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Mitochondria pp 185–196Cite as

Formation of Reactive Oxygen Species in Mitochondria

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Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 2))

Abstract

Living organisms obtain energy from the oxidation of various biomolecules, including carbohydrates, lipids and the carbon skeletons of amino acids. Under aerobic conditions, the reducing coenzymes produced during these reactions are re-oxidized in the electron transport chain, transferring electrons to molecular oxygen (E°= +800 mV) through a series of electron carriers in the respiratory chain. This electrochemical energy is converted into a proton gradient which, in turn, operates a rotor-type enzymatic complex (ATP synthase or Complex V), inducing conformational changes which cause ADP and inorganic phosphate to bind to the active site and ATP to be released (Noji and Yoshida 2001).

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Authors
  1. Julio F. Turrens
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Editors and Affiliations

  1. Department of Pharmacology, University of South Alabama, Mobile, AL, 36688-0001, USA

    Stephen W. Schaffer

  2. Bristol Royal Infirmary, Bristol, BS2 8HW, UK

    M-Saadeh Suleiman

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Turrens, J.F. (2007). Formation of Reactive Oxygen Species in Mitochondria. In: Schaffer, S.W., Suleiman, MS. (eds) Mitochondria. Advances in Biochemistry in Health and Disease, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69945-5_8

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