Abstract
Genetic factors have been reported to account for a large percentage of the variance in peak bone mass in the general population (1). In some studies, an association between vitamin D receptor (VDR) alleles and bone density has been demonstrated (2). It is also unclear as to whether this vitamin D genotype (situated on chromosome 12) predisposes to osteoporosis by influencing peak bone mass or by affecting the rate of age-related bone mass (3). A recent report that the VDR genotype may influence calcium absorption could account for inconsistent results observed in calcium supplementation studies in young and older people (4). The estrogen receptor (R) (situated on chromosome 6) gene has also been identified but, as yet, no clear relationship with bone density has been found (5, 6). The aim of the present study was to investigate the possible influences of the allelic variance of VDR and OR gene on bone mineral density changes in teenage girls receiving dairy food supplementation.
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References
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Gilchrist, N.L., Smart, E.J., Turner, J.G., George, P.M., Frampton, C.M. (1998). The Influence of the Vitamin D and Estrogen Receptor Genotypes on Bone Mineral Density Changes in Teenage Girls Supplemented with Dairy Products. In: Burckhardt, P., Dawson-Hughes, B., Heaney, R.P. (eds) Nutritional Aspects of Osteoporosis. Proceedings in the Serono Symposia USA Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2228-6_11
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DOI: https://doi.org/10.1007/978-1-4612-2228-6_11
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