Abstract
Four major mechanisms are considered the prime regulators of the cerebral circulation: metabolic, myogenic, chemical and neurogenic. In addition, recent studies have also suggested that the endothelium may have an important role in the regulation of cerebral blood flow.’ For the past two decades, the neurogenic mecha-nisms that evoke vasomotor effects have been our main field of research. However, more recently, the putative influence of the endothelium has also attracted our attention.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Edvinsson, L., MacKenzie, E. T., and McCulloch, J. (1993) Cerebral Blood Flow and Metabolism, Raven, New York.
Edvinsson, L., Owman, C., and Sjöberg, N.-O. (1976) Brain Res. 115, 337–393.
Edvinsson, L. (1985) Trends Neurosci. 8,126–131.
Allen, J. M., Todd, N., Crockard, H. A., Schon, F., Yeats, J. C., and Bloom, S. R. (1984) Lancet 11, 550–552.
Edvinsson, L., Ekman, R., Jansen, L., Ottosson, A., and Uddman, R. (1987) Ann. Neurol. 21, 431–437.
Edvinsson, L. and Ekman, R. (1984) Peptides 5, 329–331.
Jansen, I., Uddman, R., Hocherman, M., Ekman, R., Jensen, K., Olesen, J., Stiemholm, P., and Edvinsson, L. (1986) Ann. Neurol. 20, 496–501.
Jansen, I., Uddman, R., Ekman, R., Olesen, J., Ottosson, A., and Edvinsson, L. (1992) Peptides 13,527–536.
Coons, A. H., Leduc, E. H., and Connolly, J. M. (1955) J. Exp. Med. 102, 49–60.
Widerlöv, E., Heilig, M., Ekman, R., and Wahlestedt, C. (1988) Nord Psykiatr. Tidsskr. 42,131–137.
Ekman, R. and Tornquist, K. (1985) Invest. Ophtalmol. Visual. Sci. 26, 1405–1409.
Brodin, E., Lindefors, N. E., Dalsgaard, C.-J., Theodorsson-Norheim, E., and Rosell, S. (1986) Regul. Pept. 13, 253–272.
Grunditz, T., Ekman, R., Hákanson, R., Rerup, C., Sundler, F., and Uddman, R. (1986) Endocrinology 119, 2313–2323.
Högestätt, E. D., Andersson, K.-E., and Edvinsson, L. (1983) Acta Physiol. Scand. 117,49–61.
Nielsen, K. C. and Owman, C. (1967) Brain Res. 6, 773–776.
Edvinsson, L. (1975) Acta Physiol. Scand. (Suppl. 427), 1–35.
Edvinsson, L., Owman, C., Rosengren, E., and West, K. A. (1972) Acta Physiol. Scand. 85, 201–206.
Ekblad, E., Edvinsson, L., Wahlestedt, C., Uddman, R., Hákanson, R., and Sundler, F. (1984) Regul. Pept. 8, 225–235.
Edvinsson, L., Emson, P., McCulloch, J., Tatemoto, K., and Uddman, R. (1983) Neurosci. Lett. 43, 79–84.
Wahlestedt, C., Edvinsson, L., Ekblad, E., and Hákanson, R. (1986) J. Pharmacol. Exp. Ther. 234, 735–741.
Edvinsson, L., Adamsson, M., and Jansen, I. (1990) Neuropeptides 17,99–105.
Kobayashi, S., Kyoshima, K., Olshowka, J. A., and Jacobowitz, D. M. (1983) Histochemistry 79, 377–381.
Edvinsson, L. and McCulloch, J. (1985) Regul. Pept. 10,345–356.
Edvinsson, L., Fahrenkrug, J., Hanko, J., Owman, C., Sundler, F., and Uddman, R. (1980) Cell. Tissue Res. 208,135–142.
Larsson, L. I., Edvinsson, L., Fahrenkrug, J., Hákanson, R., Owman, C., Schaffalitsky de Muckadell, O. B., and Sundler, F. (1976) Brain Res. 113, 400–404.
Matsuyama, T., Shiosaka, S., Matsumoto, M., Yoneda, S., Kimura, K., Abe, H., Hayakawa, T., Inowe, H., and Tohyama, M. (1983) Neuroscience 10, 89–96.
Hara, H., Hamill G. S., and Jacobowitz, D. (1985) Brain Res. 14,179–188.
Suzuki, N., Hardebo, J. E., and Owman, C. (1990) J. Cereb. Blood Flow Metab. 10,399–408.
Miao, F. J.-P. and Lee, T. J.-P. (1990) Cereb. Blood Flow Metab. 10,32–37.
Hara, H. and Weir, B. (1986) Comp. Neurol. 250,245–252.
Saito, A., Wu, J.-Y., and Lee, T. J.-F. (1985) Cereb. Blood Flow Metab. 5, 327–334.
Keller, J. T., Boduk A., and Saunders, M. C. (1985) Neurosci. Lett. 58, 263–268.
Walters, B. B., Gillespie, S. A., and Moskowitz, M. A. (1986) Stroke 17, 488–494.
Edvinsson, L., Hara, H., and Uddman, R. (1989) Cereb. Blood Flow Metab. 9, 212–218.
Suzuki, N., Hardebo, J. E., and Owman, C. (1988) Cereb. Blood Flow Metab. 8, 697–712.
Huang, M. and Rorstad, O. P. (1984) J. Neurochem. 43, 849–856.
Edvinsson, L., Fredholm, B. B., Hamel, E., Jansen, I., and Verrecchia, C. (1985) Neurosci. Lett. 58, 213–217.
Furchgott, R. F. and Zawadzki, J. V. (1980) Nature 288, 373–376.
Hamel, E. and Estrada, C. (1989) Neurotransmission and Cerebrovascular Function II (Seylaz, J. and Sercombe, R., eds.), Elsevier, Amsterdam, pp. 151–173.
Heistad, D. D., Marcus, M. L., Said, S. I., and Gross, P. (1980) Am J. Physiol. 239, 73–80.
Lee, T. J.-F., Saito, A., and Berezin, I. (1984) Science 224, 898–901.
Fahrenkrug, J. (1987) Scand. J. Clin. Lab. Invest. 47 (Suppl. 186), 43–50.
Poulin, P., Suzuki, Y., Lederis, K., and Rorstad, O. P. (1986) Brain Res. 381, 382–384.
Edvinsson, L., McCulloch, J., and Uddman, R. (1981) J. Physiol. 318, 251–258.
Uddman, R., Edvinsson, L., Owman, C., and Sundler, F. (1981) J. Cereb. Blood Flow Metab. 1, 227–232.
Gibbins, I. L., Furness, J. B., Costa, M., Maclntyre, I., Hillyard, C. J., and Girgis, S. (1985) Neurosci. Lett. 57,125–130.
Hanko, J., Hardebo, J. E., Káhrström, J., Owman, C., and Sundler, F. (1985) Neurosci. Lett. 57,91–95.
Uddman, R., Edvinsson, L., Ekman, R., McCulloch, J., and Kingman, T. A. (1985) P. Neurosci. Lett. 62,131–136.
Lee, T., Kawai, Y., Shiosaka, S., Takami, K., Kiyama, H., Hillyard, C. J., Girgis, S., Maclntyre, I., Emson, P. C., and Tohyama, M. (1985) Brain Res. 330,194–196.
Lee, C.-M., Campbell, N. J., Williams, B. J., and Iversen, L. L. (1986) Eur. J. Phamacol. 130, 209–217.
Regoli, D., Drapeau, G., Dion, S., and D’Orleans-Juste, P. (1987) Life Sci. 40,109–117.
Jansen, I., Alafaci, C., McCulloch, J., Uddman, R., and Edvinsson, L. (1991) J. Cereb. Blood Flow Metab. 11,567–575.
Donoso, V. M., Fournier, A., St. Pierre, and Huidobro-Toro, J. P. (1990) Peptides 11, 885–889.
Dennis, T., Fournier, A., Cadieux, A., Pomerleau, F. B., Jolicoeur, F. B., St. Pierre, and Quirion, R. (1990) J. Pharmacol. Exp. Ther. 254,123–128.
Jansen, I. (1992) Neuropeptides 21, 73–79.
Markowitz, S., Saito, K., and Moskowitz, M. A. (1987) J. Neurosci. 4129–4136.
McCulloch, J., Uddman, R., Kingman, T. A., and Edvinsson, L. (1986) Proc. Natl. Acad. Sci. USA 83,5741–5745.
Goadsby, P. J., Edvinsson, L., and Ekman, R. (1990) Ann. Neurol. 28, 183–187.
Goadsby, P. J. and Edvinsson, L. (1991) Cephalalgia 11 (Suppl. 11), 3–4.
Juul, R., Edvinsson, L., Gisvold, S. E., Ekman, R., Brubakk, A. O., and Fredriksen, T. A. (1990) Br. J. Neurosurg. 4,171–180.
Juul, R., Gisvold, S. E., Brubakk, A. O., Fredriksen, T., Waldemar, G., Schmidt, J. F., Ekman, R., and Edvinsson, L. (1993) Regul. Pept. (submitted).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Edvinsson, L., Gulbenkian, S., Jansen, I., Uddman, R. (1994). Neuropeptides in Human Cerebral Arteries. In: Bevan, R.D., Bevan, J.A. (eds) The Human Brain Circulation. Vascular Biomedicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0303-2_4
Download citation
DOI: https://doi.org/10.1007/978-1-4612-0303-2_4
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4612-6700-3
Online ISBN: 978-1-4612-0303-2
eBook Packages: Springer Book Archive