Skip to main content

Adolescence is a time of many changes anatomically, physiologically, neurologically, and behaviorally. The age of adolescence is considered to be between 10 and 21 years. However, great variability exists in terms of the chronologic age at which complete adult maturity is achieved in any given individual. Additionally, the anatomic and physiologic portions of adolescence may be earlier to mature than the neurological and behavioral aspects. This discordance in development may lead to difficulties in the adolescent including promiscuity, risk-taking behaviors, and adolescents being treated according to their physical, not neurological, development. An adolescent who develops earlier or later than his or her peers also may experience teasing about one’s height and sexual development (or lack thereof). This chapter will discuss adolescent physiology with emphasis on the endocrine (hormonal) physiology and brain physiology. Case studies with examples of chronic disease in adolescents will also be presented.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bear, M. F., Connors, B. W., & Paradiso, M. A. (Eds.). (2007). Neuroscience: Exploring the brain (3rd ed.). Baltimore: Lippincott Williams & Wilkins

    Google Scholar 

  • Behrman, R. E., Kliegman, R. M., & Jenson, H. B. (2004). Nelson textbook of pediatrics (17th ed.). Philadelphia: Saunders.

    Google Scholar 

  • Brans, A. M., Biessels, G. J., deHaan, E. H., Kappelle, L. J., & Kessels, R. P. (March, 2005). The effects of type 1 diabetes on cognitive performance: a meta-analysis. Diabetes Care, 28(3), 726–735.

    Article  Google Scholar 

  • Brown, S. A., McGue, M., Maggs, J., Schulenberg, J., Hingson, R., Swartzwelder, S., et al. (April, 2008). A developmental perspective on alcohol and youths 16 to 20 years of age. Pediatrics, 121 Suppl 4, S290–S310.

    Article  PubMed  Google Scholar 

  • Bylund, D. B., & Reed, A. L. (October, 2007). Childhood and adolescent depression: Why do children and adults respond differently to antidepressant drugs? Neurochemistry International, 51(5), 246–253.

    Article  PubMed  Google Scholar 

  • Chugani, H. T. (November, 1998a). Biological basis of emotions: Brain systems and brain development. Pediatrics, 102(5 Suppl E), 1225–1229.

    PubMed  Google Scholar 

  • Chugani, H. T. (March–April, 1998b). A critical period of brain development: Studies of cerebral glucose utilization with PET. Preventive Medicine, 27(2), 184–188.

    Article  PubMed  Google Scholar 

  • Connan, F., Lightman, S. L., Landau, S., Wheeler, M., Treasure, J., & Campbell, I. C. (January-February, 2007). An investigation of hypothalamic-pituitary-adrenal axis hyperactivity in anorexia nervosa: The role of CRH and AVP. Journal of Psychiatric Research, 41(1–2), 131–143.

    Article  PubMed  Google Scholar 

  • Cox, D. J., Kovatchev, B. P., Gonder-Frederick, L. A., Summers, K. H., McCall, A., Grimm, K. J., et al. (January, 2005). Relationships between hyperglycemia and cognitive performance among adults with type 1 and type 2 diabetes. Diabetes Care, 28(1), 71–77.

    Article  PubMed  Google Scholar 

  • Crow, S. J., Keel, P. K., & Kendall, D. (1998). Eating disorders and insulin-dependent diabetes mellitus. Psychosomatics, 39(3), 233–243.

    PubMed  Google Scholar 

  • Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., et al. (1999) Brain development during childhood and adolescence: A longitudinal MRI study. New York: Nature America Inc.

    Google Scholar 

  • Ginsburg, K., & Jablow, M. M. (2002). But I’m almost 13! An action plan for raising a responsible adolescent. New York: Contemporary Books.

    Google Scholar 

  • Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., et al. (May 25, 2004) Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the United States of America, 101(21), 8174–8179.

    Article  PubMed  Google Scholar 

  • Herpertz, S., Albus, C., Wagener, R., Kocnar, M., Wagner, R., Henning, A., et al. (July, 1998). Comorbidity of diabetes and eating disorders. Does diabetes control reflect disturbed eating behavior? Diabetes Care, 21(7), 1110–1116.

    Article  PubMed  Google Scholar 

  • Herpertz, S., von Blume, B., & Senf, W. (1995). Eating disorders and diabetes mellitus. Z Psychosom Med Psychoanal, 41(4), 329–343.

    PubMed  Google Scholar 

  • Higgins, E. S., & George, M. S. (2007). The neuroscience of clinical psychiatry, the pathophysiology of behavior and mental illness. Philadelphia: Lippincott Williams & Wilkins.

    Google Scholar 

  • Kappy, M. S., Allen, D. B., & Geffner, M. E. (2005). Principles and practice of pediatric endocrinology. Springfield, IL: Charles C Thomas Publisher.

    Google Scholar 

  • Kaufman, F. R., Epport, K., Engilman, R., & Halvorson, M. (January–February, 1999). Neurocognitive functioning in children diagnosed with diabetes before age 10 years. Journal of Diabetes and Its Complications, 13(1), 31–38.

    Article  PubMed  Google Scholar 

  • Lawson, E. A., & Klibanski, A. (July, 2008). Endocrine abnormalities in anorexia nervosa. Nature Clinical Practice. Endocrinology & Metabolism, 4(7), 407–414.

    Article  Google Scholar 

  • Licinio, J., Wong, M. L., & Gold, P. W. (April 16, 1996). The hypothalamic-pituitary-adrenal axis in anorexia nervosa. Psychiatry Research, 62(1), 75–83.

    Article  PubMed  Google Scholar 

  • Marshall, W. A., & Tanner, J. M. (1969). Variations in pattern of pubertal changes in girls. Archives of Disease in Childhood, 44, 291.

    Article  PubMed  Google Scholar 

  • Marshall, W. A., & Tanner, J. M. (1970). Variations in pattern of pubertal changes in boys. Archives of Disease in Childhood , 45, 13

    Article  PubMed  Google Scholar 

  • Murrin, L. C., Sanders, J. D., & Bylund, D. B. (2007). Comparison of the maturation of the adrenergic and serotonergic neurotransmitter systems in the brain: Implications for differential drug effects on juveniles and adults. Biochemical Pharmacology, 73(8):1225–1236. (PMID: 17316571).

    Google Scholar 

  • Naguib, J. M., Kulinskaya, E., Lomax, C. L., & Garralda, M. E. (July 17, 2008). Neuro-cognitive performance in children with type I diabetes-a meta-analysis. Journal of Pediatric Psychology.

    Google Scholar 

  • Northam, E., Bowden, S., Anderson, V., & Court, J. (November, 1992). Neuropsychological functioning in adolescents with diabetes. Journal of Clinical and Experimental Neuropsychology, 14(6), 884–900.

    Article  PubMed  Google Scholar 

  • Northam, E. A., Anderson, P. J., Jacobs, R., Hughes, M., Warne, G. L., & Werther, G. A. (September, 2001). Neuropsychological profiles of children with type 1 diabetes 6 years after disease onset. Diabetes Care, 24(9), 1541–1546.

    Article  PubMed  Google Scholar 

  • Porterfield, S. P. (1997). Endocrine physiology. St. Louis, MO: Mosby-Year Book, Inc.

    Google Scholar 

  • Purves, D., Augustine, G. J., Fitzpatrick, D., Hall, W. C., LaMantia, A-S., McNamara, J. O., et al. (2004). Neuroscience (3rd ed.). Sunderland, MA: Sinauer Associates Inc.

    Google Scholar 

  • Romeo, R. D., & McEwen, B. S. (December, 2006). Stress and the adolescent brain. Annals of the New York Academy of Sciences, 1094, 226–234.

    Article  Google Scholar 

  • Snell, R. S. (2001). Clinical neuroanatomy: A illustrated review with questions and explanations (3rd ed.). Philadelphia: Lippincott Williams & Wilkins.

    Google Scholar 

  • Sowell, E. R. , Thompson, P. M., Holmes, C. J., Jernigan, T. L., & Toga, A. W. (1999). In vivo evidence for post-adolescent brain maturation in frontal and striatal regions. New York: Nature America Inc.

    Google Scholar 

  • Sperling, M. A. (2008). Pediatric endocrinology (3rd ed.). Philadelphia: Saunders Elsevier.

    Google Scholar 

  • Steinberg, L. (March, 2008). A social neuroscience perspective on adolescent risk-taking. Developmental Review, 28(1), 78–106.

    Article  PubMed  Google Scholar 

  • Takii, M., Komaki, G., Uchigata, Y., Maeda, M., Omori, Y., & Kubo, C. (September, 1999). Differences between bulimia nervosa and binge-eating disorder in females with type 1 diabetes: The important role of insulin omission. Journal of Psychosomatic Research, 47(3), 221–231.

    Article  PubMed  Google Scholar 

  • Windle, M., Spear, L. P., Fuligni, A. J., Angold, A., Brown, J. D., Pine, D., et al. (2008). Transitions into underage and problem drinking: Developmental processes and mechanisms between 10 and 15 years of age. Pediatrics, 121, S273–S289.

    Article  PubMed  Google Scholar 

  • Young, P. A., Young, P. H., & Tolbert, D. L. (2008). Clinical neuroscience (2nd ed.). Philadelphia: Lippincott Williams & Wilkins.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kathryn L. Eckert .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Eckert, K.L., Loffredo, V.A., O’Connor, K. (2009). Adolescent Physiology. In: O'Donohue, W. (eds) Behavioral Approaches to Chronic Disease in Adolescence. Springer, New York, NY. https://doi.org/10.1007/978-0-387-87687-0_4

Download citation

Publish with us

Policies and ethics