Abstract
Until recently, the aim of red cell substitute design has been to simulate, as closely as possible, the properties of the human red blood cell. Current research suggests that duplication of the red cell may be an overly ambitious goal and each product under development has unique features which significantly affect the way in which they transport oxygen to tissue. Recognizing that human red cells are transfused for a wide variety of clinical indications, it is tempting to match the properties of red cell substitutes to various clinical settings. Doing so, while not precise at the moment, can help guide further research and development efforts and lead to more rational design of new products.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bakker, J.C, GA. Berbers, W.K. Bleeker, P.J. denBoer, and P.T. Biessels. Preparation and characterization of crosslinked and polymerized hemoglobin solutions. Biomat. Artif. Cells Immobil. Biotech. 20: 233–241, 1992.
Braun, R.D., RA. Linsenmeier, and T.K. Goldstick. New perfluorocarbon emulsion improves tissue oxygenation in cat retina. J. Appl. Physiol 72: 1960–1968, 1992.
Bauer, C, M. Forster, G. Gros, A. Mosca, M. Perrella, H.S. Rol-lema, and D.Vogel. Analysis of bicarbonate binding to crocodilian hemoglobin. J. Biol Chem. 256: 8429–8435, 1981.
Chang, T.M.S. Semi-permeable microcapsules. Science 146: 524–525, 1964.
Clark, L.C., and F. Gollan. Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure. Science 152: 1755–1756, 1966.
Federspiel, W.J., and AS. Popel. A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries. Micro-vase. Res. 32: 164–189, 1986.
Fratantoni, J. Demonstration of the effiacy of a therapeutic agent. In Blood substitutes: Physiological basis of efficacy (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, Eds.) New York: Birkhauser, 1995, p. 20–24.
Fuhrman, B., L.J. Hernan, BA Holm, C.L. Leach, M.C. Papo, and D.M. Steinborn. Perfluorocarbon associated gas exchange (PAGE): Gas ventilation of the perfluorocarbon-filled lung. Artif. Cells, Blood Substitutes, Immobil. Biotech. 22: 1133–1140, 1994.
Gould, SA., A.L. Rosen, L.R. Sehgal, H.L. Sehgal, LA. Langdale, L.M. Krause, C.L. Rice, and W.H. Chamberlin. Fluosol-DA as a red-cell substitute in acute anemia. N. Engl J. Med. 314: 1653–1656, 1986.
Holcroft, J.W. Hypertonic saline/dextran in the treatment for hemorrhage. In Proceedings of the workshop on the assessment of plasma volume expanders. Bethesda, MD: CEBR, FDA, and NHLBI, NIH, 1991, pp. 133–147.
Kaufman, R.J. Clinical development of perfluorocarbon-based emulsions as red cell substitutes. In Blood substitutes: Physiological basis of efficacy (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, Eds.) New York: Birkhauser, 1995, pp. 53–75.
Kluger, R., J. Wodzinska, R.T. Jones, C. Head, T.S. Fujita, and D.T. Shih. Three-point cross-linking: potential red cell substitutes from the reaction of trimesoyl tris(methyl phosphate) with hemoglobin. Biochem. 31: 7551–7559, 1992.
Kramer, G.C., P.R. Perron, D.C. Lindsey, H.S. Ho, RA. Gunther, WA. Boyle, and J.W. Holcroft. Small volume resuscitation with hypertonic saline dextran solution. Surgery 100: 239–247, 1986.
Looker, D., D. Abbott-Brown, P. Cozart, S. Durfee, S. Hoffman, A.J. Mathews, J. Miller-Roehrich, S. Shoemaker, S. Trimble, G. Fermi, N.H. Komiyama, K. Nagai and G.L. Stetler. A human recombinant haemoglobin designed for use as a blood substitute.Nature (Lond) 356: 258–260, 1992.
Marini, MA, G.L. Moore, R.M. Fishman, R. Jesse, F. Medina, S.M. Snell, and A.I. Zegna. Reexamination of the polymerization of pyridoxylated hemoglobin with glutaraldehyde. Biopolymers 29: 871–882, 1990.
Mattrey, R. The potential role of perfluorochemicals (PFCs) in diagnostic imaging. Artif. Cells, Blood Substitutes, Immobil. Biotech. 22: 295–314, 1994.
Nho, K., D. Glower, S. Bredehoeft, H. Shankar, R. Shorr, and A. Abuchowski. PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model. Biomat. Artif. Cells Immobil. Biotech. 20: 511–524, 1992.
Rudolph, A.S. The freeze-dried preservation of liposome encapsulated hemoglobin: a potential blood sutstitute. Cryobiology 25: 277–284, 1988.
Rudolph, A.S. Encpsulation of hemoglobin in liposomes. In Blood substitutes: Physiological basis of efficacy (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, Eds.) New York: Birkhauser, 1995, pp. 90–104.
Spence, R., E.D. Norcross, J. Costabile, S. McCoy, A.C. Cernaianu, J.B. Alexander, M.J. Pello, U. Atabeck, and R.C. Camishion. Perfluorocarbons as blood substitues: The early years. Experience with Fluosol Da-20% in the 1980s. Artif. Cells, Blood Substitutes, Immobil. Biotech. 22: 955–964, 1994.
Tsai, A., H. Kerger, and M. Intaglietta. Microcirculatory consequences of blood substitution. In Blood substitutes: Physiological basis of efficacy (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, Eds.) New York: Birkhauser, 1995, pp. 155–174.
Vandegriff, K.D., D.F.H. Wallach, and R.M. Winslow. Encapsulation of hemoglobin in non-phospholipid vesicles. Artif. Cells, Blood Substitutes, Immobil. Biotech. 22(3):849–844, 1994.
Vandegriff, K.D., and R.M. Winslow. A theoretical analysis of oxygen transport: A new strategy for the design of hemoglobin-based red cell substitutes. In Blood substitutes: Physiological basis of efficacy (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, Eds.) New York: Birkhauser, 1995, pp. 143–154.
Walker, JA., R.H. Zaugg, R.Y. Walder, J.M. Steele, and I.M. Klotz. Diaspirins that cross-link B chains of hemoglobin: bis(3,5-dibromo- sali-cyl) succinate and bis(3,5-dibromosalicyl) fumarate. Biochemistry 18: 4265–4270, 1979.
Wall, T.C., R.M. Califf, J. Blankenship, J.D. Talley, M. Tannen-baum, M. Schwaiger, G. Gacioch, M.D. Cohen, M. Sanz, J.D. Leim-berger, and E.J. Topol. Intravenous Fluosol in the treatment of acute myocardial infarction. Results of the Thrombolysis and Angioplasty in Myocardial Infarction 9 Trial. TAMI 9 Research Group. Circulation 90: 114–120, 1994.
Wallach, D.F.H., and J.R. Philippot. New type of lipid vesicle: Novasomes(tm). In Liposome technology: Liposome preparation and related techniques (G. Gregoriadis, Ed.). Boca Raton: CRC Press, 1993, pp. 141–156.
Winslow, R.M. Hemoglobin-based red cell substitutes. Baltimore: Johns Hopkins University Press, 1992.
Winslow, R.M. A physiologic basis for the transfusion trigger. In Blood substitutes: Physiological basis of efficacy (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, Eds.) New York: Birkhauser, 1995, pp. 25–41.
Winslow, R.M., M. Samaja, and J.B. West. Red cell function at extreme altitude on Mount Everest. J. Appl. Physiol. 56: 109–116, 1984.
Winslow, R.M., M.L. Swenberg, J. Benson, M. Perrella, and L. Benazzi. Gas-exchange properties of goat hemoglobin A and C. J. Biol. Chem. 264: 4812–4817, 1989.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Birkhäuser Boston
About this chapter
Cite this chapter
Winslow, R.M. (1996). Blood Substitute Oxygen Carriers Designed for Clinical Applications. In: Winslow, R.M., Vandegriff, K.D., Intaglietta, M. (eds) Blood Substitutes. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4114-0_4
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4114-0_4
Publisher Name: Birkhäuser Boston
Print ISBN: 978-1-4612-8659-2
Online ISBN: 978-1-4612-4114-0
eBook Packages: Springer Book Archive