Abstract
Substance P (SP) and substance K (SK), two structurally related neuropeptides belonging to the tachykinin family, are derived from a single preprotachykinin (PPT) gene [1,2]. Recent evidence has suggested that these peptides are probably co-localized within the striatonigral tract [3]. Interactions of SP and dopamine (DA) in the basal ganglia are well known although the exact mechanisms are unclear [4]. DA antagonists decrease striatonigral tachykinins and striatal PPT mRNA levels [5–7; Bannon et al., this volume]. However, there are conflicting reports on effects of DA agonists on striatonigral substance P concentrations [7,8]. No data has been published on the effects of DA agonists on the levels of striatonigral SK or PPT mRNA. The present study attempts to clarify the effect of DA agonists on striatonigral SP and SK biosynthesis.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Nawa H, Hirose T, Takashima H, Inayarna S, Nakanishi S (1983) Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor. Nature 306: 32–34
Nawa H, Kotair H, Nakanishi S (1984) Tissue specific generation of two preprotachykinin mRNAs from one gene by a1ternate RNA sp1icing. Nature 312: 729–734
Lee J-M, McLean S, Maggio JE, Zamir N, Roth RH, Eskay RL, Bannon MJ (1986) The localization and characterization of substance P and substance K in striatonigral neurons. Brain Res 371: 152–154
Bannon MJ, Freeman AS, Chiodo LA, Bunney BS, Roth RH (1985) The biochemical and electrophysiological pharmacology of mesocortical and mesolimbic dopamine neurons. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of Psychopharmacology Vol 19, Plenum Press: New York
Hong JS, Yang H-YT, Costa E (1978) Substance P content of substantia nigra after chronic treatment with antischizophrenic drugs. Neuropharmacol 17: 83–85
Bannon MJ, Lee J-M, Giraud P, Young A, Affolter H-U, Bonner TI (1986) Dopamine antagonist haloperidol decreases substance P, substance K, and preprotachykinin mRNAs in rat striatonigral neurons. J Biol Chern 261: 6640–6642
Hanson GR, Alphs L, Pradhan S, Lovenberg W (1981) Response of striatonigral substance P systems to a dopamine receptor agonist and antagonist. Neuropharmacol 20: 541–548
Ritter JK, Schmidt CJ, Gibb JW, Hanson GR (1984) Increase in substance P-like immunoreactivity within striatal-nigral structures after subacute methamphetamine treatment. J Pharmacol Exp Therap 229: 487–492
Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951) Protein estimation wi th the Fol-in phenol reagent. J Biol Chern 193: 265-275
Deutch AY, Tam S-Y, Roth RH (1985) Footshock and conditioned stress increase DOPAC in the ventral tegmental area but not the substantia nigra. Brain Res 333: 143–146
Mauborgne A, Javoy-Agid F, Legrand JC, Agid Y, Cessalin F (1983) Decrease of substance P-like immunoreactivity in the substantia nigra and pallidum of Parkinsonian brains. Brain Res 268: 167–170
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag New York Inc.
About this paper
Cite this paper
Elliott, P.J., Young, A., Affolter, HU., Bonner, T.I., Bannon, M.J. (1987). Striatonigral Tachykinin Biosynthesis. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_11
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4672-5_11
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-9109-1
Online ISBN: 978-1-4612-4672-5
eBook Packages: Springer Book Archive