Abstract
Data on the release advantages of a liposomal formulation incorporating a doxorubicin–PAMAM G4 complex in comparison to a liposomal doxorubicin are presented. The liposomes incorporating either doxorubicin-PAMAM complex, or doxorubicin as free drug, were composed of Egg-phosphatidylcholine (EPC): Stearylamine (SA) at a 10:0.1 molar ratio and their size distribution and ζ-potential were characterized. Liposomes incorporating the doxorubicin-PAMAM complex exhibited release properties which were advantageous compared to the conventional type of liposomal doxorubicin in terms of doxorubicin toxicity and its availability to the tumor site. This liposomal formulation may show improved therapeutic properties in vivo
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Papagiannaros, A., Demetzos, C. (2007). Release Advantages of A Liposomal Dendrimer-Doxorubicin Complex, Over Conventional Liposomal Formulation of Doxorubicin. In: Mozafari, M.R. (eds) Nanomaterials and Nanosystems for Biomedical Applications. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6289-6_9
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DOI: https://doi.org/10.1007/978-1-4020-6289-6_9
Publisher Name: Springer, Dordrecht
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