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Calcium Signalling and Disease pp 465–480Cite as

Calcium and Cell Death

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 45))

Abstract

Calcium signalling system controls majority of cellular reactions. Calcium signals occurring within tightly regulated temporal and spatial domains, govern a host of Ca2+-dependent enzymes, which in turn determine specified cellular responses. Generation of Ca2+ signals is achieved through coordinated activity of several families of Ca2+ channels and transporters differentially distributed between intracellular compartments. Cell damage induced by environmental insults or by overstimulation of physiological pathways results in pathological Ca2+ signals, which trigger necrotic or apoptotic cellular death

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  1. Faculty of Life Sciences, The University of Manchester, 1.124 Stopford Building, Oxford Road, Manchester M13 9PT, UK

    A. VERKHRATSKY

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  1. University of Padova, Padova, Italy

    Ernesto Carafoli

  2. University of Padova, Padova, Italy

    Marisa Brini

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VERKHRATSKY, A. (2007). Calcium and Cell Death. In: Carafoli, E., Brini, M. (eds) Calcium Signalling and Disease. Subcellular Biochemistry, vol 45. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6191-2_17

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