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Patient-Specific Modeling in Tomorrow's Medicine pp 3–26Cite as

Reliable Patient-Specific Simulations of the Femur

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Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 09))

Abstract

Valuable simulations aimed at diagnosis and optimal treatment in clinical orthopedic practice should demonstrate that their results are verified, validated by experimental observations and obtained on a patient-specific level in a short time-scale. Such verified and validated simulations, based on CT-scans, were recently introduced using high-order finite element methods (p-FEMs), demonstrating an unprecedented prediction capability. We describe herein the methods used for creating p-FEM models of patient-specific femurs (including assignment of inhomogeneous material properties) and the large set of in-vitro experiments used to assess the validity of the simulation results. We thereafter extend the simulation capabilities for the analysis of bone fixations by metallic inserts, demonstrating again the high quality results. Such reliable patient-specific simulations are in an advanced stage to be used on a daily basis in clinical practice.

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Acknowledgements

We would like to thank Prof. Charles Milgrom from the Hadassah Hospital, Jerusalem, for femurs supply and his help with the CT-scans and experiments. Special thanks are extended to Mr. Alon Katz, a graduate student under the supervision of the first author, for his help with FE analyses and experiments. The authors gratefully acknowledge the generous support of the Technische Universität München–Institute for Advanced Study and International Graduate School of Science and Engineering, funded by the German Excellence Initiative, which made parts of this research possible.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Computational Mechanics Laboratory, Ben-Gurion University of the Negev, Beer Sheva, Israel

    Zohar Yosibash & Nir Trabelsi

Authors
  1. Zohar Yosibash
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  2. Nir Trabelsi
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Correspondence to Zohar Yosibash .

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Editors and Affiliations

  1. Fac. Engineering, Dept. Biomedical Engineering, Tel Aviv University, Ramat Aviv, 69978, Israel

    Amit Gefen

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Yosibash, Z., Trabelsi, N. (2011). Reliable Patient-Specific Simulations of the Femur. In: Gefen, A. (eds) Patient-Specific Modeling in Tomorrow's Medicine. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 09. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2011_89

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  • DOI: https://doi.org/10.1007/8415_2011_89

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  • Print ISBN: 978-3-642-24617-3

  • Online ISBN: 978-3-642-24618-0

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