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Applications of Mouse Models to the Study of Food Allergy

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Animal Models of Allergic Disease

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2223))

Abstract

Mouse models of allergic disease offer numerous advantages when compared to the models of other animals. However, selection of appropriate mouse models is critical to advance the field of food allergy by revealing mechanisms of allergy and for testing novel therapeutic approaches. All current mouse models for food allergy have weaknesses that may limit their applicability to human disease. Aspects such as the genetic predisposition to allergy or tolerance from the strain of mouse used, allergen dose, route of exposure (oral, intranasal, intraperitoneal, or epicutaneous), damage of the epithelial barrier, use of adjuvants, food matrix effects, or composition of the microbiota should be considered prior to the selection of a specific murine model and contemplated according to the intended purpose of the study. This chapter reviews our current knowledge on the application of mouse models to food allergy research and the variables that may influence the successful development of each type of model.

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Authors and Affiliations

  1. Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, Madrid, Spain

    Sara Benedé

  2. Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Sara Benedé & M. Cecilia Berin

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  1. Sara Benedé
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  2. M. Cecilia Berin
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Correspondence to M. Cecilia Berin .

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  1. Department of Biomedical Sciences, University of North Dakota School of Medicine & Health Sciences, Grand Forks, ND, USA

    Kumi Nagamoto-Combs

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Benedé, S., Berin, M.C. (2021). Applications of Mouse Models to the Study of Food Allergy. In: Nagamoto-Combs, K. (eds) Animal Models of Allergic Disease. Methods in Molecular Biology, vol 2223. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1001-5_1

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