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The Pathophysiology of Headache

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Headache

Part of the book series: Clinical Medicine and the Nervous System ((CLIN.MED.NERV.))

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Abstract

We still know remarkably little about the pathogenesis of any of the forms of headache that do not have clear-cut structural abnormalities. Over the years a large number of investigators have studied the problem, but unfortunately their observations have tended to become submerged in an excess of speculation. Many of these “unifying hypotheses” are undoubtedly incorrect, and have only served to make matters unnecessarily complicated. In this account an attempt will be made to discuss objective pathophysiological facts, paying less attention to ideas not yet supported by clinical or experimental evidence.

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References

  • Adams CWM, Orton CC, Zilkha KJ (1968) Arterial catecholamine and enzyme histochemistry in migraine. J Neurol Neurosurg Psychiatry 31: 50–56

    PubMed  CAS  Google Scholar 

  • Ad Hoc Committee (1962) Classification of headache. JAMA 179: 717–718

    Google Scholar 

  • Anselmi B, Baldi E, Casacci F et al. (1980) Endogenous opioids in cerebrospinal fluid and blood in idiopathic headache sufferers. Headache 20: 294–299

    PubMed  CAS  Google Scholar 

  • Anthony M (1981) Biochemical indices of sympathetic activity in migraine. Cephalalgia 1: 83–89

    PubMed  CAS  Google Scholar 

  • Anthony M, Lance JW (1967) Plasma serotonin in migraine and stress. Arch Neurol 16: 544–552

    PubMed  CAS  Google Scholar 

  • Anthony M, Hinterberger H, Lance JW (1968) Studies of serotonin metabolism in migraine. Proc Aust Assoc Neurol 5: 109–112

    PubMed  CAS  Google Scholar 

  • Appenzeller O. Atkinson RA, Standefer JC (1981) Serum 0-endorphin in cluster headache and common migraine In: Clifford Rose F, Zilkha KJ (eds) Progress in migraine research 1. Pitman, London, pp 106–109

    Google Scholar 

  • Bakal DA, Kaganov JA (1977) Muscle contraction and migraine headache: psychophysiologic comparison. Headache 17: 208–215

    PubMed  CAS  Google Scholar 

  • Bakke M, Tfelt-Hansen P, Olesen J et al. (1982) Action of some pericranial muscles during provoked attacks of common migraine. Pain 14: 121–135

    PubMed  CAS  Google Scholar 

  • Baldi E, Salmon S, Anselmi B et al. (1982) Intermittent hypoendorphinaemia in migraine attack. Cephalalgia 2: 77–81

    PubMed  CAS  Google Scholar 

  • Baumgartner HR, Born GVR (1968) Effects of 5-hydroxytryptamine on platelet aggregation. Nature 218: 137–141

    PubMed  CAS  Google Scholar 

  • Berge O-G (1982) Effects of 5-HT receptor agonists and antagonists on a reflex response to radiant heat in normal and spinally transected rats. Pain 13: 253–266

    PubMed  CAS  Google Scholar 

  • Bickerstaff ER (1984) Complicated migraine In: Clifford Rose F (ed) Progress in migraine research 2. Pitman, London, pp 83–101

    Google Scholar 

  • Blau JN (1978) Migraine: a vasomotor instability of the meningeal circulation, Lancet II: 1136–1139

    Google Scholar 

  • Blau JN (1984) Migraine pathogenesis: the neural hypothesis reexamined. J Neurol Neurosurg Psychiatry 47: 437–442

    PubMed  CAS  Google Scholar 

  • Blau JN, Davis E (1970) Small blood-vessels in migraine. Lancet II: 740–742

    Google Scholar 

  • Blumer D, Heilbronn M (1982) Chronic muscle contraction headache and the pain-prone disorder. Headache 22: 180–183

    PubMed  CAS  Google Scholar 

  • Bousser MG, Baron JC, Iba-Zizen MT et al. (1980) Migrainous cerebral infarction: a tomographic study of cerebral blood flow and oxygen extraction fraction with the oxygen-15 inhalation technique. Stroke 11: 145–148

    PubMed  CAS  Google Scholar 

  • Bradshaw P, Parsons M (1965) Hemiplegic migraine, a clinical study. Q J Med [New Series] 34: 65–85

    CAS  Google Scholar 

  • Carroll JD, Hilton BP (1974) The effects of reserpine injection on methysergide treated control and migrainous subjects. Headache 14: 149–156

    PubMed  CAS  Google Scholar 

  • Chapman LF, Ramos AO, Goodell H et al. (1960) A humoral agent implicated in vascular headache of the migraine type. Arch Neurol 3: 223–229

    PubMed  CAS  Google Scholar 

  • Cleeland CS, Shacham S, Dahl JL et al. (1984) CSF fl-endorphin and the severity of pain. Neurology 34: 378–380

    PubMed  CAS  Google Scholar 

  • Clement-Jones V, McLoughlin L, Tomlin S et al. (1980) Increased 0-endorphin but not metenkephalin levels in human cerebrospinal fluid after acupuncture for recurrent pain. Lancet II: 946–947

    Google Scholar 

  • Clifford T, Lauritzen M, Bakke M et al. (1982) Electromyography of pericranial muscles during treatment of spontaneous common migraine attacks. Pain 14: 137–147

    PubMed  CAS  Google Scholar 

  • Coppen A, Swade C, Wood K (1979) Platelet 5-hydroxytryptamine accumulation and migraine. Lancet II: 914

    Google Scholar 

  • Corash L, Shafer B, Perlow M (1978) Heterogeneity of human whole blood platelet subpopulations. II. Use of a subhuman primate model to analyze the relationship between density and platelet age. Blood 52: 726–734

    Google Scholar 

  • Couch JR, Hassanein RS (1977) Platelet aggregability in migraine. Neurology 27: 843–848

    PubMed  CAS  Google Scholar 

  • Curran DA, Hinterberger H, Lance JW (1965) Total plasma serotonin 5-hydroxyindoleacetic acid and p-hydroxy-m-methoxymandelic acid excretion in normal and migrainous subjects. Brain 88: 997–1008

    PubMed  CAS  Google Scholar 

  • Curzon G, Theaker P, Phillips B (1966) Excretion of 5-hydroxyindolyl acetic acid ( SHIAA) in migraine. J Neurol Neurosurg Psychiatry 29: 85–90

    Google Scholar 

  • Curzon G, Barrie M, Wilkinson MIP (1969) Relationships between headache and amine changes after administration of reserpine to migrainous patients. J Neurol Neurosurg Psychiatry 32: 555–561

    PubMed  CAS  Google Scholar 

  • Damasio H, Beck D (1978) Migraine, thrombocytopenia, and serotonin metabolism. Lancet I: 240–242

    Google Scholar 

  • D’Andrea G, Toldo M, Cortelazzo S et al. (1982) Platelet activity in migraine. Headache 22: 207–212

    PubMed  Google Scholar 

  • D’Andrea G, Toldo M, Cananzi A et al. (1984) Study of platelet activation in migraine: control by low doses of aspirin. Stroke 15: 271–275

    PubMed  Google Scholar 

  • De Clerck FF, Herman AG (1983) 5-Hydroxytryptamine and platelet aggregation. Fed Proc 42: 228–232

    Google Scholar 

  • Deshmukh SV, Meyer J (1977) Cyclic changes in platelet dynamics and the pathogenesis and prophylaxis of migraine. Headache 17: 101–108

    PubMed  CAS  Google Scholar 

  • Deshmukh SV, Meyer JS, Mouche RJ (1976) Platelet dysfunction in migraine: effect of self-medication with aspirin. Thromb Haemost 36: 319–324

    PubMed  CAS  Google Scholar 

  • Dexter SL (1982) Rebreathing aborts migraine attacks. Br Med J 284: 312

    CAS  Google Scholar 

  • Drummond PD, Lance JW (1983) Extracranial vascular changes and the source of pain in migraine headache. Ann Neurol 13: 32–37

    PubMed  CAS  Google Scholar 

  • Drummond PD, Lance JW (1984) Facial temperature in migraine, tension-vascular and tension headache. Cephalalgia 4: 149–158

    PubMed  CAS  Google Scholar 

  • Dukes HT, Vieth RG (1964) Cerebral arteriography during migraine prodrome and headache. Neurology 14: 636–639

    PubMed  CAS  Google Scholar 

  • Dvilansky A, Rishpon S, Nathan I et al. (1976) Release of platelet 5-hydroxytryptamine by plasma taken from patients during and between migraine attacks. Pain 2: 315–318

    PubMed  CAS  Google Scholar 

  • Edvinsson L, Fahrenkrug J, Hanko J (1980) VIP (vasoactive intestinal polypeptide)-containing nerves of intracranial arteries in mammals. Cell Tissue Res 208: 135–142

    PubMed  CAS  Google Scholar 

  • Edvinsson L, Tfelt-Hansen P, Skarby T et al. (1983) Presence of alpha-adrenoceptors in human temporal arteries. Comparison between migraine patients and controls. Cephalalgia 3: 219–224

    PubMed  CAS  Google Scholar 

  • Elkind AH, Friedman AP, Grossman J (1964) Cutaneous blood flow in vascular headaches of the migraine type. Neurology 14: 24–30

    PubMed  CAS  Google Scholar 

  • Facchinetti F, Nappi G, Savoldi F et al. (1981) Primary headaches: reduced circulating 0-lipotropin and 1-endorphin levels with impaired reactivity to acupuncture. Cephalalgia 1: 195–201

    PubMed  CAS  Google Scholar 

  • Fettes I, Gawel M, Kuzniak S et al. (1985) Endorphin levels in headache syndromes. Headache 25: 37–39

    PubMed  CAS  Google Scholar 

  • Fields HL (1981) Pain II: new approaches to management. Ann Neurol 9: 101–106

    PubMed  CAS  Google Scholar 

  • Fitscha P, Sinzinger H (1984) Platelet hyperactivity during acute migraine attack. Vasa 13: 224–227

    PubMed  CAS  Google Scholar 

  • Fozard JR (1982) Serotonin, migraine and platelets. Prog Pharmacol 4: 135–146

    CAS  Google Scholar 

  • Frojmovic MM, Milton JG (1982) Human platelet size, shape, and related functions in health and disease. Physiol Rev 62: 185–261

    PubMed  CAS  Google Scholar 

  • Gardner-Medwin AR (1981) Possible roles of vertebrate neuroglia in potassium dynamics, spreading depression and migraine. J Exp Biol 95: 111–127

    PubMed  CAS  Google Scholar 

  • Gawel M, Burkitt M, Clifford Rose F (1979) The platelet release reaction during migraine attacks. Headache 19: 323–327

    PubMed  CAS  Google Scholar 

  • Geaney DP, Rutterford MG, Elliott JM et al. (1984) Decreased platelet 3H-imipramine binding sites in classical migraine. J Neurol Neurosurg Psychiatry 47: 720–723

    PubMed  CAS  Google Scholar 

  • Gelmers HJ (1982) Common migraine attacks preceded by focal hyperemia and perietal oligemia in the rCBF pattern. Cephalalgia 2: 29–32

    PubMed  CAS  Google Scholar 

  • Genazzani AR, Nappi G, Facchinetti F et al. (1984) Progressive impairment of CSF 0-EP levels in migraine sufferers. Pain 18: 127–133

    PubMed  CAS  Google Scholar 

  • Ghose K (1984) Migraine, antimigraine drugs and tyramine pressor test. In: Amery WK, Van Nueten JM, Wauquier A (eds) The pharmacological basis of migraine therapy. Pitman, London, pp 213–229

    Google Scholar 

  • Ghose K, Coppen A, Carroll D (1977) Intravenous tyramine response in migraine before and during treatment with indoramin. Br Med J I: 1191–1193

    Google Scholar 

  • Gotoh F, Kanda T, Sakai F et al. (1976) Serum dopamine-(3-hydroxylase activity in migraine. Arch Neurol 33: 656–657

    PubMed  CAS  Google Scholar 

  • Gotoh F, Komatsumoto S, Araki N et al. (1984) Noradrenergic nervous activity in migraine. Arch Neurol 41: 951–955

    PubMed  CAS  Google Scholar 

  • Graham JR, Wolff HG (1938) Mechanism of migraine headache and action of ergotamine tartrate. Arch Neurol Psychiatry 39: 737–763

    CAS  Google Scholar 

  • Grammeltvedt A, Hovig T, Sjaastad O (1975) Electronmicroscopy of blood platelets in migraine and cluster headache. Headache 14: 226–230

    PubMed  CAS  Google Scholar 

  • Griffith SG, Burnstock G (1983) Immunohistochemical demonstration of serotonin in nerves supplying human cerebral and mesenteric blood-vessels. Lancet I: 561–562

    Google Scholar 

  • Grotemeyer K-H, Viand R, Beykirch K (1983) Thrombozytenfunktion bei vasomotorischen Kopfschmerzen and Migranekopfschmerzen. Dtsch Med Wochenschr 108: 775–778

    PubMed  CAS  Google Scholar 

  • Haigler HG (1982) Characteristics of extravascular serotonin receptors in the brain. Adv Neurol 33: 283–289

    PubMed  CAS  Google Scholar 

  • Hanington E, Jones RJ, Amess JAL et al. (1981) Migraine: a platelet disorder. Lancet II: 720–723

    Google Scholar 

  • Heyck H (1969) Pathogenesis of migraine: a contribution. Res Clin Stud Headache 2: 1–28

    Google Scholar 

  • Heyck H (1981) Vascular shunt mechanisms and migraine pathogenesis. Neurology (NY) 31: 1203–1204

    CAS  Google Scholar 

  • Hilton BP, Cumings JN (1972) 5-Hydroxytryptamine levels and platelet aggregation responses in subjects with acute migraine headache. J Neurol Neurosurg Psychiatry 35: 505–509

    Google Scholar 

  • Hsu LKG, Crisp AH, Kalucy RS et al. (1977) Early morning migraine. Nocturnal plasma levels of catecholamines, tryptophan, glucose, and free fatty acids and sleep encephalographs. Lancet 1: 447–451

    PubMed  CAS  Google Scholar 

  • Hungerford GD, du Boulay GH, Zilkha KJ (1976) Computerised axial tomography in patients with severe migraine: a preliminary report. J Neurol Neurosurg Psychiatry 39: 990–994

    PubMed  CAS  Google Scholar 

  • Jessell TM (1982) Neurotransmitters and CNS disease. Pain. Lancet II: 1084–1088

    Google Scholar 

  • Johnson ES (1978) A basis for migraine therapy-the autonomic theory reappraised. Postgrad Med J 54: 231–242

    PubMed  CAS  Google Scholar 

  • Kalendovsky Z, Austin JH (1977) Changes in blood clotting systems during migraine attacks. Headache 16: 293–312

    PubMed  CAS  Google Scholar 

  • Kaplan KL, Broekman MJ, Chernoff A et al. (1979) Platelet a-granule proteins: studies on release and subcellular localization. Blood 53: 604–618

    PubMed  CAS  Google Scholar 

  • Karpatkin S (1972) Human platelet senescence. Ann Rev Med 23: 101–128

    PubMed  CAS  Google Scholar 

  • Kimball RW, Friedman AP, Vallejo E (1960) Effect of serotonin in migraine patients. Neurology 10: 107–111

    PubMed  CAS  Google Scholar 

  • Kiser RS, Khatami M, Gatchel RJ et al. (1983) Acupuncture relief of chronic pain syndrome correlates with increased plasma met-enkephalin concentrations. Lancet II: 1394–1396

    Google Scholar 

  • Kupersmith MJ, Hass WK, Chase NE (1979) Isoproterenol treatment of visual symptoms in migraine. Stroke 10: 299–305

    PubMed  CAS  Google Scholar 

  • Lambert GA, Bogduk N, Goadsby PJ et al. (1984) Decreased carotid arterial resistance in cats in response to trigeminal stimulation. J Neurosurg 61: 307–315

    PubMed  CAS  Google Scholar 

  • Lance JW, Anthony M (1971) Thermographie studies in vascular headache. Med J Australia 1: 240–243

    PubMed  CAS  Google Scholar 

  • Lance JW, Fine RD, Curran DA (1963) An evaluation of methysergide in the prevention of migraine and other vascular headaches. Med J Aust I: 814–818

    Google Scholar 

  • Lance JW, Lambert GA, Goadsby PJ et al. (1983) Brainstem influences on the cephalic circulation: experimental data from cat and monkey of relevance to the mechanism of migraine. Headache 23: 258–265

    PubMed  CAS  Google Scholar 

  • Lancet (1984) Headache and depression. Lancet I: 495

    Google Scholar 

  • Lashley KS (1941) Patterns of cerebral integration indicated by the scotomas of migraine. Arch Neurol Psychiatry 46: 331–339

    Google Scholar 

  • Laufer N, Grover NB, Ben-Sasson S et al. (1979) Effects of adenosine diphosphate, colchicine and temperature on size of human platelets. Thromb Haemost 41: 491–497

    PubMed  CAS  Google Scholar 

  • Launay JM, Pradalier A, Dreux C et al. (1982) Platelet serotonin uptake and migraine. Cephalalgia 2: 57–59

    PubMed  CAS  Google Scholar 

  • Lauritzen M, Olesen J (1984) Regional cerebral blood flow during migraine attacks by xenon-133 inhalation and emission tomography. Brain 107: 447–461

    PubMed  Google Scholar 

  • Lauritzen M, Jorgensen MB, Diemer NH et al. (1982) Persistent oligemia of rat cerebral cortex in the wake of spreading depression. Ann Neurol 12: 469–474

    PubMed  CAS  Google Scholar 

  • Lauritzen M, Olsen TS, Lassen NA et al. (1983) Changes in regional cerebral blood flow during the course of classic migraine attacks, Ann Neurol 13: 633–641

    PubMed  CAS  Google Scholar 

  • Leao AAP (1944) Spreading depression of activity in the cerebral cortex. J Neurophysiol 7: 359–390

    Google Scholar 

  • Magos A, Brincat M, Zilkha KJ et al. (1985) Serum dopamine l-hydroxylase activity in menstrual migraine. J Neurol Neurosurg Psychiatry 48: 328–331

    PubMed  CAS  Google Scholar 

  • Malmgren R, Olsson P, Tornling G et al. (1978) Acetylsalicylic asthma and migraine—a defect in serotonin (5-HT) uptake in platelets. Thromb Res 13: 1137–1139

    PubMed  CAS  Google Scholar 

  • Manotti C, Quintavalla R, Manzoni GC (1983) Platelet activation in migraine. Thromb Haemost 50: 758

    PubMed  CAS  Google Scholar 

  • Marcussen RM, Wolff HG (1950) Studies on headache 1. Effects of carbon dioxide-oxygen mixture given during preheadache phase of the migraine attacks. 2. Further analysis of the pain mechanisms in headache. Arch Neurol Psychiatry 63: 42–51

    Google Scholar 

  • Martin PR (1980) Behavioural management of headaches: a review of the evidence. Int J Ment Health 9: 88–110

    Google Scholar 

  • Martin PR, Mathews AM (1978) Tension headaches psychophysiological investigation and treatment. J Psychosom Res 22: 389–399

    PubMed  CAS  Google Scholar 

  • Mayberg M, Langer RS, Zervas NT et al. (1981) Perivascular meningeal projections from cat trigeminal ganglia: possible pathway for vascular headaches in man. Science 213: 228–230

    PubMed  CAS  Google Scholar 

  • Miller Fisher C (1971) Cerebral ischemia—less familar types. Clin Neurosurg 18: 267–336

    Google Scholar 

  • Milner PM (1958) Note on a possible correspondence between the scotomas of migraine and spreading depression of Leao. Electroencephalogr Clin Neurophysiol 10: 705

    PubMed  CAS  Google Scholar 

  • Milton JG, Yung W, Frojmovic MM (1981) Dependence of platelet volume measurements on heterogeneity of platelet morphology. Biophys J 35: 257–261

    PubMed  CAS  Google Scholar 

  • Morley S, Hunter M (1983) Temporal artery pulse amplitude wave shapes in migraineurs: a methodological investigation. J Psychosom Res 27: 485–492

    PubMed  CAS  Google Scholar 

  • Moskowitz M (1984) The neurobiology of vascular head pain. Ann Neurol 16: 157–168

    PubMed  CAS  Google Scholar 

  • Mosnaim AD, Chevesich J, Wolf ME et al. (1984) Plasma methionine-enkephalin. A biological marker for migraine? Headache 24: 161

    Google Scholar 

  • Muck-Seler D, Deanovic Z, Dupelj M (1979) Platelet serotonin (5-HT) and 5-HT releasing factor in plasma of migrainous patients. Headache 19: 14–17

    PubMed  CAS  Google Scholar 

  • Mutch WAC, Hansen AJ (1983) Lactate accumulation in brain during spreading depression—further evidence that spreading depression is involved in migraine. Abstracts of 1st International Headache Congress, Munich, 15–16

    Google Scholar 

  • Nappi G, Facchinetti F, Bono G et al. (1982) Plasma opioid levels in post-traumatic chronic headache and trigeminal neuralgia: maintained response to acupuncture. Headache 22: 276–279

    PubMed  CAS  Google Scholar 

  • Nattero G, Lisino F, Brandi G et al. (1976) Reserpine for migraine prophylaxis. Headache 15: 279–281

    PubMed  CAS  Google Scholar 

  • Nattero G, Bulla A, Levi E et al. (1981) Platelet aggregability and migraine: is their relationship a reality? In: Clifford Rose F, Zilkha KJ (eds) Progress in Migraine Research 1. Pitman, London, pp 69–79

    Google Scholar 

  • Neligan P, Harriman DGF, Pearce J (1977) Respiratory arrest in familial hemiplegic migraine: a clinical and neuropathological study. Br Med J II: 732–734

    Google Scholar 

  • Nuechterlein KH, Holroyd JC (1980) Biofeedback in the treatment of tension headache. Arch Gen Psychiatry 37: 866–873

    PubMed  CAS  Google Scholar 

  • O’Brien JR (1978) “Exhausted” platelets continue to circulate. Lancet II: 1316–1317

    Google Scholar 

  • O’Brien MD (1967) Cerebral-cortex-perfusion rates in migraine. Lancet I: 1036

    Google Scholar 

  • O’Brien MD (1973) The haemodynamics of migraine—a review. Headache 12: 160–162

    PubMed  Google Scholar 

  • Olesen J (1982) Is ischemia involved in the pathogenesis of migraine? Path Biol 30: 318–324

    CAS  Google Scholar 

  • Olesen J, Lauritzen M (1984) The role of vasoconstriction in the pathogenesis of migraine. In: Amery WK (ed) The pharmacological basis of migraine therapy. Pitman, London, pp 7–18

    Google Scholar 

  • Olesen J, Tfelt-Hansen P, Henriksen L et al. (1981a) The common migraine attack may not be initiated by cerebral ischaemia. Lancet II: 438–440

    Google Scholar 

  • Olesen J, Larsen B, Lauritzen M (1981b) Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 9: 344–352

    PubMed  CAS  Google Scholar 

  • Ostfeld AM, Wolff HG (1955) Arterenol ( Norepinephrine) and vascular headache of the migraine type. Arch Neurol Psychiatry 74: 131–136

    Google Scholar 

  • Parry CH (1792) On the effects of compression of the arteries in various diseases and particularly in those of the head: with hints towards a new mode of treating nervous disorders. Memoirs of the Medical Society of London 3: 77–113

    Google Scholar 

  • Pearce JMS (1984) Migraine: a cerebral disorder. Lancet II: 86–89

    Google Scholar 

  • Pearce JMS, Foster JB (1965) An investigation of complicated migraine. Neurology 15: 333–340

    PubMed  CAS  Google Scholar 

  • Peatfield RC, Gawel MJ, Clifford Rose F (198la) Asymmetry of the aura and pain in migraine. J Neurol Neurosurg Psychiatry 44: 846–848

    Google Scholar 

  • Peatfield RC, Gawel MJ, Clifford Rose F (1981 b) The effect of infused prostacyclin in migraine and cluster headache. Headache 21: 190–195

    Google Scholar 

  • Peatfield RC, Gawel MJ, Guthrie DL et al. (1982) Platelet size: no correlation with migraine or monoamine oxidase activity. J Neurol Neurosurg Psychiatry 45: 826–829

    PubMed  CAS  Google Scholar 

  • Peatfield R, Littlewood JT, Glover V et al. (1983) Pressor sensitivity to tyramine in patients with headache: relationship to platelet monoamine oxidase and to dietary provocation. J Neurol Neurosurg Psychiatry 46: 827–831

    PubMed  CAS  Google Scholar 

  • Peatfield RC, Fozard JR, Clifford Rose F (1985) Drug treatment of migraine. In: Vinken PJ, Bruyn GW, Klawans HL (eds) Handbook of clinical neurology, vol. 48. Elsevier, Amsterdam (in press) Peelen M (1967) Tolazoline for lumbar-puncture headache. N Engl J Med 277: 987

    Google Scholar 

  • Penington DG, Lee NLY, Roxburgh AE et al. (1976a) Platelet density and size: the interpretation of heterogeneity. Br J Haematol 34: 365–376

    PubMed  CAS  Google Scholar 

  • Penington DG, Streatfield K, Roxburgh AE (1976b) Megakaryocytes and the heterogeneity of circulating platelets. Br J Haematol 34: 639–653

    PubMed  CAS  Google Scholar 

  • Pickering GW (1939) Experimental observation on headache. Br Med J I: 907–912

    Google Scholar 

  • Pikoff H (1984) Is the muscular model of headache still viable? A review of conflicting data. Headache 24: 186–198

    PubMed  CAS  Google Scholar 

  • Pipili E, Poyser NL (1981) Effects of nerve stimulation and of administration of noradrenaline or potassium chloride upon the release of prostaglandins I2, E2 and Fla from the perfused mesenteric arterial bed of the rabbit. Br J Pharmacol 72: 89–93

    PubMed  CAS  Google Scholar 

  • Pradalier A, Launay JM, Dry J et al. (1983) Role de la serotonine plaquettaire dans la migraine commune. Taux et captation. Presse Med 12: 2311–2314

    PubMed  CAS  Google Scholar 

  • Proudfit HK, Hammond DL (1981) Alterations in nociceptive threshold and morphine-induced analgesia produced by intrathecally administered amine antagonists. Brain Res 218: 393–399

    PubMed  CAS  Google Scholar 

  • Roberts MHT, Llewelyn MB (1982) The supraspinal control of pain. Bioscience 32: 587–594 112–113

    Google Scholar 

  • Sakai F, Meyer JS (1978) Regional cerebral hemodynamics during migraine cluster headaches measured by the 1J3Xe inhalation method. Headache 18: 122–132

    PubMed  CAS  Google Scholar 

  • Sandler M (1972) Migraine: A pulmonary disease? Lancet I: 618–619

    Google Scholar 

  • Schroth G, Gerber WD, Langohr HD (1983) Ultrasonic doppler flow in migraine and cluster headache. Headache 23: 284–288

    PubMed  CAS  Google Scholar 

  • Schumacher GA, Wolff HG (1941) Experimental studies on headache A. Contrast of histamine headache with the headache of migraine and that associated with hypertension B. Contrast of vascular mechanisms in preheadache and in headache phenomena of migraine. Arch Neurol Psychiatry 45: 199–214

    Google Scholar 

  • Sicuteri F (1976) Hypothesis: migraine, a central biochemical dysnociception, Headache 16: 145–159

    PubMed  CAS  Google Scholar 

  • Sicuteri F, Testi A, Anselmi B (1961) Biochemical investigations in headache: increase in the hydroxyindoleacetic acid excretion during migraine attacks. Int Arch Allergy 19: 55–58

    CAS  Google Scholar 

  • Sicuteri F, Anselmi B, Del Bianco PL (1973) 5-Hydroxytryptamine supersensitivity as a new theory of headache and central pain: a clinical pharmacological approach with p-chlorophenylalanine. Psychopharmacologia (Berlin) 29: 347–356

    Google Scholar 

  • Sicuteri F, Fanciullacci M, Michelacci S (1978) Decentralization supersensitivity in headache and central panalgesia. Res Clin Stud Headache 6: 19–33

    PubMed  CAS  Google Scholar 

  • Sicuteri F, Boccuni M, Fanciullacci M et al. (1983) Naloxone effectiveness on spontaneous and induced perceptive disorders in migraine. Headache 23: 179–183

    PubMed  CAS  Google Scholar 

  • Sjolund B, Terenius L, Eriksson M (1977) Increased cerebrospinal fluid levels of endorphins after electro-acupuncture. Acta Physiol Scand 100: 382–384

    PubMed  CAS  Google Scholar 

  • Skinhoj E (1973) Hemodynamic studies within the brain during migraine. Arch Neurol 29: 95–98

    PubMed  CAS  Google Scholar 

  • Spierings ELH (1979) Craniovascular accompaniments of the vascular headache of the migraine type. Headache 19: 397–399

    PubMed  CAS  Google Scholar 

  • Spierings ELH, Saxena PR (1980) Antimigraine drugs and cranial arteriovenous shunting in the cat. Neurology 30: 696–701

    PubMed  CAS  Google Scholar 

  • Thompson JK (1982) Diagnosis of head pain: an idiographic approach to assessment and classification. Headache 22: 221–232

    PubMed  CAS  Google Scholar 

  • Thompson JW (1984) Opioid peptides. Br Med J 288: 259–260

    CAS  Google Scholar 

  • Thompson CB, Love DG, Quinn PG et al. (1983) Platelet size does not correlate with platelet age. Blood 62: 487–494

    PubMed  CAS  Google Scholar 

  • Tunis MM, Wolff HG (1953) Studies on headache. Long-term observations of the reactivity of the cranial arteries in subjects with vascular headache of the migraine type. Arch Neurol Psychiatry 70: 551–557

    Google Scholar 

  • Vermylen J, Badenhorst PN, Deckmyn H et al. (1983) Normal mechanisms of platelet function. Clin Haematol 12: 107–151

    PubMed  CAS  Google Scholar 

  • Violi F, Iuliano L, Alessandri C et al. (1984) Beta-thromboglobulin plasma levels in common migraine. Thromb Haemost 51: 295

    PubMed  CAS  Google Scholar 

  • Welch KMA, Spira PJ, Knowles L et al. (1974) Effects of prostaglandins on the internal and external carotid blood flow in the monkey. Neurology 24: 705–710

    PubMed  CAS  Google Scholar 

  • Wetzel NC, Zotterman Y (1926) On differences in the vascular colouration of various regions of the normal human skin. Heart 13: 357–367

    Google Scholar 

  • Witte LD, Kaplan KL, Nossel HL et al. (1978) Studies of the release from human platelets of the growth factor for cultured human arterial smooth muscle cells. Cire Res 42: 402–409

    CAS  Google Scholar 

  • Wu KK, Hoak JC (1974) A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency. Lancet II: 924–926

    Google Scholar 

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© 1986 Springer-Verlag Berlin Heidelberg

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Peatfield, R. (1986). The Pathophysiology of Headache. In: Headache. Clinical Medicine and the Nervous System. Springer, London. https://doi.org/10.1007/978-1-4471-3127-4_9

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  • DOI: https://doi.org/10.1007/978-1-4471-3127-4_9

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  • Print ISBN: 978-3-540-19531-3

  • Online ISBN: 978-1-4471-3127-4

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