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The Innervation of Pial Blood Vessels and their Role in Cerebrovascular Regulation

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Book cover Brain Ischemia

Abstract

Thomas Willis noted in his Cerebri Anatome (1664) that brain vessels were accompanied by fibers. Hovelaque (1927) and Sheehan (Northfield 1938) identified neural connections between the trigeminal ganglion and the internal carotid artery, but were unable to determine whether they represented sympathetic innervation of the trigeminal ganglion or a sensory innervation to the cerebral vessels. Levine and Wolff (1932) demonstrated that electrical stimulation of cat pial arteries increased galvanic skin responses, and that this effect was blocked by the application of procaine to the vessel. Motor end-plates were observed microscopically in the adventitia of pial arteries, and were thought to represent afferent nerve endings (McNaughton 1938). In primates, Wall and Pribram (1950) found that the hypertensive response to electrical stimulation of pial arteries was blocked by trigeminal neurotomy. In man, Fay (1932), Penfield and McNaughton (1940) and Ray and Wolff (1940) elicited forehead pain by electrical stimulation of the pial and dural arteries. However, it was not until the axonal tracing studies of Mayberg and colleagues (1981) that direct connections between the trigeminal nerve and the circle of Willis were documented.

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Authors
  1. R. Macfarlane
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  2. M. A. Moskowitz
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Editors and Affiliations

  1. Department of Neurology, New England Medical Center Hospitals, 750 Washington Street, 02111, NEMCH #314, Boston, Massachusetts, USA

    Louis R. Caplan MD (Professor and Chairman) (Professor and Chairman)

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© 1995 Springer-Verlag London Limited

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Macfarlane, R., Moskowitz, M.A. (1995). The Innervation of Pial Blood Vessels and their Role in Cerebrovascular Regulation. In: Caplan, L.R. (eds) Brain Ischemia. Springer, London. https://doi.org/10.1007/978-1-4471-2073-5_25

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  • DOI: https://doi.org/10.1007/978-1-4471-2073-5_25

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-2075-9

  • Online ISBN: 978-1-4471-2073-5

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