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Sphingolipid Biology pp 363–381Cite as

Sphingolipids and Cancer

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Summary

Sphingolipids regulate processes that are dysregulated in cancer such as cell growth and death, adhesion and motility. Changes in sphingolipid metabolism in cancer cells that result in an altered sphingolipid composition may contribute to unlimited proliferation in cancer cells and aide progression, invasion and metastasis. Thus, exogenous sphingolipid metabolites such as ceramides and sphingoid bases have been used both in vivo and in vitro to reverse aberrant cell behavior and suppress tumorigenesis. Here we review the role of sphingolipids and sphingolipid metabolites in cancer development, prevention and treatment.

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Authors and Affiliations

  1. Karmanos Cancer Institute, Wayne State University School of Medicine, HWCRC 608, 110 E. Warren Avenue, Detroit, MI, 48201, USA

    Eva M. Schmelz & Holly Symolon

  2. School of Biology and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA

    Eva M. Schmelz & Holly Symolon

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  1. Eva M. Schmelz
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  2. Holly Symolon
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Editors and Affiliations

  1. Brain Science Institute, The Institute of Physical and Chemical Research (Riken), 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    Yoshio Hirabayashi

  2. Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science and Graduate School of Life Science, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan

    Yasuyuki Igarashi

  3. School of Biology and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA

    Alfred H. Merrill Jr.

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© 2006 Springer-Verlag Tokyo

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Schmelz, E.M., Symolon, H. (2006). Sphingolipids and Cancer. In: Hirabayashi, Y., Igarashi, Y., Merrill, A.H. (eds) Sphingolipid Biology. Springer, Tokyo. https://doi.org/10.1007/4-431-34200-1_29

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