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Modeling Human Philadelphia Chromosome-Positive Leukemia in Mice

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Abstract

The BCR-ABL oncogene tranforms cells through sustained activation of signal transduction pathways in the cells. Identification of signaling pathways that play critical roles in leukemogenesis is the key to developing effective therapies against these targets. The success of this approach relies on establishment and use of physiological disease models to determine and evaluate potential therapeutic targets. Mouse models provide a powerful tool for studying signaling pathways in leukemic cells and for developing new therapeutic strategies for treating leukemia patients.

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    Shaoguang Li

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    Li, S. (2008). Modeling Human Philadelphia Chromosome-Positive Leukemia in Mice. In: Li, S. (eds) Mouse Models of Human Blood Cancers. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69132-9_7

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