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Surgical and Medical Therapy for Malignant Pleural Mesothelioma

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Difficult Decisions in Thoracic Surgery

Part of the book series: Difficult Decisions in Surgery: An Evidence-Based Approach ((DDSURGERY,volume 1))

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Abstract

Malignant pleural mesothelioma is a relatively rare but aggressive form of cancer arising from pleural mesothelial cells. Current medical therapy consists of pemetrexed-based chemoradiotherapy and radiotherapy alone. Additionally, a number of novel biological and immunotherapy agents are being developed. Surgical interventions can be categorized according to technique and intent. Selected patients with adequate cardiopulmonary reserve and resectable disease may achieve long-term survival from extrapleural pneumonectomy or extended pleurectomy/decortication in the context of multi-modality therapy. The present chapter presents the current evidence on medical and surgical management of malignant pleural mesothelioma based on data from systematic reviews.

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  1. The Systematic Reviews Unit, The Collaborative Research (CORE) Group, Macquarie University, Sydney, Australia

    Christopher Cao MBBS, BSc (Med)

  2. The Baird Institute for Applied Heart and Lung Surgical Research, Sydney, Australia

    Christopher Cao MBBS, BSc (Med)

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Correspondence to Christopher Cao MBBS, BSc (Med) .

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  1. Surgery, University of Chicago, Chicago, Illinois, USA

    Mark K. Ferguson

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Cao, C. (2014). Surgical and Medical Therapy for Malignant Pleural Mesothelioma. In: Ferguson, M. (eds) Difficult Decisions in Thoracic Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach, vol 1. Springer, London. https://doi.org/10.1007/978-1-4471-6404-3_51

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