., and Wasserman, K., “Transients in ventilation at start and end of exercise.” J. Appl. Physiol. 25:390–99 (1968).

    Google Scholar 

  • Craig, F. N., Cummings, E. G., and Blevins, W. V., “Regulation of breathing at beginning of exercise.” Appl. Physiol. 18:1183–87 (1963).

    CAS  Google Scholar 

  • Cunningham, D. J. C., and Gee, J. B. L., “The effect of carbon dioxide on the respiratory reponse to want oxygen in man.” Quart. J. Exp. Physiol. 42:303 (1957).

    PubMed  Google Scholar 

  • Dejours, P., “La régulation de la ventilation au cours de l’exercice musculaire chez l’Homme.” J. Physiol. 51:163–261 (1959).

    CAS  Google Scholar 

  • Dejours, P., “The regulation of breathing during muscular exercise in man. A neurohumoral theory.” In The regulation of human respiration, D. J. C. Cunningham and Lloyd. eds. Oxford: Blackwell Scientific Publications (1963).

    Google Scholar 

  • Dejours, P., “Control of respiration in muscular exercise.” In W. O. Fenn and H. Rahn. Handbook of physiology, section 3, vol. 1. Washington D.C.: American Physiological Society (1964).

    Google Scholar 

  • Dejours, P., Betchel-Labrousse, Y., and Raynaud, J., “Etude du contrôle de la fréquence cardiaque et de la ventilation cours des exercices passif et actif chez l’Homme.” C.R. Acad. Sei. (Paris) 252:2012–14 (1961).

    CAS  Google Scholar 

  • Dejours, P., Raynaud, J., Cuenod, C. L., and Labrousse, Y., “Modifications instantanées de la ventilation au début et à l’arrêt de l’exercice musculaire. Interpretation.” J. Physiol. (Paris) 47:155–159 (1955).

    CAS  Google Scholar 

  • Harrison, W. G., Jr., Calhoun, J. A., Harrison, T. R., “Afferent impulses as a cause of increased ventilation during muscular exercise.” Am. J. Physiol. 100:68–73 (1932).

    Google Scholar 

  • Hornbein, T. F., Sorensen, S. C., and Parks, C. R., “Role of muscle spindles in lower extremities in breathing during bicycle exercise.” J. Appl. Physiol. 27:4, 476–79 (1969).

    PubMed  CAS  Google Scholar 

  • Hütt, B. K., Horvath, S. M., and Spurr, G. B., “Influence of varying degrees of passive limb movements on respiration and oxygen consumption of man.” J. Appl. Physiol. 12: 297–300 (1958).

    PubMed  Google Scholar 

  • Kao, F. F., “The regulation of breathing during muscular exercise in man. A neurohumoral theory.” In The regulation of human respiration. D. J. C. Cunningham and Lloyd. eds. Oxford: Blackwell Scientific Publications (1963).

    Google Scholar 

  • Kao, F. F., Schlig, B., and Mac Brooks, C., “Regulation of respiration during induced muscular work in decerebrate dogs.” J. Appl. Physiol. 7:379–86 (1955).

    PubMed  CAS  Google Scholar 

  • Krogh, A., and Lindhard, J., “The regulation of respiration and circulation during the initial stages of muscular work.” J. Physiol. (London) 47:112–36 (1913).

    CAS  Google Scholar 

  • Nielsen, M., and Asmussen, E. In The regulation of human respiration. Oxford: Blackwell Scientific Publications (1963).

    Google Scholar 

  • Teillac, A., and Lefrancois, R., “Analyse des réactions ventilatoires aux cours des périodes d’adaption et de récupération de l’exercice musculaire chez l’Homme.” J. Physiol. (Paris) 54:417–18 (1962).

    CAS  Google Scholar 

  • Wigertz, O., “Dynamics of ventilation and heart rate in response to sinusoidal work load in man.” J. Appl. Physiol 29:208–18 (1970).

    PubMed  CAS  Google Scholar 

(9) Technology

  • Bargeton, D., “Analysis of capnigram and oxigram in man.” Bull Physio. Path. Resp. (Nancy) 3:503–26 (1967).

    Google Scholar 

  • Bargeton, D., De Lattre, J., Durand, J. Y., and Florentin, E., “Montages analogiques permettant la détermination continue cycle par cycle des paramètres alveolaires.” Génie biologique et medical 1:142–46 (1970).

    Google Scholar 

  • Barres, G., De Lattre, J., Duhaze, P., and Durand, J. Y., “Une chaîne de pneumotachographie fournissant directement les résultats dans les conditions alvéolaires.” J. Physiol. (Paris) 58:646–47 (1966).

    Google Scholar 

  • Fenn, W. O., and Craig, A. B., Jr., “Effect of CO2 on respiration using a new method of administering CO2.” J. Appl. Physiol 18: 1023–24 (1963).

    PubMed  CAS  Google Scholar 

  • De Lattre, J., Florentin, E., and Bargeton, D., “Enregistrement continu cycle par cycle des paramètres alvéolaires.” J. Physiol (Paris) 61:115–16 (1969).

    Google Scholar 

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Authors and Affiliations

  1. Département de Physiologie Humaine, Faculté de Médecine, U.E.R. Biomédicale Paris-Sts Perès and U 81 INSERM, 45 rue des Sts Pères, 75 Paris VIè, France

    Daniel Bargeton, B. Chambille, H. Guenard & J. de Lattre

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Editors and Affiliations

  1. College of Physicians and Surgeons, Columbia University, New York, New York, USA

    Gabriel Nahas

  2. Submarine Medical Research Laboratory, Groton, Connecticut, USA

    Karl E. Schaefer

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© 1974 Springer-Verlag New York Inc.

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Bargeton, D., Chambille, B., Guenard, H., de Lattre, J. (1974). Regulation of the Carbon Dioxide of Arterial Blood by Ventilation. In: Nahas, G., Schaefer, K.E. (eds) Carbon Dioxide and Metabolic Regulations. Topics In Environmental Physiology And Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-9831-1_29

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  • DOI: https://doi.org/10.1007/978-1-4612-9831-1_29

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9833-5

  • Online ISBN: 978-1-4612-9831-1

  • eBook Packages: Springer Book Archive

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