Abstract
The hormonal and metabolic events occurring during an oral glucose load have been extensively characterised in man. The use of tracers, the splanchnic hepatic balance technique and indirect calorimetry [1] have permitted the measurement of most, if not all the kinetic parameters of glucose metabolism. Despite this extensive work the mechanisms involved in the regulation of glycaemia are still the subject of debate and research. Most of the sophisticated methodology used still needs to be applied to various carbohydrate nutrients which are usually transformed inside the body into glucose before being oxidised, stored or recycled. The aim of this short review is not to provide extensive data on the glycaemic index of various carbohydrates, but to focus on the respective roles of hormones and glucose per se, and to underline some remaining methodological problems in this kind of study.
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References
Alberti KGM, Home PD, Taylor R (1987) Technique for metabolic investigation in man, Clin Endocrinol Metab 1: 773–1071
Waldhausl WK, Gasic S, Bratusch-Marrain P, Nowotny P (1983) The 75 g oral glucose tolerance test: effect on splanchnic metabolism of substrates and pancreatic hormone release in healthy man. Diabetologia 25: 484–495
Ferrannini E, Bjorkman O, Reichard GA et al. (1985) The disposal of an oral glucose load in healthy subjects. A quantitative study. Diabetes 34: 580–588
Abumrad NJ, Cherrington AD, Williams PE, Lacy WW, Rabin D (1982) Absorption and disposition of a glucose load in the conscious dog. Am J Physiol 242: E398 — E406
Kelly D, Mitrakou A, March H et al. (1988) Skeletal muscle glycolysis, oxidation and storage of an oral glucose load. J Clin Invest 81: 1563–1571
Jackson RA, Rosmansa RD, Hawa MI, Sim BM, Disilvio I (1986) Impact of glucose ingestion on hepatic and peripheral glucose metabolism in man: An analysis based on simultaneous use of forearm and double isotope techniques. J Clin Endocrinol Metab 63: 541–549
Adkins BA, Myers SR, Hendrick GL, Stevenson RW, Williams PE, Cherrington AD (1987) Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J Clin Invest 79: 557–565
Rizza RA, Mandarino LI, Gerich JE (1981) Dose response characteristics for effects of insulin on production and utilisation of glucose in man. Am J Physiol 240: E630 — E639
Gottesman I, Mandarino L, Gerich J (1984) Use of glucose uptake and glucose clearance for the evolution of insulin action in vivo. Diabetes 33: 184–191
Jacot E, Defronzo A, Jequier E, Maeder E, Felber JP (1982) The effect of hyperglycemia, hyperinsulinemia and route of glucose administration on glucose oxidation and glucose storage. Metabolism 31: 922–990
Randle PJ, Newsholme EA, Garland PB (1964) Regulation of glucose uptake by muscle; effects of fatty acids, ketone bodies and pyruvate and of alloxan diabetes and starvation on the uptake and metabolic fats of glucose in rat heart and diaphragm muscles. Biochem J 93: 657–685
Ferrannini E, Garett EJ, Beuilacqua J, Defronzo RA (1983) Effect of fatty acids on glucose production and utilization in man. J Clin Invest 72: 1737–1747
Jequier E, Felber JP (1987) Role of fats in obesity and type II diabetes mellitus. In: Horisberger M, Bracco U (eds) Lipids in modem nutrition. Raven Press, pp 205–211
Ebiner JR, Acheson KJ, Doemer A (1979) Carbohydrate utilization in man using indirect calorimetry and mass spectometry after an oral load of 100 g naturally labelled 13C glucose. Br J Nutr 41: 419–429
Dix D, Cohen P (1980) Interpretation of the glucose tolerance test. Diabetologia 19: 488–494
Kaden M, Harding P, Field JB (1973) Effect of intraduodenal glucose administration on hepatic extraction of insulin in anesthetized dog. J Clin Invest 52: 2016–2028
Rubinstein AH, Clark JL, Melani F, Steiner D (1969) Secretion of proinsulin and C peptide by pancreatic beta cells and its circulation in blood. Nature 224: 697–699
Polonsky K, Jaspan J, Pugh W et al. (1983) Metabolism of C-peptide in the dog: in vivo demonstration of the absence of hepatic extraction. J Clin Invest 72: 1114–1123
Eaton RP, Allen RC, Schade DS (1983) Hepatic removal of insulin in normal man: dose response to endogenous insulin secretion. J Clin Endocrinol Metab 56: 1294–1301
Polonsky K, Licino-Paixao J, Given BD et al. (1986) Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J Clin Invest 77: 98–105
Faber OK, Madsbad S, Kehlet M, Binder C (1978) Pancreatic beta cell secretion during oral and intravenous glucose administration. Acta Med Scand [Suppl] 624: 61–64
Elrick M, Stimmler L, Mcao C, Arai Y (1964) Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab 24: 1076–1082
McIntyre N, Holdsworth C, Turner P (1965) Intestinal factors in the context of insulin secretion. J Clin Endocrinol 25: 1317–1324
Madsbad O, Kehlet M, Hilsted J, Tronier B (1983) Discrepancy between plasma C-peptide and insulin response to oral and intravenous glucose. Diabetes 32: 436–438
Pipeleers D (1987) The biosociology of pancreatic B cells. Diabetologia 30: 277–291
Trimble ER, Bruzzone R, Gjsnovci A, Renold AE (1985) Activity of the insulo-acinar axis in the isolated perfused pancreas. Endocrinology 117: 1246–1252
Curry DL, Bennett LL, Grodsky GM (1968) Dynamics of insulin secretion by the perfused pancreas. Endocrinology 83: 572–584
Jarrett RI, Keen H (1968) Oxidation of sugars, other than glucose, by isolated mammalian islets of Langerhans Metabolism 17: 155–159
MacDonald MJ, Ball DH, Patel TN, Lauris V, Steinke J (1975) Studies of insulin release and rat pancreatic islet metabolism with diastereoisomers of D-glucose. Biochim Biophys Acta 385: 188
Ashcroft SJ, Basset JM, Randle PJ (1972) Insulin secretion mechanisms and glucose metabolism in isolated islets. Diabetes [Suppl 2] 21: 538–545
Curry DL (1974) Fructose potentiation of mannose-induced insulin secretion. Am J Physiol 226: 1073–1078
Grant AM, Christie MR, Ashcroft SJH (1980) Insulin release from human pancreatic islets in vitro. Diabetologia 19: 114–117
Gannon MC, Nuttall FQ (1987) Factors affecting interpretation of postprandial glucose and insulin areas. Diabetes Care 10: 759–763
Hollenbeck C, Reaven G (1987) Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab 64: 1169–1173
DeNobel E, Van Laar A (1978) The size of the loading dose as an important result of the oral glucose tolerance test. Diabetes 27: 42–48
Mosora F, Lefebvre B, Lacroix M (1981) Glucose oxidation in relation to the size of oral glucose loading. Metabolism 30: 1143–1149
Bratusch-Marrain PR, Waldhaus WK, Gasic S, Korn A, Nowotny P (1980) Oral glucose tolerance test: effect of different glucose load on splanchnic carbohydrate and substrate metabolism in healthy man. Metabolism 29: 289–295
Morgan LM, Wright JW, Marks V (1979) The effect of oral galactose on GIP and insulin secretion in man. Diabetologia 16: 235–239
Woods SC, Porte D (1974) Neural control of the endocrine pancreas. Physiol Rev 54: 596–619
Ganda OP, Soeldner SJ, Gleason R, Cleator IGM, Reynolds C (1979) Metabolic effects of glucose, mannose, galactose and fructose in man. J Clin Endocrinol Metab 49: 616–622
Ellwood K, Michaelis O, Hallfrischt J, O’Dorisio T, Cataland S (1983) Blood insulin, glucose, fructose and gastric inhibitory peptide levels in carbohydrate-sensitive and normal men given a sucrose or invert sugar tolerance test. J Nutr 113: 1732–1736
Crapo PA, Reaven GM, Olefski JM (1977) Post-prandial glucose and insulin responses to different complex carbohydrates. Diabetes 26: 1178–1183
Krzowski PA, Nuttfall FQ, Gannon M, Billington C, Parker S (1987) Insulin and glucose response to various starch-containing foods in type II diabetic subjects. Diabetes Care 10: 205–212
Riou JP, Normand S, Kahlfallah Y (1988) Measurement of 13 glucose in the blood arising from starch food naturally labelled, with gas chromatograph isotope ratio mass spectrometer. Starch Workshop INRA, Nantes, November 1988
Asplin CM, Hollander PM, Palmer JP (1984) How does glucose regulate the human pancreatic A cell in vivo? Diabetologia 26: 203–207
Porte Jr D, Halter JB (1981) The endocrine pancreas and diabetes mellitus. In: Williams RH (ed) Textbook of endocrinology. 6th ed. Saunders, Philadelphia, pp 716–843
Hisatoni A, Maruyama H, Orci L, Vasko M, Unger RH (1985) Andrenergically mediated intrapancreatic control of the glucagon response to glucopenia in the isolated rat pancreas. J Clin Invest 75: 420–426
Fao PP The secretion of glucagon (1972) In: Geiger SR (ed) Handbook of physiology, section 7: endocrinology, vol 1: Endocrine Pancreas. Williams and Wilkins, Baltimore pp 261–277
Grill V, Adamson U, Rundfeldt M, Anderson S (1979) Glucose memory of pancreatic B and A cells. J Clin Invest 64: 700–707
Molinari D, Angeletti G, Santeusanio F, Falomi A (1982) Blood glucose plasma insulin and glucagon response to intravenous administration of glucose in premature infants during the first week of life. J Endocrinol Invest 5: 169–171
Young JB, Landsberg L (1977) Stimulation of the sympathetic nervous system during glucose feeding. Nature 269: 615–617
Welle S, Lilavivat U, Campbell RG (1981) Thermic effect of feeding in man: increased plasma norepinephrine levels following glucose but not protein on fat consumption. Metab Clin Exp 30: 353–358
Tse TF, Clutter WE, Shah JD, Miller JP, Cryer PE (1983) Neuro-endocrine responses to glucose ingestion in man; specifically temporal relationships and quantitative aspects. J Clin Invest 72: 270–277
Defronzo RA, Thorin D, Felber JP et al. (1984) Effect of Beta and Alphadrenergic blockade on glucose induced thermogenesis in man. J Clin Invest 73: 633–639
Tse TF, Clutter WE, Shah JD, Cryer PE (1983) Mechanisms of post-prandial glucose counter regulation in man, physiologic roles of glucagon and epinephrine vis-à -vis insulin in the prevention of hypoglycemia late after glucose injection. J Clin Invest 72: 278–286
Kingston WJ, Livingston JN, Moxley-Ill RT (1986) Enhancement of insulin action after oral glucose injection. J Clin Invest 77: 1153–1162
Welle SL, Campbell RG (1983) Improved carbohydrate tolerance and stimulation of carbohydrate oxidation and lipogenesis during short-term carbohydrate overfeeding. Metabolism 32: 889–893
Acheson ICJ, Schutz T, Bessard T, Ravussin E, Jéquier E, Flatt JP (1984) Nutritional influences on lipogenesis and thermogenesis after a carbohydrate meal. Am J Physiol 246: E62–70
Landsberg L, Young JB (1980) The role of the sympatho-adrenal system in modulating energy expenditure. Clin Endocrinol Metab 13: 475–499
Bray GA (1984) Integration of energy intake and expenditure in animals and man: the autonomic and adrenal hypothesis. Clin Endocrinol Metab 13: 521–546
Katz J, McGarry JD (1984) The glucose paradox: is glucose a substrate for liver metabolism? J Clin Invest 76: 1901–1909
References
Samols E, Tyler JM, Marks V (1972) Glucagon—insulin interrelationships In Lefebvre PJ, Unger RH (eds) Glucagon: molecular physiology, clinical and therapeutic implications. Pergamon Press, Oxford
Samols E, Stagner JI, Ewart RBL, Marks V (1988) The order of islet microvascular perfusion is B-A-D in the perfused rat pancreas. J Clin Invest 82: 350–353
Reference
Torsdottir I, Alpsten M, Andersson H et al. (1989) Effect of different starchy foods in composite meals on gastric emptying rate and glucose metabolism. Hum Nutr Clin Nutr (in press)
References
Gibby OM, Hales CN (1983) Oral glucose decreases hepatic extraction of insulin. Br Med J 286: 921–923
Hampton SM, Morgan LM, Tredger JA, Cramb R, Marks V (1986) Insulin and C-peptide levels after oral and intravenous glucose. Contribution of the entero-insular axis to insulin secretion. Diabetes 35: 612–616
McIntyre N, Holdsworth CD, Turner DS (1964) New interpretation of oral glucose tolerance. Lancet 11: 20–21
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Laville, M., Picard, S., Normand, S., Riou, J.P. (1989). Insulin, Glucagon and Catecholamine Responses to the Ingestion of Various Carbohydrates. In: Dobbing, J. (eds) Dietary Starches and Sugars in Man: A Comparison. ILSI Human Nutrition Reviews. Springer, London. https://doi.org/10.1007/978-1-4471-1701-8_12
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DOI: https://doi.org/10.1007/978-1-4471-1701-8_12
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