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Placenta Growth Factor

  • Chapter
Vascular Morphogenesis in the Female Reproductive System

Part of the book series: Cardiovascular Molecular Morphogenesis ((CARDMM))

Abstract

The search for regulators of angiogenesis has led to the identification of a number of genes that, when tested in vitro or in vivo (in animal models), help to elucidate the complex phenomenon of vascular formation during development and pathologic conditions. Many new growth factors and receptors and other molecules previously thought to be specific for other systems (e.g., the nervous system) have now been found to play a role in angiogenesis and are currently under analysis. One such example is neuropilin-1, which is expressed predominantly in developing neurons (for a review see Fujisawa and Kitsukawa, 1998). Neuropilin-1 null mutants die during embryonic development due to disorganization of nerve pathways (Kitsukawa et al, 1997) as well as several vascular defects (Kawasaki et al, 1999).

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References

  • Achen, M. G., Gad, J. M., Stacker, S. A., and Wilks, A. F. 1997. Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development. Growth Factors 15:69–80.

    Article  PubMed  CAS  Google Scholar 

  • Athanassiades, A., and Lala, P. K. 1998. Role of placenta growth factor (PIGF) in human

    Google Scholar 

  • extravillous trophoblast proliferation, migration and invasiveness. Placenta 19:465–473.

    Google Scholar 

  • Barillari, G., Albonici, L., Franzese, O., Modesti, A., Liberati, F., Barillari, P., Ensoli, B.

    Google Scholar 

  • Manzari, V., and Santeusanio, G. 1998. The basic residues of placenta growth factor

    Google Scholar 

  • type 2 retrieve sequestered angiogenic factors into a soluble form. Am. J. Pathol.

    Google Scholar 

  • :1161–1166.

    Google Scholar 

  • Barleon, B., Sozzani, S., Zhou, F., Weich, H. A., Mantovani, A., and MarmĂ©, D. 1996. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87:3336–3343.

    PubMed  CAS  Google Scholar 

  • Bussolino, F., Mantovani, A., and Persico, G. 1997. Molecular mechanisms of blood vessel formation. Trends Biochem. Sci. 22:251–256.

    Article  PubMed  CAS  Google Scholar 

  • Cao, Y., Chen, H., Zhou, L., Chiang, M.-K. Anand-Apte, B., Weatherbee, J. A., Wang, Y., Fang, F., Flanagan, J. G., and Lik-Shing-Tsang, M. 1996a. Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR. J. Biol. Chem. 271:3154–3162.

    Article  CAS  Google Scholar 

  • Cao, Y., Linden, P., Shima, D., Brone, F., and Folkman, J. 1996b. In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. J. Clin. Invest. 98:2507–2511.

    Article  CAS  Google Scholar 

  • Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W., and Nagy, A. 1996. Role of tissue factor in embryonic blood vessel development. Nature 383:73–75.

    Article  PubMed  CAS  Google Scholar 

  • Carmeliet, P., Vincenti, V., Moons, L., Luttun, A., Devy, L., Scholz, D., Brusselmans, K., Bono, F., Dipalma, T., Stalmans, I., Fukao, H., Dewerchin, M., Noel, M., Lutgens, E., Barra, A., Blacher, S., Laux, V., Detmar, M., Herbert, J.-M., Foidart, J.-M., Schaper, W.,Collen, D., Persico, M. G. 2000. Placental growth factor (PLGF): a specific stimulator of VEGF in pathological angiogenesis and arteriogenesis. Submitted.

    Google Scholar 

  • Clark, D. E., Smith, S. K., Licence, D., Evans, A. L., and Charnock-Jones, D. S. 1998. Comparison of expression patterns for placenta growth factor, vascular endothelial growth factor (VEGF), VEGF-B and VEGF-C in the human placenta throughout gestation. J. Endocrinol. 159:459–467.

    Article  PubMed  CAS  Google Scholar 

  • Clauss, M., Weich, H. A., Breier, G., Knies, U., Röckl, W., Waltenberger, J., and Risau, W. 1996. The vascular endothelial growth factor receptor Flt-1 mediates biological activities. J. Biol. Chem. 271:17629–17634.

    Article  PubMed  CAS  Google Scholar 

  • Conn, G., Bayne, M. L., Soderman, D. D., Kwok, P. W., Sullivan, K. A., Palisi, T. M., Hope, D. A., and Thomas, K. A. 1990. Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc. NatL Acad. Sci. USA 87:2628–2632.

    Article  PubMed  CAS  Google Scholar 

  • Cunningham, S. A., Tran, T. M., Arrate, M. P., and Brock, T. A. 1999. Characterization of vascular endothelial cell growth factor interactions with the kinase insert domain-containing receptor tyrosine kinase. J. BioL Chem. 274:18421–18427.

    Article  PubMed  CAS  Google Scholar 

  • Davis-Smyth, T., Chen, H., Park, J., Presta, L. G., and Ferrara, N. 1996. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade. EMBO J. 15:4919–41927.

    PubMed  CAS  Google Scholar 

  • Desai, J., Holt-Shore, V., Torry, R. J., Caudle, M. R., and Torry, D. S. 1999. Signal transduction of biological function of placenta growth factor in primary human trophoblast. BioL Reprod. 60:887–892.

    Article  PubMed  CAS  Google Scholar 

  • DiPalma, T., Tucci, M., Russo, G., Maglione, D., Lago, C. T., Romano, A., Saccone, S., DellaValle, G., De Gregorio, L., Dragani, T. A., Viglietto, G., and Persico, M. G. 1996. The placenta growth factor gene of the mouse. Mamm. Genome 7:6–12.

    Article  PubMed  CAS  Google Scholar 

  • DiSalvo, J., Bayne, M. L., Conn, G., Kwock, P. W., Trivedi, P. G., Soderman, D. D., Palisi, T. M., Sullivan, K. A., and Thomas, K. A. 1995. Purification and characterization of a naturally occurring vascular endothelial growth factor-placenta growth factor. J. BioL Chem. 270:7717–7723.

    Article  PubMed  CAS  Google Scholar 

  • Donnini, S., Machein, M. R., Plate, K. H., and Weich, H. A. 1999. Expression and localization of placenta growth factor and P1GF receptors in human meningiomas. J. Pathol. 189:66–71.

    Article  PubMed  CAS  Google Scholar 

  • Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O’Shea, K. S., Powell-Braxton, L., Hillan, K. J., and Moore, M. W. 1996. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380:439–442.

    Article  PubMed  CAS  Google Scholar 

  • Ferrara, N., and Henzel, W. J. 1989. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 161:851–858.

    Article  PubMed  CAS  Google Scholar 

  • Fong, G. H., Rossant, J., Gertsenstein, M., Breitman, M. L. 1995. Role of the Flt-1 recep-

    Google Scholar 

  • tor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376:66–70. Fujisawa, H., and Kitsukawa, T. 1998. Receptors for collapsin/semaphorins. Curr. Opin.NeurobioL 8:587–592.

    Google Scholar 

  • Gospodarowicz, D., Abraham, J. A., and Schilling, J. 1989. Isolation and characterization of a vascular endothelial mitogen produced by pituitary-derived folliculo stellate cells. Proc. Natl. Acad. Sci. USA 86:7311–7315.

    Article  PubMed  CAS  Google Scholar 

  • Guillemin, K., and Krasnow, M. A. 1997. The hypoxic response: Huffing and HIFing. Cell 89:9–12.

    Article  PubMed  CAS  Google Scholar 

  • Hatva, E., Bohling, T., Jaaskelainen, J., Persico, M. G., Haltia, M., and Alitalo, K. 1996. Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas. Am. J. Pathol. 148:763–775.

    PubMed  CAS  Google Scholar 

  • Hauser, S., and Weich, H. A. 1993. A heparin-binding form of placenta growth factor (P1GF-2) is expressed in human umbilical vein endothelial cells and placenta. Growth Factors 9:259–268.

    Article  PubMed  CAS  Google Scholar 

  • Joukov, V., Pajusola, K., Kaipainen, A., Chilov, D., Lahtinen, I., Kukk, E., Saksela, O., Kalkkinen, N., and Alitalo, K. 1996. A novel vascular endothelial growth factor, VEGFC, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 15:290–298.

    PubMed  CAS  Google Scholar 

  • Kawasaki, T., Kitsukawa, T., Bekku, Y., Matsuda, Y., Sanbo, M., Yagi, T., and Fujisawa, H. 1999. A requirement for neuropilin-1 in embryonic vessel formation. Development 126:4895–4902.

    PubMed  CAS  Google Scholar 

  • Keck, P. J., Hauser, S. D., Krivi, G., Sanzo, K., Warren, T., Feder, J., and Connolly, D. T. 1989. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246:1309–1312.

    Article  PubMed  CAS  Google Scholar 

  • Khaliq, A., Dunk, C., Jiang, J., Shams, M., Li, X. F., Acevedo, C., Weich, H., Whittle, M., and Ahmed, A. 1999. Hypoxia down-regulates placenta growth factor, whereas fetal growth restriction up-regulates placenta growth factor expression: molecular evidence for “placental hyperoxia” in intrauterine growth restriction. Lab. Invest. 79:151–170.

    PubMed  CAS  Google Scholar 

  • Khaliq, A., Foreman, D., Ahmed, A., Weich, H., Gregor, Z., McLeod, D., and Boulton, M. 1998. Increased expression of placenta growth factor in proliferative diabetic retinopathy. Lab. Invest. 78:109–116.

    PubMed  CAS  Google Scholar 

  • Khaliq, A., Li, X. F., Shams, M., Sisi, P., Acevedo, C. A., Whittle, M. J., Weich, H. A., and Asmed, A. 1996. Localization of placenta growth factor (P1GF) in human term placenta. Growth Factors 13:243–250.

    Article  PubMed  CAS  Google Scholar 

  • Kitsukawa, T., Shimiizu, M., Sanbo, M., Hirata, T., Taniguchi, M., Bekku, Y., Yagi, T., and Fujisawa, H. 1997. Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron 19:995–1005.

    Article  PubMed  CAS  Google Scholar 

  • Landgren, E., Schiller, P., Cao, Y., and Claesson-Welsh, L. 1998. Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1. Oncogene 16:359–367.

    Article  PubMed  CAS  Google Scholar 

  • Levy, A. P., Tamargo, R., Brem, H., and Nathans, D. 1989. An endothelial cell growth factor from the mouse neuroblastoma cell line NB 41. Growth Factors 2:9–19.

    Article  PubMed  CAS  Google Scholar 

  • Maglione, D., Guerriero, V., Rambaldi, M., Russo, G., Persico, M. G. 1993b. Translation of the placenta growth factor mRNA is severely affected by a small open reading frame localized in the 5’ untranslated region. Growth Factors 8:141–152.

    Article  CAS  Google Scholar 

  • Maglione, D., Guerriero, V., Viglietto, G., Ferraro, M. G., Aprelikova, O., Alitalo, K., Del Vecchio, S., Lei, K. J., Chou, J. Y., and Persice, M. G. 1993a. Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (P1GF), are transcribed from a single gene of chromosome 14. Oncogene 8:925–931.

    CAS  Google Scholar 

  • Maglione, D., Guerriero, V., Viglietto, G., Delli-Bovi, P., and Persico, M. G. 1991. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc. Natl. Acad. Sci. USA 88:9267–9271.

    Article  PubMed  CAS  Google Scholar 

  • Migdal, M., Huppertz, B., Tessler, S., Comforti A., Shibuya, M., Reich, R., Baumann, H., and Neufeld, G. 1998. Neuropilin-1 is a placenta growth factor-2 receptor. J. Biol. Chem. 273:22272–22278.

    Article  PubMed  CAS  Google Scholar 

  • Nomura, M., Yamagishi, S., Harada, S., Yamashima, T., Yamashita, J., and Yamamoto, H. 1998. Placenta growth factor (P1GF) mRNA expression in brain tumors. J. Neurooncol. 40:123–130.

    Article  PubMed  CAS  Google Scholar 

  • Olofsson, B., Pajusola, K., von Euler, G., Chilov, D., Alitalo, K., and Eriksson, U. 1996. Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. J. Biol. Chem. 271:19310–19317.

    Article  PubMed  CAS  Google Scholar 

  • Orlandini, M., Marconcini, L., Ferruzzi, R., and Oliviero, S. 1996. Identification of a cfos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family.Proc. Natl. Acad. Sci. USA93:11675–11680.

    Article  PubMed  CAS  Google Scholar 

  • Park, J. E., Chen, H. H., Winer, J., Houck, K. A., and Ferrara, N. 1994. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity,in vitroandin vivo,and high affinity binding to Flt-1 but not to VEGFR-2.J. Biol. Chem. 269:2564625654.

    Google Scholar 

  • Persico, M. G., Vincenti, V., and DiPalma, T. 1999. Structure, expression and receptor-binding properties of placenta growth factor (P1GF). Curr. Top. Microbiol. Immunol. 237:31–40.

    Article  PubMed  CAS  Google Scholar 

  • Ratajczak, M. Z., Ratajczak, J., Machalinski, B., Majka, M., Marlicz, W., Carter, A., Pietrzkowski, Z., and Gewirtz, A. M. 1998. Role of vascular endothelial growth factor (VEGF) and placenta-derived growth factor (P1GF) in regulating human haemopoietic cell growth.Br. J. Haematol. 103:969–979.

    Article  PubMed  CAS  Google Scholar 

  • Sato, K., Yamazaki, K., Shizume, K., Kanaji, Y., Obara, T., Ohsumi, K., Demura, H., Yamaguchi, S., and Shibuya, M. 1995. Stimulation by thyroid-stimulating hormone and Graves’ immunoglobulin G of vascular endothelial growth factor mRNA expression in human thyroid follicles in vitro and flt mRNA expression in the rat thyroid in vivo.J. Clin. Invest.96:1295–1302.

    Article  PubMed  CAS  Google Scholar 

  • Sawano, A., Takahashi, T., Yamaguchi, S., Aonuma, M., and Shibuya, M. 1996. Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is releated to vascular endothelial growth factor.Cell Growth Differ.7:213–221.

    PubMed  CAS  Google Scholar 

  • Shalaby, F. Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X. F., Breitman, M. L., and Schuh, A. C. 1995. Failure of blood-island formation and vasculogenesis in Flk-1deficient mice.Nature 376:62–66.

    Article  PubMed  CAS  Google Scholar 

  • Shibuya, M., Ito, N., and Claesson-Welsh, L. 1999. Structure and function of vascular endothelial growth factor receptor-1 and -2.Curr. Top. Microbiol. Immunol. 237:5984.

    Google Scholar 

  • Shore, V. H., Wang, T. H., Wang, C. L., Torry, R. J., Caudle, M. T., and Torry, D. S. 1997. Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast.Placenta18:657–665.

    Article  PubMed  CAS  Google Scholar 

  • Simpson, D. A., Murphy, G. M., Bhaduri, T., Gardiner, T. A., Archer, D. B., and Stitt, A. W. 1999. Expression of the VEGF gene family during retinal vaso-obliteration and hypoxia. Biochem. Biophys. Res. Commun. 262:333–340.

    Article  PubMed  CAS  Google Scholar 

  • Sowter, H. M., Corps, A. N., Evans, A. L., Clark, D. E., Charnock-Jones, D. S., and Smith, S. K. 1997. Expression and localization of the vascular endothelial growth factor family in ovarian epithelial tumors.Lab Investigation77:607–614.

    CAS  Google Scholar 

  • Taipale, J., Makinen, T., Arighi, E., Kukk, E., Karkkainen, M., and Alitalo, K. 1999. Vascular endothelial growth factor receptor-3. Curr. Top. Microbiol. Immunol. 237:85–96.

    Article  PubMed  CAS  Google Scholar 

  • Takahashi, A., Sasaki, H., Kim, S. J., Tobisu, K., Kakizoe, T., Tsukamoto, T., Kumamoto, Y., Sugimura, T., and Terada, M. 1994. Markedly increased amount of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res. 54:4233–4237.

    PubMed  CAS  Google Scholar 

  • Terman, B. I., Khandke, L., Dougher-Vermazan, M., Maglione, D., Lassam, N. J., Gospodarowicz, D., Persico, M. G., Bohlen, P., and Eisinger, M. 1994. VEGF receptor subtypes KDR and FLT1 show different sensitivities to heparin and placenta growth factor. Growth Factors 11:187–195.

    Article  PubMed  CAS  Google Scholar 

  • Torry, D. S., Wang, H. S., Wang, T. H., Caudle, M. R., and Torry, R. J. 1998. Preeclampsia is associated with reduced serum levels of placenta growth factor. Am. J. Obstet. Gynecol. 179:1539–1544.

    Article  PubMed  CAS  Google Scholar 

  • Viglietto, G., Maglione, D., Rambaldi, M., Cerutti, J., Romano, A., Trapasso, F., Fedele, M., lppolito, P., Chiappetta, G., Botti, G., Fusco, A., and Persico, M. G. 1995. Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (P1GF) associated with malignancy in human thyroid tumors and cell lines. Oncogene 11:1569–1579.

    PubMed  CAS  Google Scholar 

  • Viglietto, G., Romano, A., Maglione, D., Rambaldi, M., Paoletti, I., Lago, C. T., Califano, D., Monaco, C., Mineo, A., Santelli, G., Manzo, G., Botti, G., Chiappetta, G., and Persico, M. G. 1996. Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta growth factor. Oncogene 13:577–587.

    PubMed  CAS  Google Scholar 

  • Viglietto, G., Romano, A., Manzo, G., Chiappetta, G., Paoletti, I., Califano, D., Galati, M. G., Mauriello, V., Bruni, P., Lago, C. T., Fusco, A., and Persico, M. G. 1997. Upregulation of the angiogenic factors P1GF, VEGF and their receptors (Flt-1, Flk-1/KDR) by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter hypervascularization. Oncogene 15:2687–2698.

    Article  PubMed  CAS  Google Scholar 

  • Vuorela, P., Hatva, E., Lymboussaki, A., Kaipainen, A., Joukov, V., Persico, M. G., Alitalo, K., and Halmesmäki, E. 1997. Expression of vascular endothelial growth factor and placenta growth factor in human placenta. Biol. Reprod. 56:489–494.

    Article  PubMed  CAS  Google Scholar 

  • Vuorela-Vepsäläinen, P., Alfthan, H., Orpana, A., Alitalo, K., Stenman, U.-H., and Halmesmäki, E. 1999. Vascular endothelial growth factor is bound in amniotic fluid and maternal serum. Hum. Reprod. 14:1346–1351.

    Article  PubMed  Google Scholar 

  • Wise, L. M., Veikkola, T., Mercer, A. A., Savory, L. J., Fleming, S. B., Caesar, C., Vitali, A., Makinen, Y., Alitalo, K., and Stacker, S. A. 1999. Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. Proc. Natl. Acad. Sci. USA 96:3071–3076.

    Article  PubMed  CAS  Google Scholar 

  • Yonekura, H., Sakurai, S., Liu, X., Migita, H., Wang, H., Yamagishi, S., Nomura, M., Abedin, Md. J., Unoki, H., Yamamoto, Y., and Yamamoto, H. 1999. Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. J. Biol. Chem. 274:35172–35178.

    Article  PubMed  CAS  Google Scholar 

  • Ziche, M., Maglione, D., Ribatti, D., Morbidelli, L., Lago, C. T., Battisti, M., Paoletti, I., Barra, A., Tucci, M., Parise, G., Vincenti, V., Granger, H. J., Viglietto, G., and Persico, M. G. 1997. Placenta growth factor-1 is chemotactic, mitogenic and angiogenic. Lab. Invest. 76:517–531.

    PubMed  CAS  Google Scholar 

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  1. M. Graziella Persico
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Editors and Affiliations

  1. Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg, D-79106, Germany

    Hellmut G. Augustin

  2. Department of Obstetrics and Gynaecology, Monash Medical Centre, Victoria, 3168, Australia

    Peter A. W. Rogers

  3. Molecular Biology Institute, University of California, Los Angeles, CA, 90095-1570, USA

    M. Luisa Iruela-Arispe

  4. Department of Obstetrics and Gynaecology, Rosie Maternity Hospital, Cambridge, CB2 2SW, England

    Stephen K. Smith

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Persico, M.G. (2001). Placenta Growth Factor. In: Augustin, H.G., Rogers, P.A.W., Iruela-Arispe, M.L., Smith, S.K. (eds) Vascular Morphogenesis in the Female Reproductive System. Cardiovascular Molecular Morphogenesis. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-0213-4_16

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  • DOI: https://doi.org/10.1007/978-1-4612-0213-4_16

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