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DNA Alterations and Cellular Damage Induced by Non-steroidal Anti-inflammatories on Different Species of Fish

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Book cover Non-Steroidal Anti-Inflammatory Drugs in Water

Part of the book series: The Handbook of Environmental Chemistry ((HEC,volume 96))

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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs used to reduce inflammation, pain, and fever by inhibiting the enzyme cyclooxygenase (COX 1 and COX 2). These drugs have been positioned among the most consumed worldwide. After their biotransformation in the body, they are eliminated as metabolites, and also in the environment they can undergo transformations, generating products that are more toxic than the original molecule. Several studies have shown that NSAIDs are not eliminated in conventional treatments used by wastewater treatment plants and represent a continuous contribution to the environment, causing significant effects on biota. However, there has been little attention given to the study of its toxic effects on aquatic organisms. The objective of this chapter is to review, compile, and analyze the oxidative damage induced by NSAIDs in different aquatic organisms, to evaluate the ecotoxicological effects of this type of drugs.

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Author information

Authors and Affiliations

  1. Laboratory of Molecular Toxicology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico

    Nely SanJuan-Reyes & Ricardo Pérez-Pastén Borja

  2. Laboratory of Environmental Toxicology, Facultad de Química, Universidad Autónoma del Estado de México, Toluca, Mexico

    Leobardo Manuel Gómez-Oliván & Hariz Islas-Flores

  3. Laboratory of Aquatic Toxicology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico

    Marcela Galar-Martínez & Sandra García-Medina

Authors
  1. Nely SanJuan-Reyes
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  2. Leobardo Manuel Gómez-Oliván
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  3. Ricardo Pérez-Pastén Borja
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  4. Hariz Islas-Flores
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  5. Marcela Galar-Martínez
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  6. Sandra García-Medina
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Correspondence to Nely SanJuan-Reyes .

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Editors and Affiliations

  1. Environmental Toxicology Lab, Faculty of Chemistry, Autonomous University of the State of Mexico, Toluca, Estado de México, Mexico

    Leobardo Manuel Gómez-Oliván

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SanJuan-Reyes, N., Gómez-Oliván, L.M., Pérez-Pastén Borja, R., Islas-Flores, H., Galar-Martínez, M., García-Medina, S. (2020). DNA Alterations and Cellular Damage Induced by Non-steroidal Anti-inflammatories on Different Species of Fish. In: Gómez-Oliván, L.M. (eds) Non-Steroidal Anti-Inflammatory Drugs in Water. The Handbook of Environmental Chemistry, vol 96. Springer, Cham. https://doi.org/10.1007/698_2020_544

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