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Zinc, Cadmium, and Lead Resistance and Homeostasis

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Book cover Molecular Microbiology of Heavy Metals

Part of the book series: Microbiology Monographs ((MICROMONO,volume 6))

Abstract

Metals such as zinc are required for life but can be toxic in excess. Other metals such as cadmium and lead have almost no known biological function, and can lead to cell damage and death even at low concentrations. Interestingly, all three metals are often recognized by the same gene regulators and membrane transporters. Therefore, an examination of the inherent chemical properties of these three metal ions is essential in understanding the basis of metal specificity displayed by target proteins responsible for metal homeostasis and resistance. The relationship between the chemical properties of these metals and similarities in structural responses they may elicit are discussed. The core elements regulating uptake, efflux, and sequestration of these metals are described and interpreted both biologically and chemically. Additional mechanisms aiding cell survival, such as precipitation of metal salts on the cell surface, are also mentioned.

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Authors and Affiliations

  1. Department of Soil, Water, and Environmental Science, University of Arizona, Shantz Bldg #38, Rm 429, P.O. Box 210038, 85721, Tucson, AZ, USA

    Christopher Rensing

  2. Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 E. Canfield Avenue, 48201, Detroit, MI, USA

    Bharati Mitra

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Correspondence to Christopher Rensing .

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Dietrich H. Nies Simon Silver

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Rensing, C., Mitra, B. (2007). Zinc, Cadmium, and Lead Resistance and Homeostasis. In: Nies, D.H., Silver, S. (eds) Molecular Microbiology of Heavy Metals. Microbiology Monographs, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7171_2006_083

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