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Hybrid Nanocomposites for Nanotechnology pp 707–768Cite as

Biomedical Applications of Organic–Inorganic Hybrid Nanoparticles

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Abstract

In this chapter, we discuss the application of various hybrid nanoparticles in different areas of biotechnology and biomedicine. The application of hybrid nanoparticles to these fields stems obviously from the intrinsic properties of nanoparticles (determined by high surface energy and large surface curvature) and also from the ability to design both the chemical nature of the nanoparticle surface (e.g., by attachment of organic moieties) and the nanoparticle structure (e.g., nanoparticle shape and surface structure). These features have allowed for the biocompatibility enhancement of the nanoparticles and hence, their routine use in contact with biogical entities, from the most simple proteins and biomolecules to the most complex living organisms. The first part of this review focuses on biosensors, with optical, electrochemical and magnetic detection systems. Then, exploiting magnetic properties, an entire section is devoted to nuclear magnetic resonance imaging and hyperthermia. Finally, the use of different hybrid nanocapsules for drug delivery purposes is discussed.

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Acknowledgements

The financial support of MEC (MAT2006–02394), CM (S-0505/PPQ-0316), and CSIC-PIF (200660F0111) and MAT2008-03224/NAN are gratefully acknowledged.

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Authors and Affiliations

  1. Instituto de Ciencia de Materiales de Madrid, CSIC, Campus Universitario de Cantoblanco, Madrid, 28049, Spain

    María C. Gutierrez, María L. Ferrer, Pedro Tartaj & Francisco del Monte

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  1. María C. Gutierrez
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  2. María L. Ferrer
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  3. Pedro Tartaj
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  4. Francisco del Monte
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Correspondence to María C. Gutierrez or Francisco del Monte .

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  1. CERAMEC, Limoges, France

    Lhadi Merhari

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Gutierrez, M. ., Ferrer, M.L., Tartaj, P., Monte, F. (2009). Biomedical Applications of Organic–Inorganic Hybrid Nanoparticles. In: Merhari, L. (eds) Hybrid Nanocomposites for Nanotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30428-1_15

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