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Advances in Biodegradable Ocular Drug Delivery Systems

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Drug Product Development for the Back of the Eye

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 2))

Abstract

The limitations of existing medical therapies for ocular disorders include low drug bioavailability, nonspecificity, side effects, and poor treatment adherence to therapy. These limitations may be overcome through the use of sustained-release intraocular drug delivery systems. Critical to the development of such systems has been the introduction of biocompatible polymers (biodegradable and nonbiodegradable) that allow for drug release kinetics to be tailored for specific drugs and ocular diseases. Drug delivery systems composed of biodegradable polymers, such as polylactic-co-glycolic acid, appear to be particularly well suited for such applications. This review examines the characteristics of these polymers for medical applications, as well as the pharmacological properties, safety, and clinical effectiveness of biodegradable drug implants for the treatment of sight-threatening ocular diseases.

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Abbreviations

EVA:

Ethylene vinyl acetate

HEMA:

Hydroxyethylmethacrylate

HPC:

Hydroxypropyl cellulose

HPMC:

Hydroxypropyl methylcellulose

PAH:

Polyanhydride

PBMA:

Polybutyl methacrylate

PCL:

Poly(-ε-caprolactone)

PCL-PEG:

Poly(ε-caprolactone)-poly(ethylene glycol)

PDLLA:

d,l-poly(lactic acid)

PDO:

Polydioxane

PDS:

Poly-p-dioxane

PETP:

Polyethylene terephthalate

PGA:

Poly(glycolic acid)

PGLC:

Poly(glycolide-co-lactide-co-caprolactone)

PHEMA:

Poly(2-hydroxyethylmethacrylate)

PLA:

Poly(lactic acid)

PLGA:

Poly(lactic-co-glycolic acid)

PLLA:

Poly(l-lactic acid)

PLTMC:

Poly(l-lactide-co-1,3-trimethylene carbonate)

PMM:

Polymethylidene malonate

POE:

Poly(ortho ester)

PPF:

Polypropylene fumarate

PVA:

Polyvinyl alcohol

PVP:

Poly(N-vinyl pyrrolidone)

TMC:

Trimethylene carbonate

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Authors and Affiliations

  1. Allergan, Inc., Irvine, CA, USA

    Susan S. Lee MS, Patrick Hughes PhD & Michael R. Robinson MD

  2. Triton Biomedical, Inc., Laguna Beach, CA, USA

    Aron D. Ross PhD

Authors
  1. Susan S. Lee MS
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  2. Patrick Hughes PhD
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  3. Aron D. Ross PhD
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  4. Michael R. Robinson MD
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Correspondence to Susan S. Lee MS .

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Editors and Affiliations

  1. School of Pharmacy, University of Colorado Denver, East 17th Avenue 12631, Aurora, 80045, Colorado, USA

    Uday B. Kompella

  2. School of Medicine, Emory University, Clifton Road NE., 1365, Atlanta, 30322, Georgia, USA

    Henry F. Edelhauser

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© 2011 American Association of Pharmaceutical Scientists

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Lee, S.S., Hughes, P., Ross, A.D., Robinson, M.R. (2011). Advances in Biodegradable Ocular Drug Delivery Systems. In: Kompella, U., Edelhauser, H. (eds) Drug Product Development for the Back of the Eye. AAPS Advances in the Pharmaceutical Sciences Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9920-7_9

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