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QSAR Approaches and Ecotoxicological Risk Assessment

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Ecotoxicological QSARs

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

Hundreds of thousands of chemicals that can affect human health or the quality of aquatic and terrestrial ecosystems are introduced directly or indirectly into the air, water, or soil. Therefore, the awareness of the serious and harmful effects caused by these chemical compounds has revealed the absolute and compelling need to resort to the evaluation of potential risks incurred as a result of exposure to these compounds. In the aim to provide a high level of protection for human, animal, and environmental health, many regulatory agencies have established strict legislation for both toxicological and ecotoxicological risk assessments of existing and new chemical compounds. To limit the in vivo experiments which are a tedious and costly practice and generate a large sacrifice of animals, the REACH regulation recommends the use of in silico methods, such as quantitative structure–activity relationship (QSAR) models.

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Authors and Affiliations

  1. Laboratoire des Biomatériaux et Phénomènes de Transport (LBMPT), Université Yahia Fares de Médéa, Medea, Algeria

    Mabrouk Hamadache, Othmane Benkortbi & Salah Hanini

  2. Univ Rennes, Ecole Nationale Supérieure de Chimie de Rennes, CNRS, ISCR - UMR 6226, F-35000, Rennes, France

    Abdeltif Amrane

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  1. Mabrouk Hamadache
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  2. Othmane Benkortbi
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  3. Abdeltif Amrane
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  4. Salah Hanini
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Correspondence to Abdeltif Amrane .

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  1. Drug Theoretics and Cheminformatics Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India

    Kunal Roy

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Hamadache, M., Benkortbi, O., Amrane, A., Hanini, S. (2020). QSAR Approaches and Ecotoxicological Risk Assessment. In: Roy, K. (eds) Ecotoxicological QSARs. Methods in Pharmacology and Toxicology. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0150-1_25

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  • DOI: https://doi.org/10.1007/978-1-0716-0150-1_25

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