Abstract
Multicomponent reactions (MCRs) are of great significance in organic synthesis. They often decrease the number of synthesis steps since three or more reactants are incorporated in the product in a single step. This increases the number of combinatorial options and allows more efficient processes in less time. The pharmaceutical industry is therefore very fond of MCRs for the construction of libraries. As a consequence, the field is being investigated intensely for the enhancement of chemical processes and the discovery of new types of MCRs.
The combination of the benefits of flow technology and MCRs for heterocycle synthesis is an interesting and specialized field. This chapter serves as an overview of the literature covering this topic starting from 2010, up to when the literature on this matter is reviewed in a book chapter in this book series by Cukalovic et al. (Top Heterocycl Chem 23:161–198, 2010).
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Abbreviations
- 2-MeTHF:
-
2-Methyltetrahydrofuran
- AcOH:
-
Acetic acid
- Boc:
-
tert-Butoxycarbonyl
- BPR:
-
Back-pressure regulator
- DBU:
-
1,8-Diazabicyclo[5.4.0]undec-7-ene
- DCM:
-
Dichloromethane
- DIPEA:
-
N,N-Diisopropylethylamine
- DMA:
-
N,N-Dimethylacetamide
- DMAP:
-
4-Dimethylaminopyridine
- DME:
-
1,2-Dimethoxyethane
- DMF:
-
N,N-Dimethylformamide
- EDC:
-
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide
- eq:
-
Equivalents
- Et2O:
-
Diethyl ether
- Et3N:
-
Triethylamine
- EtOAc:
-
Ethyl acetate
- EtOH:
-
Ethanol
- HOBt:
-
1-Hydroxybenzotriazole
- kHz:
-
Kilohertz
- M:
-
Molar
- MCR:
-
Multicomponent reaction
- MeCN:
-
Acetonitrile
- MeOH:
-
Methanol
- MW:
-
Microwave
- PEG200:
-
Polyethylene glycol 200
- PEG300:
-
Polyethylene glycol 300
- PFA:
-
Perfluoroalkoxy alkane
- psi:
-
Pound-force per square inch
- PTFE:
-
Polytetrafluoroethylene (Telfon®)
- t-BuONO:
-
tert-Butyl nitrite
- TMSN3 :
-
Trimethylsilyl azide
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Van Mileghem, S., Veryser, C., De Borggraeve, W.M. (2018). Flow-Assisted Synthesis of Heterocycles via Multicomponent Reactions. In: Sharma, U., Van der Eycken, E. (eds) Flow Chemistry for the Synthesis of Heterocycles. Topics in Heterocyclic Chemistry, vol 56. Springer, Cham. https://doi.org/10.1007/7081_2018_23
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DOI: https://doi.org/10.1007/7081_2018_23
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