Skip to main content

Insulin, Glucagon and Catecholamine Responses to the Ingestion of Various Carbohydrates

  • Chapter
Dietary Starches and Sugars in Man: A Comparison

Part of the book series: ILSI Human Nutrition Reviews ((ILSI HUMAN))

  • 210 Accesses

Abstract

The hormonal and metabolic events occurring during an oral glucose load have been extensively characterised in man. The use of tracers, the splanchnic hepatic balance technique and indirect calorimetry [1] have permitted the measurement of most, if not all the kinetic parameters of glucose metabolism. Despite this extensive work the mechanisms involved in the regulation of glycaemia are still the subject of debate and research. Most of the sophisticated methodology used still needs to be applied to various carbohydrate nutrients which are usually transformed inside the body into glucose before being oxidised, stored or recycled. The aim of this short review is not to provide extensive data on the glycaemic index of various carbohydrates, but to focus on the respective roles of hormones and glucose per se, and to underline some remaining methodological problems in this kind of study.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alberti KGM, Home PD, Taylor R (1987) Technique for metabolic investigation in man, Clin Endocrinol Metab 1: 773–1071

    Google Scholar 

  2. Waldhausl WK, Gasic S, Bratusch-Marrain P, Nowotny P (1983) The 75 g oral glucose tolerance test: effect on splanchnic metabolism of substrates and pancreatic hormone release in healthy man. Diabetologia 25: 484–495

    Article  Google Scholar 

  3. Ferrannini E, Bjorkman O, Reichard GA et al. (1985) The disposal of an oral glucose load in healthy subjects. A quantitative study. Diabetes 34: 580–588

    Article  PubMed  CAS  Google Scholar 

  4. Abumrad NJ, Cherrington AD, Williams PE, Lacy WW, Rabin D (1982) Absorption and disposition of a glucose load in the conscious dog. Am J Physiol 242: E398 — E406

    PubMed  CAS  Google Scholar 

  5. Kelly D, Mitrakou A, March H et al. (1988) Skeletal muscle glycolysis, oxidation and storage of an oral glucose load. J Clin Invest 81: 1563–1571

    Article  Google Scholar 

  6. Jackson RA, Rosmansa RD, Hawa MI, Sim BM, Disilvio I (1986) Impact of glucose ingestion on hepatic and peripheral glucose metabolism in man: An analysis based on simultaneous use of forearm and double isotope techniques. J Clin Endocrinol Metab 63: 541–549

    Article  PubMed  CAS  Google Scholar 

  7. Adkins BA, Myers SR, Hendrick GL, Stevenson RW, Williams PE, Cherrington AD (1987) Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J Clin Invest 79: 557–565

    Article  PubMed  CAS  Google Scholar 

  8. Rizza RA, Mandarino LI, Gerich JE (1981) Dose response characteristics for effects of insulin on production and utilisation of glucose in man. Am J Physiol 240: E630 — E639

    PubMed  CAS  Google Scholar 

  9. Gottesman I, Mandarino L, Gerich J (1984) Use of glucose uptake and glucose clearance for the evolution of insulin action in vivo. Diabetes 33: 184–191

    PubMed  CAS  Google Scholar 

  10. Jacot E, Defronzo A, Jequier E, Maeder E, Felber JP (1982) The effect of hyperglycemia, hyperinsulinemia and route of glucose administration on glucose oxidation and glucose storage. Metabolism 31: 922–990

    Article  PubMed  CAS  Google Scholar 

  11. Randle PJ, Newsholme EA, Garland PB (1964) Regulation of glucose uptake by muscle; effects of fatty acids, ketone bodies and pyruvate and of alloxan diabetes and starvation on the uptake and metabolic fats of glucose in rat heart and diaphragm muscles. Biochem J 93: 657–685

    Google Scholar 

  12. Ferrannini E, Garett EJ, Beuilacqua J, Defronzo RA (1983) Effect of fatty acids on glucose production and utilization in man. J Clin Invest 72: 1737–1747

    Article  PubMed  CAS  Google Scholar 

  13. Jequier E, Felber JP (1987) Role of fats in obesity and type II diabetes mellitus. In: Horisberger M, Bracco U (eds) Lipids in modem nutrition. Raven Press, pp 205–211

    Google Scholar 

  14. Ebiner JR, Acheson KJ, Doemer A (1979) Carbohydrate utilization in man using indirect calorimetry and mass spectometry after an oral load of 100 g naturally labelled 13C glucose. Br J Nutr 41: 419–429

    Article  PubMed  CAS  Google Scholar 

  15. Dix D, Cohen P (1980) Interpretation of the glucose tolerance test. Diabetologia 19: 488–494

    Article  PubMed  CAS  Google Scholar 

  16. Kaden M, Harding P, Field JB (1973) Effect of intraduodenal glucose administration on hepatic extraction of insulin in anesthetized dog. J Clin Invest 52: 2016–2028

    Article  PubMed  CAS  Google Scholar 

  17. Rubinstein AH, Clark JL, Melani F, Steiner D (1969) Secretion of proinsulin and C peptide by pancreatic beta cells and its circulation in blood. Nature 224: 697–699

    Article  Google Scholar 

  18. Polonsky K, Jaspan J, Pugh W et al. (1983) Metabolism of C-peptide in the dog: in vivo demonstration of the absence of hepatic extraction. J Clin Invest 72: 1114–1123

    Article  PubMed  CAS  Google Scholar 

  19. Eaton RP, Allen RC, Schade DS (1983) Hepatic removal of insulin in normal man: dose response to endogenous insulin secretion. J Clin Endocrinol Metab 56: 1294–1301

    Article  PubMed  CAS  Google Scholar 

  20. Polonsky K, Licino-Paixao J, Given BD et al. (1986) Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J Clin Invest 77: 98–105

    Article  PubMed  CAS  Google Scholar 

  21. Faber OK, Madsbad S, Kehlet M, Binder C (1978) Pancreatic beta cell secretion during oral and intravenous glucose administration. Acta Med Scand [Suppl] 624: 61–64

    Google Scholar 

  22. Elrick M, Stimmler L, Mcao C, Arai Y (1964) Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab 24: 1076–1082

    Article  PubMed  CAS  Google Scholar 

  23. McIntyre N, Holdsworth C, Turner P (1965) Intestinal factors in the context of insulin secretion. J Clin Endocrinol 25: 1317–1324

    Article  CAS  Google Scholar 

  24. Madsbad O, Kehlet M, Hilsted J, Tronier B (1983) Discrepancy between plasma C-peptide and insulin response to oral and intravenous glucose. Diabetes 32: 436–438

    Article  PubMed  CAS  Google Scholar 

  25. Pipeleers D (1987) The biosociology of pancreatic B cells. Diabetologia 30: 277–291

    Article  PubMed  CAS  Google Scholar 

  26. Trimble ER, Bruzzone R, Gjsnovci A, Renold AE (1985) Activity of the insulo-acinar axis in the isolated perfused pancreas. Endocrinology 117: 1246–1252

    Article  PubMed  CAS  Google Scholar 

  27. Curry DL, Bennett LL, Grodsky GM (1968) Dynamics of insulin secretion by the perfused pancreas. Endocrinology 83: 572–584

    Article  PubMed  CAS  Google Scholar 

  28. Jarrett RI, Keen H (1968) Oxidation of sugars, other than glucose, by isolated mammalian islets of Langerhans Metabolism 17: 155–159

    CAS  Google Scholar 

  29. MacDonald MJ, Ball DH, Patel TN, Lauris V, Steinke J (1975) Studies of insulin release and rat pancreatic islet metabolism with diastereoisomers of D-glucose. Biochim Biophys Acta 385: 188

    PubMed  CAS  Google Scholar 

  30. Ashcroft SJ, Basset JM, Randle PJ (1972) Insulin secretion mechanisms and glucose metabolism in isolated islets. Diabetes [Suppl 2] 21: 538–545

    CAS  Google Scholar 

  31. Curry DL (1974) Fructose potentiation of mannose-induced insulin secretion. Am J Physiol 226: 1073–1078

    PubMed  CAS  Google Scholar 

  32. Grant AM, Christie MR, Ashcroft SJH (1980) Insulin release from human pancreatic islets in vitro. Diabetologia 19: 114–117

    Article  PubMed  CAS  Google Scholar 

  33. Gannon MC, Nuttall FQ (1987) Factors affecting interpretation of postprandial glucose and insulin areas. Diabetes Care 10: 759–763

    Article  PubMed  CAS  Google Scholar 

  34. Hollenbeck C, Reaven G (1987) Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab 64: 1169–1173

    Article  PubMed  CAS  Google Scholar 

  35. DeNobel E, Van Laar A (1978) The size of the loading dose as an important result of the oral glucose tolerance test. Diabetes 27: 42–48

    Article  CAS  Google Scholar 

  36. Mosora F, Lefebvre B, Lacroix M (1981) Glucose oxidation in relation to the size of oral glucose loading. Metabolism 30: 1143–1149

    Article  PubMed  CAS  Google Scholar 

  37. Bratusch-Marrain PR, Waldhaus WK, Gasic S, Korn A, Nowotny P (1980) Oral glucose tolerance test: effect of different glucose load on splanchnic carbohydrate and substrate metabolism in healthy man. Metabolism 29: 289–295

    Article  PubMed  CAS  Google Scholar 

  38. Morgan LM, Wright JW, Marks V (1979) The effect of oral galactose on GIP and insulin secretion in man. Diabetologia 16: 235–239

    Article  PubMed  CAS  Google Scholar 

  39. Woods SC, Porte D (1974) Neural control of the endocrine pancreas. Physiol Rev 54: 596–619

    PubMed  CAS  Google Scholar 

  40. Ganda OP, Soeldner SJ, Gleason R, Cleator IGM, Reynolds C (1979) Metabolic effects of glucose, mannose, galactose and fructose in man. J Clin Endocrinol Metab 49: 616–622

    Article  PubMed  CAS  Google Scholar 

  41. Ellwood K, Michaelis O, Hallfrischt J, O’Dorisio T, Cataland S (1983) Blood insulin, glucose, fructose and gastric inhibitory peptide levels in carbohydrate-sensitive and normal men given a sucrose or invert sugar tolerance test. J Nutr 113: 1732–1736

    PubMed  CAS  Google Scholar 

  42. Crapo PA, Reaven GM, Olefski JM (1977) Post-prandial glucose and insulin responses to different complex carbohydrates. Diabetes 26: 1178–1183

    Article  PubMed  CAS  Google Scholar 

  43. Krzowski PA, Nuttfall FQ, Gannon M, Billington C, Parker S (1987) Insulin and glucose response to various starch-containing foods in type II diabetic subjects. Diabetes Care 10: 205–212

    Article  Google Scholar 

  44. Riou JP, Normand S, Kahlfallah Y (1988) Measurement of 13 glucose in the blood arising from starch food naturally labelled, with gas chromatograph isotope ratio mass spectrometer. Starch Workshop INRA, Nantes, November 1988

    Google Scholar 

  45. Asplin CM, Hollander PM, Palmer JP (1984) How does glucose regulate the human pancreatic A cell in vivo? Diabetologia 26: 203–207

    Article  PubMed  CAS  Google Scholar 

  46. Porte Jr D, Halter JB (1981) The endocrine pancreas and diabetes mellitus. In: Williams RH (ed) Textbook of endocrinology. 6th ed. Saunders, Philadelphia, pp 716–843

    Google Scholar 

  47. Hisatoni A, Maruyama H, Orci L, Vasko M, Unger RH (1985) Andrenergically mediated intrapancreatic control of the glucagon response to glucopenia in the isolated rat pancreas. J Clin Invest 75: 420–426

    Article  Google Scholar 

  48. Fao PP The secretion of glucagon (1972) In: Geiger SR (ed) Handbook of physiology, section 7: endocrinology, vol 1: Endocrine Pancreas. Williams and Wilkins, Baltimore pp 261–277

    Google Scholar 

  49. Grill V, Adamson U, Rundfeldt M, Anderson S (1979) Glucose memory of pancreatic B and A cells. J Clin Invest 64: 700–707

    Article  PubMed  CAS  Google Scholar 

  50. Molinari D, Angeletti G, Santeusanio F, Falomi A (1982) Blood glucose plasma insulin and glucagon response to intravenous administration of glucose in premature infants during the first week of life. J Endocrinol Invest 5: 169–171

    PubMed  CAS  Google Scholar 

  51. Young JB, Landsberg L (1977) Stimulation of the sympathetic nervous system during glucose feeding. Nature 269: 615–617

    Article  PubMed  CAS  Google Scholar 

  52. Welle S, Lilavivat U, Campbell RG (1981) Thermic effect of feeding in man: increased plasma norepinephrine levels following glucose but not protein on fat consumption. Metab Clin Exp 30: 353–358

    Article  Google Scholar 

  53. Tse TF, Clutter WE, Shah JD, Miller JP, Cryer PE (1983) Neuro-endocrine responses to glucose ingestion in man; specifically temporal relationships and quantitative aspects. J Clin Invest 72: 270–277

    Article  PubMed  CAS  Google Scholar 

  54. Defronzo RA, Thorin D, Felber JP et al. (1984) Effect of Beta and Alphadrenergic blockade on glucose induced thermogenesis in man. J Clin Invest 73: 633–639

    Article  PubMed  CAS  Google Scholar 

  55. Tse TF, Clutter WE, Shah JD, Cryer PE (1983) Mechanisms of post-prandial glucose counter regulation in man, physiologic roles of glucagon and epinephrine vis-à-vis insulin in the prevention of hypoglycemia late after glucose injection. J Clin Invest 72: 278–286

    Article  PubMed  CAS  Google Scholar 

  56. Kingston WJ, Livingston JN, Moxley-Ill RT (1986) Enhancement of insulin action after oral glucose injection. J Clin Invest 77: 1153–1162

    Article  PubMed  CAS  Google Scholar 

  57. Welle SL, Campbell RG (1983) Improved carbohydrate tolerance and stimulation of carbohydrate oxidation and lipogenesis during short-term carbohydrate overfeeding. Metabolism 32: 889–893

    Article  PubMed  CAS  Google Scholar 

  58. Acheson ICJ, Schutz T, Bessard T, Ravussin E, Jéquier E, Flatt JP (1984) Nutritional influences on lipogenesis and thermogenesis after a carbohydrate meal. Am J Physiol 246: E62–70

    PubMed  CAS  Google Scholar 

  59. Landsberg L, Young JB (1980) The role of the sympatho-adrenal system in modulating energy expenditure. Clin Endocrinol Metab 13: 475–499

    Article  Google Scholar 

  60. Bray GA (1984) Integration of energy intake and expenditure in animals and man: the autonomic and adrenal hypothesis. Clin Endocrinol Metab 13: 521–546

    Article  PubMed  CAS  Google Scholar 

  61. Katz J, McGarry JD (1984) The glucose paradox: is glucose a substrate for liver metabolism? J Clin Invest 76: 1901–1909

    Article  Google Scholar 

References

  1. Samols E, Tyler JM, Marks V (1972) Glucagon—insulin interrelationships In Lefebvre PJ, Unger RH (eds) Glucagon: molecular physiology, clinical and therapeutic implications. Pergamon Press, Oxford

    Google Scholar 

  2. Samols E, Stagner JI, Ewart RBL, Marks V (1988) The order of islet microvascular perfusion is B-A-D in the perfused rat pancreas. J Clin Invest 82: 350–353

    Article  PubMed  CAS  Google Scholar 

Reference

  1. Torsdottir I, Alpsten M, Andersson H et al. (1989) Effect of different starchy foods in composite meals on gastric emptying rate and glucose metabolism. Hum Nutr Clin Nutr (in press)

    Google Scholar 

References

  1. Gibby OM, Hales CN (1983) Oral glucose decreases hepatic extraction of insulin. Br Med J 286: 921–923

    Article  CAS  Google Scholar 

  2. Hampton SM, Morgan LM, Tredger JA, Cramb R, Marks V (1986) Insulin and C-peptide levels after oral and intravenous glucose. Contribution of the entero-insular axis to insulin secretion. Diabetes 35: 612–616

    Article  PubMed  CAS  Google Scholar 

  3. McIntyre N, Holdsworth CD, Turner DS (1964) New interpretation of oral glucose tolerance. Lancet 11: 20–21

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Laville, M., Picard, S., Normand, S., Riou, J.P. (1989). Insulin, Glucagon and Catecholamine Responses to the Ingestion of Various Carbohydrates. In: Dobbing, J. (eds) Dietary Starches and Sugars in Man: A Comparison. ILSI Human Nutrition Reviews. Springer, London. https://doi.org/10.1007/978-1-4471-1701-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-1701-8_12

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1703-2

  • Online ISBN: 978-1-4471-1701-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics