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Toxicity of Metallic Nanoparticles in Microorganisms- a Review

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Book cover Atmospheric and Biological Environmental Monitoring

Abstract

Recent advances in the synthesis and development of nanoparticles (NPs) for wide applications has lead to a serious threat to both human and environmental health. NPs are highly reactive and catalytic in nature compared to their ions or bulk counterparts and thus applicable in various fields including drug delivery, electronics, optics, and therapeutics. Due to these applications, many varieties of NPs in massive amounts are being industrially produced. These NPs are discharged in to the environment and thus providing a path to enter into food chain via microorganisms and eventually disturbs the ecological balance. The NPs exhibit toxicity to living organisms mainly because of their small size (>100 nm), large surface-to-volume ratio and highly reactive facets. The microorganisms including bacteria present in the natural ecosystem are the primary targets that get exposed to NPs. Before these NPs enter into the food chain, it is imperative to evaluate the toxicity associated with NPs in microorganisms. The most convenient and rapid way is to perform toxicity analysis using microorganisms such as bacteria. Toxicity of nanomaterials using microorganisms such as E.coli, Pseudomonas, Bacillus as models for prokaryotes gives an insight into the toxic impacts of NPs. Toxicities associated with NPs in microorganisms is mainly related to their nano-size that cause membrane disorganization, generation of reactive oxygen species (ROS) and in some ases, oxidative DNA damage. In this review article we describe the toxicity of various nanoparticles in bacteria and provide a rationale for assessing nanotoxicity and discuss the current status on toxicity impacts on microorganisms.

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  1. College of Life Sciences and Biotechnology, Korea University, Anam-dong, Seongbuk-Gu, Seoul 136-701, South Korea

    Javed H. Niazi & Man Bock Gu

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  1. Javed H. Niazi
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  1. Department of Environmental Science and Engineering, Gwangju Institute of Science and Technology (GIST), 261 Cheomdan-gwagiro Bug-gu, Gwangju 500-712, Republic of Korea

    Young J. Kim

  2. Institute of Environmental Physics, University of Heidelberg, Im Neuenheimer Feld 229, D-69120 Heidelberg, Germany

    Ulrich Platt

  3. College of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea

    Man Bock Gu

  4. Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Midorigaoka, 1-8-31, Ikeda, Osaka 563-8577, Japan

    Hitoshi Iwahashi

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Niazi, J.H., Gu, M.B. (2009). Toxicity of Metallic Nanoparticles in Microorganisms- a Review. In: Kim, Y.J., Platt, U., Gu, M.B., Iwahashi, H. (eds) Atmospheric and Biological Environmental Monitoring. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9674-7_12

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