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Recent Advances in Microparticle and Nanoparticle Delivery Vehicles for Mucosal Vaccination

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Book cover Mucosal Vaccines

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 354))

Abstract

The great potential of mucosal vaccination is widely accepted but progress in the clinical development of subunit mucosal vaccines has been disappointing. Of the available approaches, the use of polymer-based microparticles is attractive because these delivery vehicles can be specifically tailored for vaccines and they offer the potential for integration of adjuvant. Here we address recent developments in the use of particulates as mucosal vaccines and the potential of novel targeting strategies, formulation approaches and adjuvant combinations to enhance the efficacy of particle-based mucosal vaccines. This review discusses the current status of mucosal vaccines based on particles and highlights several of the strategies that are currently under investigation for improving their immunogenicity. These include enhancing the stability of formulations in the luminal environment, increasing uptake by specifically targeting particles to mucosal inductive sites, and augmenting immunogenicity through co-formulation with immunostimulatory agents.

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Acknowledgments

Edel McNeela is funded by Enterprise Ireland and Sigmoid Pharma through the Innovation Partnerships Programme (IP20090046). Ed Lavelle’s work on danger signals, mucosal immunity and vaccines is also funded by Science Foundation Ireland (08/RFP/BMT1363, 07/RFP/BICF537, 07/SRC/B1144), and the Meningitis Research Foundation (0610.0).

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  1. Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland

    E. A. McNeela & E. C. Lavelle

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  1. E. A. McNeela
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Correspondence to E. A. McNeela .

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  1. , Louisiana Gene Therapy Research Consorti, LSU Health Sciences Center, Poydras Street 1615, New Orleans, 70112, Louisiana, USA

    Pamela A. Kozlowski

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McNeela, E.A., Lavelle, E.C. (2011). Recent Advances in Microparticle and Nanoparticle Delivery Vehicles for Mucosal Vaccination. In: Kozlowski, P. (eds) Mucosal Vaccines. Current Topics in Microbiology and Immunology, vol 354. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2011_140

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