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Influenza Viral Infection: Stress-induced Modulation of Innate Resistance and Adaptive Immunity

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Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity

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Abstract

If you believe what you read in the newspapers, the world is poised for a pandemic. The scourge is likely to be infection with the influenza A virus. Although there may be some doubt concerning these cataclysmic predictions, they are based on solid epidemiological and historical data. It is well documented that during the past several centuries, an influenza virus pandemic has raced through the human population every 20–40 years or so. In 1918–1919, a pandemic due to influenza virus infected one out of every five humans. This “Spanish Flu,” which was also known as “La Grippe,” is estimated to have killed more than 30 million people in less than 2 years (Mills et al., 2004). To put this in perspective, this influenza pandemic killed one out of every four soldiers that died during World War I (Oxford et al., 2005). Luckily, there has not been a repeat of the 1918–1919 pandemic. However, recent events such as the emergence of the avian influenza that is currently causing mortality in Asia may signal the evolution of a new, highly virulent influenza virus that might cause a serious worldwide influenza epidemic.

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References

  • Adler, N.E., Boyce, T., Chesney, M.A., Cohen, S., Folkman, S., Kahn, R.L., and Syme, L.S. (1994). Socioeconomic status and health: The challenge of the gradient. Am. Psychol. 49:15–24.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, R.N., and Smith, B.L. (2005). Deaths: Leading causes for 2002. National Vital Statistics Report 53:1–89.

    Google Scholar 

  • Avitsur, R., Stark, J.L., and Sheridan, J.F. (2001). Social stress induces glucocorticoid resistance in subordinate animals. Horm. Behav. 39:247–257.

    Article  PubMed  CAS  Google Scholar 

  • Avitsur, R., Padgett, D.A., Dhabhar, F.S., Stark, J.L., Kramer, K.A., Engler, H., and Sheridan, J.F. (2003a). Expression of glucocorticoid resistance following social stress requires a second signal. J. Leukoc. Biol. 74:507–513.

    Article  PubMed  CAS  Google Scholar 

  • Avitsur, R., Stark, J.L., Dhabhar, F.S., Kramer, K.A., and Sheridan, J.F. (2003b). Social experience alters the response to social stress in mice. Brain Behav. Immun. 17:426–437.

    Article  PubMed  Google Scholar 

  • Badovinac, V.P., Tvinnereim, A.R., and Harty, J.T. (2000). Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science 290: 1354–1358.

    Article  PubMed  CAS  Google Scholar 

  • Bailey, M., Engler, H., Hunzeker, J., and Sheridan, J.F. (2003). The hypothalamic-pituitary-adrenal axis and viral infection. Viral Immunol. 16:141–157.

    Article  PubMed  CAS  Google Scholar 

  • Barchet, W., Krug, A., Cella, M., Newby, C., Fischer, J.A., Dzionek, A., Pekosz, A., and Colonna, M. (2005). Dendritic cells respond to influenza virus through TLR7-and PKR-independent pathways. Eur. J. Immunol. 35:236–242.

    Article  PubMed  CAS  Google Scholar 

  • Barnes, B., Lubyova, B., and Pitha, P.M. (2002). On the role of IRF in host defense. J. Interferon Cytokine Res. 22:59–71.

    Article  PubMed  CAS  Google Scholar 

  • Biron, C.A., Nguyen, K.B., Pien, G.C., Cousens, L.P., and Salazar-Mather, T.P. (1999). Natural killer cells in antiviral defense: Function and regulation by innate cytokines. Annu. Rev. Immunol. 17:189–220.

    Article  PubMed  CAS  Google Scholar 

  • Bonneau, R.H., Sheridan, J.F., Feng, N., and Glaser, R. (1991). Stress-induced suppression of herpes simplex virus (HSV)-specific cytotoxic T lymphocyte and natural killer cell activity and enhancement of acute pathogenesis following local HSV infection. Brain Behav. Immun. 5:170–192.

    Article  PubMed  CAS  Google Scholar 

  • Brokstad, K.A., Cox, R.J., Major, D., Wood, J.M., and Haaheim, L.R. (1995). Crossreaction but no avidity change of the serum antibody response after influenza vaccination. Vaccine 13:1522–1528.

    Article  PubMed  CAS  Google Scholar 

  • Cella, M., Facchetti, F., Lanzavecchia, A., and Colonna, M. (2000). Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization. Nat. Immunol. 1:305–310.

    Article  PubMed  CAS  Google Scholar 

  • Chambers, B.J., Wilson, J.L., Salcedo, M., Markovic, K., Bejarano, M.T., and Ljunggren, H.G. (1998). Triggering of natural killer cell mediated cytotoxicity by costimulatory molecules. Curr. Topics Microbiol. Immunol. 23:53–61.

    Google Scholar 

  • Chambers, C.A., and Allison, J.P. (1997). Co-stimulation in T cell responses. Curr. Opin. Immunol. 9:396–404.

    Article  PubMed  CAS  Google Scholar 

  • Conn, C.A., McClellan, J.L., Maassab, H.F., Smitka, C.W., Majde, J.A., and Kluger, M.J. (1995). Cytokines and the acute phase response to influenza virus in mice. Am. J. Physiol. 268:R78–R84.

    PubMed  CAS  Google Scholar 

  • Cook, D., Beck, M.A., Coffman, T.M., Kirby, S.L., Sheridan, J.F., Pragnell, I.B., and Smithies, O. (1995). Requirement of MIP-1α for an inflammatory response to viral infection. Science 269:1583–1585.

    Article  PubMed  CAS  Google Scholar 

  • Cox, R.J., Brokstad, K.A., Zuckerman, M.A., Wood, J.M., Haaheim, L.R., and Oxford, J.S. (1994). An early humoral immune response in peripheral blood following parenteral inactivated influenza vaccination. Vaccine 12:993–999.

    Article  PubMed  CAS  Google Scholar 

  • Darnell, J.E. Jr, Kerr, I.M., and Stark, G.R. (1994). Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415–1421.

    Article  PubMed  CAS  Google Scholar 

  • Debes, G.F., Bonhagen, K., Wolff, T., Kretschmer, U., Krautwald, S., Kamradt, T., and Hamann, A. (2004). CC chemokine receptor 7 expression by effector/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza A virus infection. J. Virol. 78:7528–7535.

    Article  PubMed  CAS  Google Scholar 

  • Deng, Y., Jing, Y., Campbell, A.E., and Gravenstein, S. (2004). Age-related impaired type 1 T cell responses to influenza: reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly. J. Immunol. 172:3437–3446.

    PubMed  CAS  Google Scholar 

  • Diebold, S.S., Kaisho, T., Hemmi, H., Akira, S., and Reis e Sousa, C. (2004). Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303:1529–1531.

    Article  PubMed  CAS  Google Scholar 

  • Dobbs, C.M., Vasquez, M., Glaser, R., and Sheridan, J.F. (1993). Mechanisms of stress-induced modulation of viral pathogenesis and immunity. J. Neuroimmunol. 48:151–160.

    Article  PubMed  CAS  Google Scholar 

  • Dobbs, C.M., Feng, N., Beck, F.M., and Sheridan, J.F. (1996). Neuroendocrine regulation of cytokine production during experimental influenza viral infection: Effects of restraint stress-induced elevation in endogenous corticosterone. J. Immunol. 157:1870–1877.

    PubMed  CAS  Google Scholar 

  • Doherty, P.C., Riberdy, J.M., and Belz, G.T. (2000). Quantitative analysis of the D8+ T-cell response to readily eliminated and persistent viruses. Philos. Trans. R. Soc. London B Biol. Sci. 355:1093–1101.

    Article  PubMed  CAS  Google Scholar 

  • el Madhun, A.S., Cox, R.J., Soreide, A., Olofsson, J., and Haaheim, L.R. (1998). Systemic and mucosal immune responses in young children and adults after parenteral influenza vaccination. J. Infect. Dis. 178:933–939.

    PubMed  Google Scholar 

  • Feng, N., Pagniano, R., Tovar, C.R., Bonneau, R.H., Glaser, R., and Sheridan, J.F. (1991). The effect of restraint stress on the kinetics, magnitude, and isotype of the humoral immune response to influenza virus infection. Brain Behav. Immun. 5: 370–382.

    Article  PubMed  CAS  Google Scholar 

  • Finberg, R.W., and Kurt-Jones, E.A. (2004). Viruses and Toll-like receptors. Microbes Infect. 6:1356–1360.

    Article  PubMed  CAS  Google Scholar 

  • Flynn, K.J., Riberdy, J.M., Christensen, J.P., Altman, J.D., and Doherty, P.C. (1999). In vivo proliferation of naive and memory influenza-specific CD8(+) T cells. Proc. Natl. Acad. Sci. U.S.A. 96:8597–8602.

    Article  PubMed  CAS  Google Scholar 

  • Fonteneau, J.F., Gilliet, M., Larsson, M., Dasilva, I., Munz, C., Liu, Y.J., and Bhardwaj, N. (2003). Activation of influenza virus-specific CD4+ and CD8+ T cells: A new role for plasmacytoid dendritic cells in adaptive immunity. Blood 101:3520–3526.

    Article  PubMed  CAS  Google Scholar 

  • Forster, R., Mattis, A.E., Kremmer, E., Wolf, E., Brem, G., and Lipp, M. (1996). A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87:1037–1047.

    Article  PubMed  CAS  Google Scholar 

  • Geginat, J., Lanzavecchia, A., and Sallusto, F. (2003a). Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines. Blood 101:4260–4266.

    Article  PubMed  CAS  Google Scholar 

  • Geginat, J., Sallusto, F., and Lanzavecchia, A. (2003b). Cytokine-driven proliferation and differentiation of human naive, central memory and effector memory CD4+ T cells. Pathol. Biol. (Paris), 51:64–66.

    CAS  Google Scholar 

  • Gerhard, W., Mozdzanowska, K., Furchner, M., Washko, G., and Maiese, K. (1997). Role of the B-cell response in recovery of mice from primary influenza virus infection. Immunol. Rev. 159:95–103.

    Article  PubMed  CAS  Google Scholar 

  • Glaser, R., Kiecolt-Glaser, J.K., Bonneau, R., Malarkey, W., and Hughes, J. (1992). Stress-induced modulation of the immune response to recombinant hepatitis B vaccine. Psychosom. Med. 54:22–29.

    PubMed  CAS  Google Scholar 

  • Glaser, R., Sheridan, J.F., Malarkey, W.B., MacCallum, R.C., and Kiecolt-Glaser, J.K. (2000). Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine. Psychosom. Med. 62:804–807.

    PubMed  CAS  Google Scholar 

  • Hashimoto, G., Wright, P.F., and Karzon, D.T. (1983). Antibody-dependent cell-mediated cytotoxicity against influenza virus-infected cells. J. Infect. Dis. 148: 785–794.

    PubMed  CAS  Google Scholar 

  • Hermann, G., Tovar, C.A., Beck, F.M., Allen, C., and Sheridan, J.F. (1993). Restraint stress differentially affects the pathogenesis of an experimental influenza viral infection in three inbred strains of mice. J. Neuroimmunol. 47:83–94

    Article  PubMed  CAS  Google Scholar 

  • Hermann, G., Beck, F.M., and Sheridan, J.F. (1995). Stress-induced glucocorticoid response modulates mononuclear cell trafficking during an experimental influenza viral infection. J. Neuroimmunol. 56:179–186.

    Article  PubMed  CAS  Google Scholar 

  • Hordijk, P. (2003). Endothelial signaling in leukocyte transmigration. Cell Biochem. Biophys. 38:305–322.

    Article  PubMed  CAS  Google Scholar 

  • Hornung, V., Schlender, J., Guenthner-Biller, M., Rothenfusser, S., Endres, S., Conzelmann, K.K., and Hartmann, G. (2004). Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus. J. Immunol. 173:5935–5943.

    PubMed  CAS  Google Scholar 

  • Hou, S., Hyland, L., Ryan, K.W., Portner, A., and Doherty, P.C. (1994). Virus-specific CD8+ T-cell memory determined by clonal burst size. Nature 369:652–654.

    Article  PubMed  CAS  Google Scholar 

  • Hovanessian, A.G. (1991). Interferon-induced and double-stranded RNA-activated enzymes: a specific protein kinase and 2′,5′-oligoadenylate synthetases. J. Interferon Res. 11:199–205.

    PubMed  CAS  Google Scholar 

  • Hunzeker, J. (2004). Differential Effects of Stress on the Immune Response to Influenza A/PR8 Virus Infection in Mice. Ph.D. dissertation, The Ohio State University, Columbus.

    Google Scholar 

  • Hunzeker, J., Padgett, D.A., Sheridan, P.A., Dhabhar, F.S., and Sheridan, J.F. (2004). Modulation of natural killer cell activity by restraint stress during an influenza A/PR8 infection in mice. Brain Behav. Immun. 18:526–535.

    Article  PubMed  CAS  Google Scholar 

  • Iezzi, G., Karjalainen, K., and Lanzavecchia, A. (1998). The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8:89–95.

    Article  PubMed  CAS  Google Scholar 

  • Ishigami, T. (1919). The influence of psychic acts on the progress of pulmonary tuberculosis. Am. Rev. Tuberculosis 2:470–484.

    Google Scholar 

  • Jegerlehner, A., Schmitz, N., Storni, T., and Bachmann, M.F. (2004). Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity. J. Immunol. 172:5598–5605.

    PubMed  CAS  Google Scholar 

  • Jelley-Gibbs, D.M., Lepak, N.M., Yen, M., and Swain, S.L. (2000). Two distinct stages in the transition from naive CD4 T cells to effectors, early antigen-dependent and late cytokine-driven expansion and differentiation. J. Immunol. 165:5017–5026.

    PubMed  CAS  Google Scholar 

  • Johansson, B.E., Bucher, D.J., and Kilbourne, E.D. (1989). Purified influenza virus hemagglutinin and neuraminidase are equivalent in stimulation of antibody response but induce contrasting types of immunity to infection. J. Virol. 63: 1239–1246.

    PubMed  CAS  Google Scholar 

  • Johansson, B.E., Matthews, J.T., and Kilbourne, E.D. (1998). Supplementation of conventional influenza A vaccine with purified viral neuraminidase results in a balanced and broadened immune response. Vaccine 16:1009–1015.

    Article  PubMed  CAS  Google Scholar 

  • Johansson, B.E., Pokorny, B.A., and Tiso, V.A. (2002). Supplementation of conventional trivalent influenza vaccine with purified viral N1 and N2 neuraminidases induces a balanced immune response without antigenic competition. Vaccine 20: 1670–1674.

    Article  PubMed  CAS  Google Scholar 

  • Julkunen, I., Melen, K., Nyqvist, M., Pirhonen, J., Sareneva, T., and Matikainen, S. (2000). Inflammatory responses in influenza A virus infection. Vaccine 19(Suppl 1): S32–S37.

    Article  PubMed  CAS  Google Scholar 

  • Julkunen, I., Sareneva, T., Pirhonen, J., Ronni, T., Melen, K., and Matikainen, S. (2001). Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression. Cytokine Growth Factor Rev. 12:171–180.

    Article  PubMed  CAS  Google Scholar 

  • Kaech, S.M., and Ahmed, R. (2001). Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2:415–422.

    PubMed  CAS  Google Scholar 

  • Kaech, S.M., Wherry, E.J., and Ahmed, R. (2002). Effector and memory T-cell differentiation: Implications for vaccine development. Nat. Rev. Immunol. 2:251–262.

    Article  PubMed  CAS  Google Scholar 

  • Kaech, S.M., Tan, J.T., Wherry, E.J., Konieczny, B.T., Surh, C.D., and Ahmed, R. (2003). Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4:1191–1198.

    Article  PubMed  CAS  Google Scholar 

  • Kagi, D., Odermatt, B., and Mak, T.W. (1999). Homeostatic regulation of CD8+ T cells by perforin. Eur. J. Immunol. 29:3262–3272.

    Article  PubMed  CAS  Google Scholar 

  • Kaisho, T., and Akira, S. (2004). Pleiotropic function of Toll-like receptors. Microbes Infect. 6:1388–1394.

    Article  PubMed  CAS  Google Scholar 

  • Katze, M.G., He, Y., and Gale, M. Jr. (2002). Viruses and interferon: A fight for supremacy. Nat. Rev. Immunol. 2:675–687.

    Article  PubMed  CAS  Google Scholar 

  • Kaufmann, A., Salentin, R., Meyer, R.G., Bussfeld, D., Pauligk, C., Fesq, H., Hofmann, P., Nain, M., Gemsa, D., and Sprenger, H. (2001). Defense against influenza A virus interferon: Essential role of the chemokine system. Immunobiology 204:603–613.

    Article  PubMed  CAS  Google Scholar 

  • Kiecolt-Glaser, J., Glaser, R., Gravenstein, S., Malarkey, W.B., and Sheridan, J.F. (1996). Chronic stress alters the immune response to influenza virus vaccine in older adults. Proc. Natl. Acad. Sci. U.S.A. 93:3043–3047.

    Article  PubMed  CAS  Google Scholar 

  • Koolhass, J.M., De Boer, S.F., De Ruiter, A.J.H., Meerlo, P., and Sgoifo, A. (1997). Social stress in rats and mice. Acta Physiol. Scand. 161(S640):69–72.

    Google Scholar 

  • Knossow, M., Gaudier, M., Douglas, A., Barrere, B., Bizebard, T., Barbey, C., Gigant, B., and Skehel, J.J. (2002). Mechanism of neutralization of influenza virus infectivity by antibodies. Virology 302:294–298.

    Article  PubMed  CAS  Google Scholar 

  • Konstantinos, A.P., and Sheridan, J.F. (2001). Stress and influenza viral infection: Modulation of proinflammatory cytokine responses in the lung. Respir. Physiol. 128:71–77.

    Article  PubMed  CAS  Google Scholar 

  • Lanier, L.L. (1998). NK cell receptors. Annu. Rev. Immunol. 16:359–393.

    Article  PubMed  CAS  Google Scholar 

  • Lanzavecchia, A., Lezzi, G., and Viola, A. (1999). From TCR engagement to T cell activation: A kinetic view of T cell behavior. Cell 96:1–4.

    Article  PubMed  CAS  Google Scholar 

  • Lenz, D.C., Kurz, S.K., Lemmens, E., Schoenberger, S.P., Sprent, J., Oldstone, M.B., and Homann, D. (2004). IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory. Proc. Natl. Acad. Sci. U.S.A. 101:9357–9362.

    Article  PubMed  CAS  Google Scholar 

  • Leung, K.N., and Ada, G.L. (1981). Induction of natural killer cells during murine influenza virus infection. Immunobiology 160:352–366.

    PubMed  CAS  Google Scholar 

  • Liu, B., Mori, I., Hossain, M.J., Dong, L., Chen, Z., and Kimura, Y. (2003). Local immune responses to influenza virus infection in mice with a targeted disruption of perforin gene. Microb. Pathogen. 34:161–167.

    Article  CAS  Google Scholar 

  • Lodolce, J.P., Burkett, P.R., Boone, D.L., Chien, M., and Ma, A. (2001). T cell-independent interleukin 15Ralpha signals are required for bystander proliferation. J. Exp. Med. 194:1187–1194.

    Article  PubMed  CAS  Google Scholar 

  • Lopez, C.B., Moran, T.M., Schulman, J.L., and Fernandez-Sesma, A. (2002). Antiviral immunity and the role of dendritic cells. Int. Rev. Immunol. 21:339–353.

    Article  PubMed  CAS  Google Scholar 

  • Lund, J.M., Alexopoulou, L., Sato, A., Karow, M., Adams, N.C., Gale, N.W., Iwasaki, A., and Flavell, R.A. (2004). Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl. Acad. Sci. U.S.A. 101:5598–5603.

    Article  PubMed  CAS  Google Scholar 

  • Ma, A., Boone, D.L., and Lodolce, J.P. (2000). The pleiotropic functions of interleukin 15: Not so interleukin 2-like after all. J. Exp. Med. 191:753–756.

    Article  PubMed  CAS  Google Scholar 

  • MacArthur Network on Socioeconomic Status and Health. (1997). Revised 6/3/2003. Available at http://www.macses.ucsf.edu/Default.htm.

  • MacLennan, I.C. (1994). Germinal centers. Annu. Rev. Immunol. 12:117–139.

    Article  PubMed  CAS  Google Scholar 

  • Mailliard, R.B., Egawa, S., Cai, Q., Kalinska, A., Bykovskaya, S.N., Lotze, M.T., Kapsenberg, M.L., Storkus, W.J., and Kalinski, P. (2002). Complementary dendritic cell-activating function of CD8+ and CD4+ T cells: Helper role of CD8+ T cells in the development of T helper type 1 responses. J. Exp. Med. 195:473–483.

    Article  PubMed  CAS  Google Scholar 

  • Matloubian, M., Suresh, M., Glass, A., Galvan, M., Chow, K., Whitmire, J.K., Walsh, C.M., Clark, W.R., and Ahmed, R. (1999). A role for perforin in downregulating T-cell responses during chronic viral infection. J. Virol. 73:2527–2536.

    PubMed  CAS  Google Scholar 

  • Matrosovich, M.N., Matrosovich, T.Y., Gray, T., Roberts, N.A., and Klenk, H.D. (2004). Human and avian influenza viruses target different cell types in cultures of human airway epithelium. Proc. Natl. Acad. Sci. U.S.A. 101:4620–4624.

    Article  PubMed  CAS  Google Scholar 

  • McEwen, B.S. Protective and damaging effects of stress mediators. (1998). N. Engl. J. Med. 338:171–179.

    Google Scholar 

  • McHale, J.F., Harari, O.A., Marshall, D., and Haskard, D.O. (1999). TNF-alpha and IL-1 sequentially induce endothelial ICAM-1 and VCAM-1 expression in MRL/lpr lupus-prone mice. J. Immunol. 163:3993–4000.

    PubMed  CAS  Google Scholar 

  • Mellon, R.D., and Bayer, B.M. (1998). Role of central opioid receptor subtypes in morphine induced alterations in peripheral lymphocyte activity. Brain Res. 789: 56–67.

    Article  PubMed  CAS  Google Scholar 

  • Mills, C.E., Robins, J.M., and Lipsitch, M. (2004). Transmissibility of 1918 pandemic influenza. Nature 432:904–906.

    Article  PubMed  CAS  Google Scholar 

  • Nelson, C.J., and Lysle, D.T. (2001). Involvement of substance P and central opioid receptors in morphine modulation of the CHS response. J. Neuroimmunol. 115: 101–110.

    Article  PubMed  CAS  Google Scholar 

  • Nieto, M., Rodriguez-Fernandez, J.L., Navarro, F., Sancho, D., Frade, J.M., Mellado, M., Martinez-A, C., Cabanas, C., and Sanchez-Madrid, F. (1999). Signaling through CD43 induces natural killer cell activation, chemokine release, and PYK-2 activation. Blood 94:2767–2777.

    PubMed  CAS  Google Scholar 

  • Okada, T., Ngo, V.N., Ekland, E.H., Forster, R., Lipp, M., Littman, D.R., and Cyster, J.G. (2002). Chemokine requirements for B cell entry to lymph nodes and Peyer’s patches. J. Exp. Med. 196:65–75.

    Article  PubMed  CAS  Google Scholar 

  • Oran, A.E., and Robinson, H.L. (2004). DNA vaccines: influenza virus challenge of a Th2/Tc2 immune response results in a Th2/Tc1 response in the lung. J. Virol. 78:4376–4380.

    Article  PubMed  CAS  Google Scholar 

  • Oxford, J.S., Lambkin, R., Sefton, A., Daniels, R., Elliot, A., Brown, R., and Gill, D. (2005). A hypothesis: The conjunction of soldiers, gas, pigs, ducks, geese and horses in northern France during the Great War provided the conditions for the emergence of the “Spanish” influenza pandemic of 1918–1919. Vaccine 23:940–945.

    Article  PubMed  CAS  Google Scholar 

  • Padgett, D.A., Loria, R.M. (1994). In vitro potentiation of lymphocyte activation by dehydroepiandrosterone, androstenediol, and androstenetriol. J. Immunol. 153: 1544–1552.

    PubMed  CAS  Google Scholar 

  • Padgett, D.A., and Sheridan, J.F. (1999). Androstenediol (AED) prevents neuroendocrine-mediated suppression of the immune response to an influenza viral infection. J. Neuroimmunol. 98:121–129.

    Article  PubMed  CAS  Google Scholar 

  • Pasare, C., and Medzhitov, R. (2004). Toll-like receptors: linking innate and adaptive immunity. Microbes Infect. 6:1382–1387.

    Article  PubMed  CAS  Google Scholar 

  • Pevzner, V., Wolf, I., Burgstahler, R., Forster, R., and Lipp, M. (1999). Regulation of expression of chemokine receptor BLR1/CXCR5 during B cell maturation. Curr. Topics Microbiol. Immunol. 246:79–84.

    CAS  Google Scholar 

  • Proietti, E., Bracci, L., Puzelli, S., Di Pucchio, T., Sestili, P., De Vincenzi, E., Venditti, M., Capone, I., Seif, I., De Maeyer, E., Tough, D., Donatelli, I., and Belardelli, F. (2002). Type I IFN as a natural adjuvant for a protective immune response: Lessons from the influenza vaccine model. J. Immunol. 169:375–383.

    PubMed  CAS  Google Scholar 

  • Qin, D., Wu, J., Vora, K.A., Ravetch, J.V., Szakal, A.K., Manser, T., and Tew, J.G. (2000). Fc gamma receptor IIB on follicular dendritic cells regulates the B cell recall response. J. Immunol. 164:6268–6275.

    PubMed  CAS  Google Scholar 

  • Quan, N., Avitsur, R., Stark, J.L., He, L., Shah, M., Caliguiri, M., Padgett, D.A., Marucha, P.T., and Sheridan, J.F. (2001). Social stress increases the susceptibility to endotoxic shock. J. Neuroimmunol. 115:36–45.

    Article  PubMed  CAS  Google Scholar 

  • Quan, N., Avitsur, R., Stark, J.L., He, L., Lai, W., Dhabhar, F.S., and Sheridan, J.F. (2003). Molecular mechanisms of glucocorticoid resistance in splenocytes of socially stressed male mice. J. Neuroimmunol. 137:51–58.

    Article  PubMed  CAS  Google Scholar 

  • Randolph, G.J., and Furie, M.B. (1995). A soluble gradient of endogenous monocyte chemoattractant protein-1 promotes the transendothelial migration of monocytes in vitro. J. Immunol. 155:3610–3618.

    PubMed  CAS  Google Scholar 

  • Rosseau, S., Selhorst, J., Wiechmann, K., Leissner, K., Maus, U., Mayer, K., Grimminger, F., Seeger, W., and Lohmeyer, J. (2000). Monocyte migration through the alveolar epithelial barrier: Adhesion molecule mechanisms and impact of chemokines. J. Immunol. 164:427–435.

    PubMed  CAS  Google Scholar 

  • Sallusto, F., Geginat, J., and Lanzavecchia, A. (2004). Central memory and effector memory T cell subsets: Function, generation, and maintenance. Annu. Rev. Immunol. 22:745–763.

    Article  PubMed  CAS  Google Scholar 

  • Samuel, C.E. (1991). Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 183:1–11.

    Article  PubMed  CAS  Google Scholar 

  • Selye, H. (1936). A syndrome produced by diverse nocuous agents. Nature (London) 138:32.

    Google Scholar 

  • Sheridan, J.F., Feng, N.G., Bonneau, R.H., Allen, C.M., Huneycutt, B.S., and Glaser, R. (1991). Restraint stress differentially affects antiviral cellular and humoral immune responses in mice. J. Neuroimmunol. 31:245–255.

    Article  PubMed  CAS  Google Scholar 

  • Sprent, J., Zhang, X., Sun, S., and Tough, D. (2000). T-cell proliferation in vivo and the role of cytokines. Philos. Trans. R. Soc. London B Biol. Sci. 355:317–322.

    Article  PubMed  CAS  Google Scholar 

  • Stark, J., Avitsur, R., Padgett, D.A., and Sheridan, J.F. (2001). Social stress induces glucocorticoid resistance in macrophages. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280:R1799–R1805.

    PubMed  CAS  Google Scholar 

  • Stein-Streilein, J., and Guffee, J. (1986). In vivo treatment of mice and hamsters with antibodies to asialo GM1 increases morbidity and mortality to pulmonary influenza infection. J. Immunol. 136:1435–1441.

    PubMed  CAS  Google Scholar 

  • Stein-Streilein, J., Guffee, J., and Fan, W. (1988). Locally and systemically derived natural killer cells participate in defense against intranasally inoculated influenza virus. Regional Immunol. 1:100–105.

    CAS  Google Scholar 

  • Strieter, R.M., Belperio, J.A., and Keane, M.P. (2003). Host innate defenses in the lung: The role of cytokines. Curr. Opin. Infect. Dis. 16:193–198.

    PubMed  CAS  Google Scholar 

  • Tan, J.T., Dudl, E., LeRoy, E., Murray, R., Sprent, J., Weinberg, K.I., and Surh, C.D. (2001). IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc. Natl. Acad. Sci. U.S.A. 98:8732–8737.

    Article  PubMed  CAS  Google Scholar 

  • Tew, J.G., Mandel, T.E., Phipps, R.P., and Szakal, A.K. (1984). Tissue localization and retention of antigen in relation to the immune response. Am. J. Anat. 170:407–420.

    Article  PubMed  CAS  Google Scholar 

  • Tew, J.G., Wu, J., Fakher, M., Szakal, A.K., and Qin, D. (2001). Follicular dendritic cells: Beyond the necessity of T-cell help. Trends Immunol. 22:361–367.

    Article  PubMed  CAS  Google Scholar 

  • Topham, D.J., Tripp, R.A., and Doherty, P.C. (1997). CD8+ T cells clear influenza virus by perforin or Fas-dependent processes. J. Immunol. 159:5197–5200.

    PubMed  CAS  Google Scholar 

  • Tseng, R., Padgett, D.A., Dhabhar, F.S., Engler, H., and Sheridan, J.F. (2005). Stress-induced modulation of NK activity during influenza viral infection: Role of glucocorticoids and opioids. Brain Behav. Immun. 19:153–164.

    Article  PubMed  CAS  Google Scholar 

  • Walzer, T., Galibert, L., Comeau, M.R., and De Smedt, T. (2005). Plexin C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin-mediated adhesion and chemokine-induced migration. J. Immunol. 174:51–59.

    PubMed  CAS  Google Scholar 

  • Weber, K.S., von Hundelshausen. P., Clark-Lewis, I., Weber, P.C., and Weber, C. (1999). Differential immobilization and hierarchical involvement of chemokines in monocyte arrest and transmigration on inflamed endothelium in shear flow. Eur. J. Immunol. 29:700–712.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, X., Sun, S., Hwang, I., Tough, D.F., and Sprent, J. (1998). Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity 8: 591–599.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Michael T. Bailey
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  2. David A. Padgett
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  3. John F. Sheridan
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Editor information

Editors and Affiliations

  1. Departments of Veterinary Integrative Biosciences and Veterinary Pathobiology College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843-4458

    C. Jane Welsh

  2. Department of Psychology College of Liberal Arts, Texas A&M University, College Station, TX, 77843-4225

    Mary W. Meagher

  3. Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health National Institutes of Health, Rockville, MD, 20892-9401

    Esther M. Sternberg

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© 2006 Springer Science+Business Media, LLC

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Bailey, M.T., Padgett, D.A., Sheridan, J.F. (2006). Influenza Viral Infection: Stress-induced Modulation of Innate Resistance and Adaptive Immunity. In: Welsh, C.J., Meagher, M.W., Sternberg, E.M. (eds) Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-48334-4_8

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