Abstract
Organophosphorous pesticides (OPs) are widely used in agriculture due to their high effectiveness and low toxicity for pest control and protecting crops and seeds [1, 2]. Their residuals in crops, livestock, and poultry products are clearly dangerous to human health. The related clinical signs include negative effects on the visual system, sensory function, cognitive function, and nervous system [3, 4]. Specifically, exposure to OPs has been shown to cause headache, dizziness, profuse sweating, blurred vision, nausea, vomiting, reduced heartbeat, diarrhea, loss of coordination, slow and weak breathing, fever, coma, and even death [5]. The toxicity of OPs mainly arises from their irreversible inhibition on acetylcholinesterase (AChE), which is essential for the central nervous system to function, often causing respiratory paralysis and death [6]. Because of the high toxicities, rapid detection of these agents in the environment, public places, or workplaces and the monitoring of individual exposures to OPs have become increasingly important for homeland security and health protection [7].
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References
Valdez Salas, B., Garcia Duran, E.I., Wiener, M.S.: Impact of pesticides use on human health in Mexico: a review. Rev. Environ. Health 15, 399–412 (2000)
Van der Hoff, G.R., Van Zoonen, P.: Trace analysis of pesticides by gas chromatography. J. Chromatogr. A 843, 301–322 (1999)
Nuñez, O., Moyano, E., Galceran, M.T.: LC-MS/MS analysis of organic toxics in food. Trac Trends Anal. Chem. 24, 683–703 (2005)
Rial-Otero, R., Gaspar, E.M., Capelo, J.L., et al.: Chromatographic-based methods for pesticide determination in honey: an overview. Talanta 71, 503–514 (2007)
Bhand, S., Surugiu, I., Danielsson, B., et al.: Immuno-arrays for multianalyte analysis of chlorotriazines. Talanta 65, 331–336 (2005)
Kumar, M.A., Chouhan, R.S., Thakur, M.S., et al.: Automated flow enzyme-linked immunosorbent assay (ELISA) system for analysis of methyl parathion. Anal. Chim. Acta 560, 30–34 (2006)
Marty, J.L., Garcia, D., Rouillon, R.: Biosensor: potential in pesticide detection. Trac Trends Anal. Chem. 14, 329–333 (1995)
Guilbault, G.G., Pravda, M., Kreuzer, M.: Biosensors – 42 years and counting. Anal. Lett. 37, 14481–14496 (2004)
Mulchandani, P., Mulchandani, A., Chen, W., et al.: Biosensor for direct determination of organophosphate nerve agents. 1. Potentiometric enzyme electrode. Biosens. Bioelectron. 14, 77–85 (1999)
Gogol, E.V., Evtugyn, G.A., Marty, J.L., et al.: Amperometric biosensors based on Nafion coated screen-printed electrodes for the determination of cholinesterase inhibitors. Talanta 53, 379–389 (2000)
Anh, T.M., Dzyadevych, S.V., Van, M.C., et al.: Conductometric tyrosinase biosensor for the detection of diuron, atrazine and its main metabolites. Talanta 63, 365–370 (2004)
Barr, D.B., Thomas, K., Curwin, B., et al.: Biomonitoring of exposure in farmworker studies. Environ. Health Perspect. 114, 936–942 (2006)
Laschi, S., Ogónczyk, D., Palchetti, I., et al.: Evaluation of pesticide-induced acetylcholinesterase inhibition by means of disposable carbon-modified electrochemical biosensors. Enzyme Microb. Technol. 40, 485–489 (2007)
Bakker, E., Qin, Y.: Electrochemical sensors. Anal. Chem. 78, 3965–3984 (2006)
Khayyami, M., Pita, M.T.P., Larsson, P.O., et al.: Development of an amperometric biosensor based on acetylcholine esterase covalently bound to a new support material. Talanta 45, 557–563 (1998)
Mitchell, K.M.: Acetylcholine and choline amperometric enzyme sensors characterized in vitro and in vivo. Anal. Chem. 76, 1098–1106 (2004)
Joshi, K.A., Tang, J., Mulchandani, A., et al.: A disposable biosensor for organophosphorus nerve agents based on carbon nanotubes modified thick film strip electrode. Electroanalysis 17, 54–58 (2005)
Liu, G.D., Riechers, S.L., Lin, Y.H., et al.: Sensitive electrochemical detection of enzymatically generated thiocholine at carbon nanotube modified glassy carbon electrode. Electrochem. Commun. 7, 1163–1169 (2005)
Liu, G.D., Lin, Y.H.: Biosensor based on self-assembling acetylcholinesterase on carbon nanotubes for flow injection/amperometric detection of organophosphate pesticides and nerve agents. Anal. Chem. 78, 835–843 (2006)
Du, D., Ju, H.X., Cai, J., et al.: An amperometric acetylthiocholine sensor based on immobilization of acetylcholinesterase on a multiwall carbon nanotube–cross-linked chitosan composite. Anal. Bioanal. Chem. 387, 1059–1065 (2007)
Du, D., Ju, H.X., Zhang, A.D., et al.: Amperometric detection of triazophos pesticide using acetylcholinesterase biosensor based on multiwall carbon nanotube–chitosan matrix. Sens. Actuators B Chem. 127, 531–535 (2007)
Du, D., Cai, J., Zhang, A.D., et al.: Rapid determination of triazophos using acetylcholinesterase biosensor based on sol-gel interface assembling multiwall carbon nanotubes. J. Appl. Electrochem. 37, 893–898 (2007)
Lin, T.L., Huang, K.T., Liu, C.Y.: Determination of organophosphorus pesticides by a novel biosensor based on localized surface plasmon resonance. Biosens. Bioelectron. 22, 513–518 (2006)
Du, D., Ding, J.W., Zhang, A.D., et al.: Electrochemical thiocholine inhibition sensor based on biocatalytic growth of Au nanoparticles using chitosan as template. Sens. Actuators B Chem. 127, 317–322 (2007)
Du, D., Chen, S.Z., Zhang, A.D., et al.: Immobilization of acetylcholinesterase on gold nanoparticles embedded in sol-gel film for amperometric detection of organophosphorus insecticide. Biosens. Bioelectron. 23, 130–134 (2007)
Du, D., Chen, S.Z., Chen, X., et al.: Development of acetylcholinesterase biosensor based on CdTe quantum dots/gold nanoparticles modified chitosan microspheres interface. Biosens. Bioelectron. 24, 475–479 (2008)
Doretti, L., Ferrara, D., Lora, S., et al.: Acetylcholine biosensor involving entrapment of acetylcholinesterase and poly(ethylene glycol)-modified choline oxidase in a poly(vinyl alcohol) cryogel membrane. Enzyme Microb. Technol. 27, 279–285 (2000)
Kok, F.N., Bozoglu, F., Hasirci, V.: Construction of an AChE-ChO biosensor for aldicarb determination. Biosens. Bioelectron. 17, 531–539 (2002)
Abou-Donia, M.B.: Organophosphorus ester-induced chronic neurotoxicity. Arch. Environ. Health 5, 484–497 (2003)
Suprun, E., Evtugyn, G., Budnikov, H., et al.: Acetylcholinesterase sensor based on screen-printed carbon electrode modified with prussian blue. Anal. Bioanal. Chem. 383, 597–604 (2005)
Chen, Q., Kobayashi, Y., Anzai, J., et al.: Avidin-biotin system-based enzyme multilayer membranes for biosensor applications: optimization of loading of choline esterase and choline oxidase in the bienzyme membrane for acetylcholine biosensors. Electroanalysis l0, 94–97 (1998)
Neufeld, T., Eshkenazi, I., Rishpon, J., et al.: A micro flow injection electrochemical biosensor for organophosphorus pesticides. Biosens. Bioelectron. 15, 323–329 (2000)
Wang, J., Liu, G.D., Lin, Y.H.: Amperometric choline biosensor fabricated through electrostatic assembly of bienzyme/polyelectrolyte hybrid layers on carbon nanotubes. Analyst 131, 477–483 (2006)
Kok, F.N., Hasirci, V.: Determination of binary pesticide mixtures by an acetylcholinesterase–choline oxidase biosensor. Biosens. Bioelectron. 19, 661–665 (2004)
Huang, X., Du, D., Zhang, A.D., et al.: A gold nanoparticle labeling strategy for the sensitive kinetic assay of the carbamate–acetylcholinesterase interaction by surface plasmon resonance. Talanta 78, 1036–1042 (2009)
Valdés-Ramírez, G., Cortina, M., Marty, J., et al.: Acetylcholinesterase-based biosensors for quantification of carbofuran, carbaryl, methylparaoxon, and dichlorvos in 5% acetonitrile. Anal. Bioanal. Chem. 392, 699–707 (2008)
Shulga, O., Kirchhoff, J.R.: An acetylcholinesterase enzyme electrode stabilized by an electrodeposited gold nanoparticle layer. Electrochem. Commun. 9, 935–940 (2007)
Matsuura, H., Sato, Y., Niwa, O., et al.: Surface electrochemical enzyme immunoassay for the highly sensitive measurement of B-type natriureric peptide. Sens. Actuators B Chem. 108, 603–607 (2005)
Du, D., Chen, W.J., Li, H.B., et al.: Development of acetylcholinesterase biosensor based on CdTe quantum dots modified cysteamine self-assembled monolayers. J. Electroanal. Chem. 623, 81–85 (2008)
Zejli, H., Naranjo-Rodriguez, I., Marty, J.L., et al.: Alumina sol–gel/sonogel-carbon electrode based on acetylcholinesterase for detection of organophosphorus pesticides. Talanta 77, 217–221 (2008)
Arduini, F., Ricci, F., Tuta, C.S., et al.: Detection of carbamic and organophosphorous pesticides in water samples using cholinesterase biosensor based on Prussian blue modified screen printed electrode. Anal. Chim. Acta 580, 155–162 (2006)
Snejdarkova, M., Svobodova, L., Hianik, T., et al.: Acetylcholinesterase sensors based on gold electrodes modified with dendrimer and polyaniline: a comparative research. Anal. Chim. Acta 514, 79–88 (2004)
Du, D., Chen, S.Z., Song, D.D., et al.: Comparison of drug sensitivity using acetylcholinesterase biosensor based on nanoparticles–chitosan sol–gel composite. J. Electroanal. Chem. 611, 60–66 (2007)
Du, D., Ding, J.W., Cai, J., et al.: Determination of carbaryl pesticide using amperometric acetylcholinesterase sensor formed by electrochemically deposited chitosan. Colloid Surf. B 58, 145–150 (2007)
Schulze, H., Vorlová, S., Schmid, R.D., et al.: Design of acetylcholinesterases for biosensor applications. Biosens. Bioelectron. 18, 201–209 (2003)
Luque de Castro, M.D., Herrera, M.C.: Enzyme inhibition-based biosensors and biosensing systems: questionable analytical devices. Biosens. Bioelectron. 18, 279–294 (2003)
Andreescu, D., Andreescu, S., Sadik, O.A.: New materials for biosensors, biochips and molecular bioelectronics. In: Gorton, L. (ed.) Biosensors and Modern Biospecific Analytical Techniques, pp. 285–329. Elsevier, Amsterdam (2005)
Andreescu, S., Magearu, V., Marty, J.L., et al.: Immobilization of enzymes on screen-printed sensors via a histidine tail. Application to the detection of pesticides using modified cholinesterase. Anal. Lett. 34, 429–540 (2001)
Andreescu, S., Avramescu, A., Marty, J.L., et al.: Detection of organophosphorus insecticides with immobilized acetylcholinesterase − comparative study of two enzyme sensors. Anal. Bioanal. Chem. 374, 39–45 (2002)
Mulchandani, A., Mulchandani, P., Chen, W.: Enzyme biosensor for determination of organophosphates. Field Anal. Chem. Technol. 6, 363–369 (1998)
Mulchandani, A., Mulchandani, P., Chen, W., et al.: Biosensor for direct determination of organophosphate nerve agents using recombinant Escherichia coli with surface-expressed organophosphorus hydrolase. 1. Potentiometric microbial electrode. Anal. Chem. 70, 4140–4145 (1998)
Constantine, C.A., Mello, S.V., Leblanc, R.M., et al.: Layer-by-layer self-assembled chitosan/poly(thiophene-3-acetic acid) and organophosphorus hydrolase multilayers. J. Am. Chem. Soc. 125, 1805–1809 (2003)
Lee, Y., Stanish, I., Singh, S.A., et al.: Sustained enzyme activity of organophosphorus hydrolase in polymer encased multilayer assemblies. Langmuir 19, 1330–1336 (2003)
La Rosa, C., Pariente, F., Lorenzo, E., et al.: Determination of organophosphorus and carbamic pesticides with an acetylcholinesterase amperometric biosensor using 4-aminophenyl acetate as substrate. Anal. Chim. Acta 295, 273–282 (1994)
Kumaran, S., Tranh-Minh, C.: Determination of organophosphorus and carbamate insecticides by flow injection analysis. Anal. Biochem. 200, 187–194 (1992)
Hobel, W., Polster, J., Fresenius, J.: Fiber optic biosensor for pesticides based on acetylcholine esterase. Anal. Chem. 343, 101–102 (1992)
Mulchandani, A., Mulchandani, P., Chen, W.: Amperometric thick-film strip electrodes for monitoring organophosphate nerve agents based on immobilized organophosphorus hydrolase. Anal. Chem. 71, 2246–2249 (1999)
Dave, K.I., Miller, C.E., Wild, J.R.: Characterization of organophosphorus hydrolases and the genetic manipulation of the triesterase from Pseudomonas diminuta. Chem. Biol. Interact. 87, 55–68 (1993)
Deo, R.P., Wang, J., Block, I., et al.: Determination of organophosphate pesticides at a carbon nanotube/organophosphorus hydrolase electrochemical biosensor. Anal. Chim. Acta 530, 185–189 (2005)
Benhabib, K., Town, R.M., van Leeuwen, H.P.: Dynamic speciation analysis of atrazine in aqueous latex nanoparticle dispersions using solid phase microextraction (SPME). Langmuir 25, 3381–3386 (2009)
Barry, R.C., Lin, Y.H., Wang, J.: Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures. J. Expo. Anal. Environ. Epidemiol. 19, 1–18 (2009)
Garrido, E.M., Lima, J.L.F.C., Oliveira Brett, A.M., et al.: Electrochemical oxidation of propanil and related N-substituted amides. Anal. Chim. Acta 434, 35–41 (2001)
Antiochia, R., Gorton, L.: Development of a carbon nanotube paste electrode osmium polymer-mediated biosensor for determination of glucose in alcoholic beverages. Biosens. Bioelectron. 22, 2611–2617 (2007)
Du, D., Wang, M.H., Zhang, A.D., et al.: Application of multiwalled carbon nanotubes for solid-phase extraction of organophosphate pesticide. Electrochem. Commun. 10, 85–89 (2008)
Kandimalla, V.B., Ju, H.X.: Binding of acetylcholinesterase to multiwall carbon nanotube-cross-linked chitosan composite for flow-injection amperometric detection of an organophosphorous insecticide. Chem. Eur. J. 12, 1074–1080 (2006)
Sun, W., Qin, P., Zhao, R., et al.: Direct electrochemistry and electrocatalysis of hemoglobin on gold nanoparticle decorated carbon ionic liquid electrode. Talanta 80, 2177–2181 (2010)
Ding, C.F., Li, H., Hu, K.C., et al.: Electrochemical immunoassay of hepatitis B surface antigen by the amplification of gold nanoparticles based on the nanoporous gold electrode. Talanta 80, 1385–1391 (2010)
Klein, D.L., Roth, R., Lim, A.K.L., et al.: A single-electron transistor made from a cadmium selenide nanocrystal. Nature 389, 699–701 (1997); Alivisatos, A.P.: Semiconductor clusters, nanocrystals, and quantum dots. Science 271, 933–937 (1996); Niemeyer, C.M.: Nanoparticles, proteins, and nucleic acids: biotechnology meets materials science. Angew. Chem. Int. Ed. 40, 4128–4158 (2001)
Kim, T.W., Lee, D.U., Yoon, Y.S.: Microstructural, dectrical and optical properties of SnO2 nanocrystalline thin films grown on InP(100)substrates for applications as gas sensor devices. J. Appl. Phys. 88, 3759–3761 (2000)
Bruchez, M., Moronne, M., Gin, P., et al.: Semiconductor nanocrystals as fluorescent biological labels. Science 281, 2013–2015 (1998); Chan, W.C.W., Nie, S.: Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281, 2016–2018 (1998); Willner, I., Patolsky, F., Wasserman, J.: Photoelectrochemistry with controlled DNA-cross-linked CdS nanoparticle arrays. Angew. Chem. Int. Ed. 40, 1861–1864 (2001)
Tessler, N., Medvedev, V., Banin, U., et al.: Efficient near-infrared polymer nanocrystal light-emitting diodes. Science 295, 1506–1508 (2002)
Pavesi, L., Negro, L.D., Priolo, F., et al.: Optical gain in silicon nanocrystals. Nature 408, 440–444 (2000); Malko, A.V., Mikhailovsky, A.A., Klimov, V.I., et al.: From amplified spontaneous emission to microring lasing using nanocrystal quantum dot solids. Appl. Phys. Lett. 81, 1303–1305 (2002)
Pardo-Yissar, V., Katz, E., Willner, I., et al.: Coupling of the acetylcholine esterase reaction and the photochemical process of CdS nanoparticles. J. Am. Chem. Soc. 125, 622–623 (2003)
Liu, G.D., Wang, J., Lin, Y., et al.: Nanovehicles based bioassay labels. Electroanalysis 19, 777–785 (2007)
Liu, G.D., Lin, Y.Y., Wang, J., et al.: Disposable electrochemical immunosensor diagnosis device based on nanoparticle probe and immunochromatographic strip. Anal. Chem. 79, 7644–7653 (2007)
Bart, J.C., Judd, L.L., Kusterbeck, A.W., et al.: Application of a portable immunosensor to detect the explosives TNT and RDX in groundwater samples. Environ. Sci. Technol. 31, 1505–1511 (1997)
Onnerfjord, P., Eremin, S.A., Marko-Varga, G., et al.: High sample throughput flow immunoassay utilising restricted access columns for the separation of bound and free label. J. Chromatogr. A 800, 219–230 (1998)
Wang, H., Wang, J., Lin, Y.H., et al.: Magnetic electrochemical immunoassays with quantum dot labels for detection of phosphorylated acetylcholinesterase in plasma. Anal. Chem. 80, 8477–8484 (2008)
Liu, G.D., Wang, J., Lin, Y.H., et al.: Nanoparticle-based electrochemical immunosensor for the detection of phosphorylated acetylcholinesterase: an exposure biomarker of organophosphate pesticides and nerve agents. Chem. Eur. J. 14, 9951–9959 (2008)
Schopfer, L.M., Voelker, T., Lockridge, O., et al.: Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem. Res. Toxicol. 18, 747–754 (2005)
Bajgar, J., Kuca, K., Fusek, J., et al.: Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents. Curr. Drug Metab. 7, 803–809 (2007)
Jun, D., Bajgar, J., Kuca, K., et al.: Monitoring of blood cholinesterase activity in workers exposed to nerve agents. In: Handbook of Toxicology of Chemical Warfare Agents, Chapter 56 (2009)
Holmstedt, B.: Pharmacology of organophosphoruscholinesterase inhibitors. Pharmacol. Rev. 11, 567–688 (1959)
Lotti, M.: Cholinesterase inhibition: complexities in interpretation. Clin. Chem. 41, 1814–1818 (1995)
Saboori, A.M., Newcombe, D.S.: Human monocyte carboxylesterase. Purification and kinetics. J. Biol. Chem. 265, 19792–19799 (1990)
Wilson, B.W., Padilla, S., Spies, R., et al.: Factors in standardizing automated cholinesterase assays. J. Toxicol. Environ. Health 48, 187–195 (1996)
Gundel, J., Angerer, J.: High-performance liquid chromatographic method with fluorescence detection for the determination of 3-hydroxybenzo[a]pyrene and 3-hydroxybenz[a]anthracene in the urine of polycyclic aromatic hydrocarbon-exposed workers. J. Chromatogr. B 738, 47–55 (2000)
Sexton, K., Adgate, J.L., Ashley, D.L., et al.: Using biologic markers in blood to assess exposure to multiple environmental chemicals for inner-city children 3–6 years of age. Environ. Health Perspect. 114, 453–459 (2006)
Hernandez, F., Sancho, J.V., Pozo, O.J.: Critical review of the application of liquid chromatography/mass spectrometry to the determination of pesticide residues in biological samples. Anal. Bioanal. Chem. 382, 934–946 (2005)
Lacorte, S., Barcelo, D.: Validation of an automated precolumn exchange system (prospekt) coupled to liquid chromatography with diode-array detection-application to the determination of pesticides in natural waters. Anal. Chim. Acta 296, 223–234 (1994)
Lacorte, S., Barcelo, D.: Rapid degradation of fenitrothion in estuarine waters. Environ. Sci. Technol. 28, 1159–1163 (1994)
Knopper, L.D., Trudeau, S., Mineau, P., et al.: Using dried blood spots stored on filter paper to measure cholinesterase activity in wild avian species. Biomarkers 12, 145–154 (2007)
Kousba, A.A., Poet, T.S., Timchalk, C.: Characterization of the in vitro kinetic interaction of chlorpyrifos-oxon with rat salivary cholinesterase: a potential biomonitoring matrix. Toxicology 188, 219–232 (2003)
Henn, B.C., McMaster, S., Padilla, S.: Measuring cholinesterase activity in human saliva. J. Toxicol. Environ. Health A 69, 1805–1818 (2006)
Timchalk, C., Campbell, J.A., Kousba, A.A., et al.: Development of a non-invasive biomonitoring approach to determine exposure to the organophosphorus insecticide chlorpyrifos in rat saliva. Toxicol. Appl. Pharmacol. 219, 217–225 (2007)
Gorun, V., Proinov, I., Barzu, O., et al.: Modified Ellman procedure for assay of cholinesterase in crude enzymatic preparations. Anal. Biochem. 86, 324–326 (1978)
George, K.M., Schule, T., Thompson, C.M., et al.: Differentiation between acetylcholinesterase and the organophosphate-inhibited form using antibodies and the correlation of antibody recognition with reactivation mechanism and rate. J. Biol. Chem. 278, 45512–45518 (2003)
Vamvakaki, V., Fournier, D., Chaniotakis, N.A.: Fluorescence detection of enzymatic activity within a liposome based nano-biosensor. Biosens. Bioelectron. 21, 384–388 (2005)
Maeda, H., Matsuno, H., Itoh, N., et al.: 2,4-Dinitrobenzenesulfonyl fluoresceins as fluorescent alternatives to Ellman’s reagent in thiol-quantification enzyme assays. Angew. Chem. Int. Ed. 44, 2922–2925 (2005)
Sabelle, S., Renard, P.Y., Mioskowski, C., et al.: Design and synthesis of chemiluminescent probes for the detection of cholinesterase activity. J. Am. Chem. Soc. 124, 4874–4880 (2002)
Godoy, S., Leca-Bouvier, B., Girard-Egrot, A.P., et al.: Electrochemiluminescent detection of acetylcholine using acetylcholinesterase immobilized in a biomimetic Langmuir–Blodgett nanostructure. Sens. Actuators B Chem. 107, 82–87 (2005)
Shen, Z.X., Go, E.P., Siuzdak, G., et al.: A mass spectrometry plate reader: monitoring enzyme activity and inhibition with a desorption/ionization on silicon (DIOS) platform. Chembiochem 5, 921–927 (2004)
Wang, J., Lin, Y.: Online organicphase enzyme detector. Anal. Chim. Acta 271, 53–58 (1993)
Mizutani, F., Tsuda, K.: Amperometric determination of cholinesterase with use of an immobilized enzyme electrode. Anal. Chim. Acta 139, 359–362 (1982)
Matsuura, H., Sato, Y., Mizutani, F., et al.: Rapid and highly-sensitive determination of acetylcholinesterase activity based on the potential-dependent adsorption of thiocholine on silver electrodes. Sens. Actuators B Chem. 91, 148–151 (2003)
Joshi, K.A., Prouza, M., Mulchandani, A., et al.: V-type nerve agent detection using a carbon nanotube-based amperometric enzyme electrode. Anal. Chem. 78, 331–336 (2006)
Chen, S.H., Yuan, R., Li, X.L., et al.: Amperometric third-generation hydrogen peroxide biosensor based on the immobilization of hemoglobin on multiwall carbon nanotubes and gold colloidal nanoparticles. Biosens. Bioelectron. 22, 1268–1274 (2007)
Ciucu, A.A., Negulescu, C., Baldwin, R.P.: Detection of pesticides using an amperometric biosensor based on ferophthalocyanine chemically modified carbon paste electrode and immobilized bienzymatic system. Biosens. Bioelectron. 18, 303–310 (2003)
Wang, J.: Nanomaterial-based amplified transduction of biomolecular interactions. Small 1, 1036–1043 (2005); Wang, J., Musameh, M., Lin, Y.: Solubilization of carbon nanotubes by Nafion toward the preparation of amperometric biosensors. J. Am. Chem. Soc. 125, 2408–2409 (2003)
Lin, Y., Yantasee, W., Wang, J.: Carbon nanotubes (CNTs) for the development of electrochemical biosensors. Frontiers Biosci. 10, 492–505 (2005); Lin, Y., Lu, F., Ren, Z., et al.: Glucose biosensors based on carbon nanotube nanoelectrode ensembles. Nano Lett. 4, 191–195 (2004)
Wang, J., Timchalk, C., Lin, Y.H.: Carbon nanotube-based electrochemical sensor for assay of salivary cholinesterase enzyme activity: an exposure biomarker of organophosphate pesticides and nerve agents. Environ. Sci. Technol. 42, 2688–2693 (2008)
Jun, D., Bajgar, J., Kassa, J., et al.: Monitoring of blood cholinesterase activity in workers exposed to nerve agents. In: Handbook of Toxicology of Chemical Warfare Agents, Chapter 58, pp. 877–886 (2009)
Pohanka, M., Jun, D., Kuca, K.: Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators. Talanta 77, 451–454 (2008)
Oha, K.A., Parka, N.J., Jung, Y.S., et al.: Reactivation of DFP- and paraoxon-inhibited acetylcholinesterases by pyridinium oximes. Chem. Biol. Interact. 175, 365–367 (2008)
Du, D., Huang, X., Zhang, A.D., et al.: Comparison of pesticide sensitivity by electrochemical test based on acetylcholinesterase biosensor. Biosens. Bioelectron. 23, 285–289 (2007)
Jun, D., Musilova, L., Bajgar, J., et al.: Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro. Chem. Biol. Interact. 175, 421–424 (2008)
De Jong, L.P., Van Dijk, C.: Formation of soman (1,2,2-trimethylpropyl methylphosphonofluoridate) via fluoride-induced reactivation of soman-inhibited aliesterase in rat plasma. Biochem. Pharmacol. 33, 663–669 (1984)
Polhuijs, M., Langenberg, J.P., Benschop, H.P.: Organophosphorous anticholinesterases:application to alleged sarin victims of Japanese terrorists. Toxicol. Appl. Pharmacol. 146, 156–161 (1997)
Noort, D., Benschop, H.P., de Jong, L.P.A.: Methods for retrospective detection of exposure to toxic scheduled chemicals: an overview. Voj. Zdrav. Listy 70, 14–17 (2001)
Noort, D., Benschop, H.P., Black, R.M.: Biomonitoring of exposure to chemical warfare agents: a review. Toxicol. Appl. Pharmacol. 184, 116–126 (2002)
Du, D., Wang, J., Lin, Y., et al.: Biomonitoring of organophosphorus agent exposure by reactivation of cholinesterase enzyme based on carbon nanotube-enhanced flow-injection amperometric detection. Anal. Chem. 81, 9314–9320 (2009)
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Ju, H., Zhang, X., Wang, J. (2011). Nanostructured Biosensing for Detection of Insecticides. In: NanoBiosensing. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9622-0_13
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