Abstract
Extensive trauma can lead to the peripheral nerve transection injury. Further reconstruction can be done with the use of the best method: end-to-end coaptation, if this will not cause tension of the approximated trunks. Larger nerve gaps resulted from tissue loss or degeneration, require additional material for the reconstruction. Ideal material acceptable for nerve engraftment is autologous nerve, however the sources of it are limited. Despite well-established method of full-thickness cable-nerve grafting there is still need for research to improve results of functional nerve restoration following grafting, as well as to increase the amount of neural tissue material suitable for reconstruction.
An experimental rat animal model of the single fascicle graft repair of the sciatic nerve gap, had been developed to evaluate the idea of large nerve defect reconstruction with the lowest possible amount of autologous neural material needed for effective nerve regeneration. In this chapter the scientific rational for the use of single fascicle graft nerve repair, description of its rat animal model and summary of our studies done on this model as well as the review of literature will be presented.
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Zielinski, M. (2015). Single Fascicle Graft Repair Model. In: Siemionow, M. (eds) Plastic and Reconstructive Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-6335-0_54
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DOI: https://doi.org/10.1007/978-1-4471-6335-0_54
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