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Potential Protective Effects of Probiotics and Prebiotics Against Colorectal Cancer

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Prebiotics and Probiotics Science and Technology

Abstract

Colorectal cancer (CRC) is the fourth most frequent cause of cancer related mortality in the world. Approximately 944,000 new cases were diagnosed globally in 2000 and this accounts for 9.2% of all new cancer cases (IARC, 2000). In Western societies namely Europe, North America and Australasia, it is the second most prevalent cancer after lung/breast (Boyle and Langman, 2000). About 363,000 new cases were reported in Europe in 2000 and it affects 6% of men and women by age 75, in almost equal proportion.

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Abbreviations

ACF :

aberrant crypt foci

AOM :

azoxymethane

CRC :

Colorectal cancer

DMH :

1,2-dimethylhydrazine

FOS :

fructo-oligosaccharide

Glu-P-1 :

2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole

Glu-P-2 :

2-aminodipyrido[1,2-a:3′,2′-d]imidazole

HFA :

human flora associated

IQ :

2-amino-3-methyl-3H-imidazo(4,5-f)quinoline

LAB :

lactic acid producing bacteria

MeIQ :

2-amino3,4-dimethylimidazo[4,5-f]quinoline

MeIQx :

2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

MNNG :

N-methyl-N’-nitro-N-nitrosoguanidine

NDO :

non-digestible oligosaccharide

PhIP :

2-amino-1-methyl-6-phenylimidazo-[4,5b]pyridine

TOS :

trans-galactosylated oligosaccharide

Trp-P-1 :

3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]indole

Trp-P-2 :

3-amino-1-methyl-5H-pyrido[4,3b]indole

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Authors and Affiliations

  1. Northern Ireland Centre for Food and Health, Centre for Molecular Biosciences, University of Ulster, Coleraine, UK

    Philip Allsopp

  2. Hugh Sinclair Unit for Human Nutrition, Department of Food Biosciences, University of Reading, Whiteknights, UK

    Ian Rowland

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  1. Philip Allsopp
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  2. Ian Rowland
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  1. Department of Food Biosciences, University of Reading Whiteknights, Reading, UK

    Dimitris Charalampopoulos  & Robert A. Rastall  & 

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Allsopp, P., Rowland, I. (2009). Potential Protective Effects of Probiotics and Prebiotics Against Colorectal Cancer. In: Charalampopoulos, D., Rastall, R.A. (eds) Prebiotics and Probiotics Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79058-9_26

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