Skip to main content
SpringerLink
Log in

Ribonucleotide reductases — a group of enzymes with different metallosites and a similar reaction mechanism

  • Chapter
  • First Online:
Metal Sites in Proteins and Models

Part of the book series: Structure and Bonding ((4143,volume 88))

Abstract

Ribonucleotide reductases catalyze an essential reaction in all living cells — the production of deoxyribonucleotide precursors for DNA synthesis. An intricate allosteric regulation enables one and the same enzymic component to accept both purine and pyrimidine ribonucleotide substrates and to furnish growing cells with balanced deoxyribonucleotide pools. The reaction, which is based on radical chemistry, is common to all ribonucleotide reductases, whereas the mode of furnishing the radical differs and is currently a basis for distinguishing at least three different classes of ribonucleotide reductases. The radical generating components, although of seemingly different evolutionary origin, all include transition metal binding sites. Studies on the ribonucleotide reductase family highlight exciting mechanistic and evolutionary implications of far-reaching significance.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lin AL, Elford HL (1980) J Biol Chem 255:8523–8528

    PubMed  CAS  Google Scholar 

  2. Markert ML (1991) Immunodefic Rev 3:45–81

    PubMed  CAS  Google Scholar 

  3. Caras IW, Martin DWJ (1988) Mol Cell Biol 8:2698–2704

    PubMed  CAS  Google Scholar 

  4. Nocentini G (1996) Crit Rev Oncol Hematol 22:89–126

    PubMed  CAS  Google Scholar 

  5. Reichard P (1989) Biochim Biophys Acta 1000:49–50

    PubMed  CAS  Google Scholar 

  6. Reichard P (1995) Annu Rev Biochem 64:1–28

    PubMed  CAS  Google Scholar 

  7. Blakley RL, Orme-Johnson WH, Bozdech JM (1979) Biochemistry 18:2335–2339

    PubMed  CAS  Google Scholar 

  8. Gleason FK, Hogenkamp HP (1972) Biochim Biophys Acta 277:466–470

    PubMed  CAS  Google Scholar 

  9. Schimpff WG, Follmann H, Auling G (1981) Biochem Biophys Res Commun 102:1276–1282

    Google Scholar 

  10. Willing A, Follmann H, Auling G (1988) Eur J Biochem 170:603–611

    PubMed  CAS  Google Scholar 

  11. Fontecave M, Eliasson R, Reichard P (1989) Proc Natl Acad Sci USA 86:2147–2151

    PubMed  CAS  Google Scholar 

  12. Sun XY, Ollagnier S, Schmidt PP, Atta M, Mulliez E, Lepape L, Eliasson R, Gräslund A, Fontecave M, Reichard P, Sjöberg BM (1996) J Biol Chem 271:6827–6831

    PubMed  CAS  Google Scholar 

  13. Bult CJ, White O, Olsen GJ, Zhou L, Fleischmann RD, Sutton GG, Blake JA, FitzGerald LM, Clayton RA, Gocayne JD, Kerlavage AR, Dougherty BA, Tomb JF, Adams MD, Reich CI, Overbeek R, Kirkness EF, Weinstock KG, Merrick JM, Glodek A, Scott JL, Geoghagen NSM, Weidman JF, Fuhrmann JL, Venter JC et al. (1996) Science 273:1058–1073

    PubMed  CAS  Google Scholar 

  14. Riera J, Robb FT, Weiss R, Fontecave M (1996) Proc Natl Acad Sci USA 94:475–478

    Google Scholar 

  15. Tauer A, Benner SA (1996) Proc Natl Acad Sci USA 94:53–58

    Google Scholar 

  16. Petersson L, Gräslund A, Ehrenberg A, Sjöberg B-M, Reichard P (1980) J Biol Chem 255:6706–6712

    PubMed  CAS  Google Scholar 

  17. Nordlund P, Sjöberg B-M, Eklund H (1990) Nature 345:593–598

    PubMed  CAS  Google Scholar 

  18. Nordlund P, Eklund H (1993) J Mol Biol 232:123–164

    PubMed  CAS  Google Scholar 

  19. Ollagnier S, Mulliez E, Gaillard J, Eliasson R, Fontecave M, Reichard P (1996) J Biol Chem 271:9410–9416

    PubMed  CAS  Google Scholar 

  20. Griepenburg U, Lassmann G, Auling G (1996) Free Radical Res 24:473–481

    CAS  Google Scholar 

  21. Gerfen GJ, Licht S, Willems JP, Hoffman BM, Stubbe J (1996) J Am Chem Soc 118:8192–8197

    CAS  Google Scholar 

  22. Åberg A, Hahne S, Karlsson M, Larsson A, Ormö M, Åhgren A, Sjöberg B-M (1989) J Biol Chem 264:12249–12252

    PubMed  Google Scholar 

  23. Mao SS, Yu GX, Chalfoun D, Stubbe J (1992) Biochemistry 31:9752–9759

    PubMed  CAS  Google Scholar 

  24. Stubbe J, Ator M, Krenitsky T (1983) J Biol Chem 258:1625–1631

    PubMed  CAS  Google Scholar 

  25. Mao SS, Holler TP, Yu GX, Bollinger JM, Booker S, Johnston MI, Stubbe J (1992) Biochemistry 31:9733–9743

    PubMed  CAS  Google Scholar 

  26. Ashley GW, Harris G, Stubbe J (1986) J Biol Chem 261:3958–3964

    PubMed  CAS  Google Scholar 

  27. Sjöberg B-M, Gräslund A, Eckstein F (1983) J Biol Chem 258:8060–8067

    PubMed  Google Scholar 

  28. Behravan G, Sen S, Rova U, Thelander L, Eckstein F, Gräslund A (1995) BBA-Gene Struct Express 1264:323–329

    Google Scholar 

  29. van der Donk WA, Stubbe J, Gerfen GJ, Bellew BF, Griffin RG (1995) J Am Chem Soc 117:8908–8916

    Google Scholar 

  30. Covés J, Defallois LLH, Lepape L, Decout JL, Fontecave M (1996) Biochemistry 35:8595–8602

    PubMed  Google Scholar 

  31. van der Donk WA, Zeng CH, Biemann K, Stubbe J, Hanlon A, Kyte J (1996) Biochemistry 35:10058–10067

    PubMed  Google Scholar 

  32. Holmgren A, Björnstedt, M (1995) In: Packer L (ed) Biothiols, Vol 252, pp 199–208 Academic Press Inc, San Diego, CA 92101–4495

    Google Scholar 

  33. Holmgren A, Åslund F (1995) In: Packer L (ed) Biothiols, Vol 252, pp 283–292 Academic Press Inc, San Diego, CA 92101–4495

    Google Scholar 

  34. Uhlin U, Eklund H (1994) Nature 370:533–539

    PubMed  CAS  Google Scholar 

  35. Reichard P (1993) Science 260:1773–1777

    PubMed  CAS  Google Scholar 

  36. Sjöberg B-M (1995) In: Eckstein F, Lilley DMJ (eds) Nucl Acids Mol Biol, Vol 9, pp 192–221 Springer, Berlin Heidelberg New york

    Google Scholar 

  37. Uhlin U, Eklund H (1996) J Mol Biol 262:358–369

    PubMed  CAS  Google Scholar 

  38. Ormö M, Sjöberg B-M (1996) Eur J Biochem 241:363–367

    PubMed  Google Scholar 

  39. Eriksson M, Uhlin U Ramaswamy S, Ekberg M, Regnström K, Sjöberg B-M, Eklund H (1997) Structure

    Google Scholar 

  40. Nielsen BB, Kauppi B, Thelander M, Thelander L, Kjøller Larsen I, Eklund H (1995) FEBS Lett 373:310–312

    PubMed  CAS  Google Scholar 

  41. Kauppi B, Nielsen BA, Ramaswamy S, Kjøller Larsen I, Thelander M, Thelander L, Eklund H (1996) J Mol Biol 262:706–720

    PubMed  CAS  Google Scholar 

  42. Ehrenberg A, Reichard P (1972) J Biol Chem 247:3485–3488

    PubMed  CAS  Google Scholar 

  43. Larsson A, Sjöberg BM (1986) EMBO J 5:2037–2040

    PubMed  CAS  Google Scholar 

  44. Sjöberg BM (1994) Structure 2:793–796

    PubMed  Google Scholar 

  45. Climent I, Sjöberg B-M, Huang CY (1992) Biochemistry 31:4801–4807

    PubMed  CAS  Google Scholar 

  46. Persson BO, Karlsson M, Climent I, Ling J, Sanders-Loehr J, Sahlin M, Sjöberg B-M (1996) J Biol Inorg Chem 1:247–256

    CAS  Google Scholar 

  47. Ekberg M, Sahlin M, Eriksson M, Sjöberg BM (1996) J Biol Chem 271:20655–20659

    PubMed  CAS  Google Scholar 

  48. Rova U, Goodtzova K, Ingemarson R, Behravan G, Gräslund A, Thelander L (1995) Biochemistry 34:4267–4275

    PubMed  CAS  Google Scholar 

  49. Jordan A, Pontis E, Atta M, Krook M, Gibert I, Barbé J Reichard P (1994) Proc Natl Acad Sci USA 91:12892–12896

    PubMed  CAS  Google Scholar 

  50. Jordan A, Gibert I, Barbé J (1995) Gene 167:75–79

    PubMed  CAS  Google Scholar 

  51. Jordan A, Pontis E, Åslund F, Hellman U, Gibert I, Reichard P (1996) J Biol Chem 271: 8779–8785

    PubMed  CAS  Google Scholar 

  52. Fraser CM, Gocayne JD, White O, Adams MD, Clayton RA, Fleischmann RD, Bult CJ, Kerlavage AR, Sutton G, Kelley JM, Fritchman JL, Weidman JF, Small KV, Sandusky M, Fuhrmann J, Nguyen D, Utterback TR, Saudek DM, Phillips CA, Merrick JM, Tomb JF, Dougherty BA, Bott KF, Hu PC, Lucier TS, Peterson SN, Smith HO, Hutchison CA, Venter JC (1995) Science 270:397–403

    PubMed  CAS  Google Scholar 

  53. Tulokhonova L, Torrents Serra E, Jordan A, Gibert I, Hellman U, Barbé J, Karlsson M, Sjöberg B-M (1997) Manuscript

    Google Scholar 

  54. Booker, S Stubbe, J (1993) Proc Natl Acad Sci U S A 90: 8352–8356

    PubMed  CAS  Google Scholar 

  55. Hatfull GF, Sarkis GJ (1993) Mol Microbiol 7:395–405

    PubMed  CAS  Google Scholar 

  56. Hogenkamp HPC, McFarlan SC (1989) In: Cory JG, Cory AH, (eds) Inhibitors of ribonucleoside diphosphate reductase activity, pp 17–36 Pergamon Press, Inc, Exeter, UK

    Google Scholar 

  57. Kaneko T, Sato S, Kotani H, Tanaka A, Asamizu E, Nakamura Y, Miyajima N, Hirosawa M, Sugiura M, Sasamoto S, Kimura T, Hosouchi T, Matsuno A, Muraki A, Nakazaki N, Naruo K, Okumura S, Shimpo S, Takeuchi C, Wada T, Watanabe A, Yamada M, Yasuda M, Tabata S (1996) DNA Res 3:109–136

    PubMed  CAS  Google Scholar 

  58. Booker S, Licht S, Broderick J, Stubbe J (1994) Biochemistry 33:12676–12685

    PubMed  CAS  Google Scholar 

  59. Sun X, Harder J, Krook M, Jörnvall H, Sjöberg BM, Reichard P (1993) Proc Natl Acad Sci USA 90:577–581

    PubMed  CAS  Google Scholar 

  60. Young P, Ohman M, Xu MQ, Shub DA, Sjöberg BM (1994) J Biol Chem 269:20229–20232

    PubMed  CAS  Google Scholar 

  61. Young P, Ohman M, Sjöberg BM (1994) J Biol Chem 269:27815–27818

    PubMed  CAS  Google Scholar 

  62. Young P, Andersson J, Sahlin M, Sjöberg BM (1996) J Biol Chem 271:20770–20775

    PubMed  CAS  Google Scholar 

  63. Eliasson R, Pontis E, Sun XY, Reichard P (1994) J Biol Chem 269:26052–26057

    PubMed  CAS  Google Scholar 

  64. Harder J, Eliasson R, Pontis E, Ballinger MD, Reichard P (1992) J Biol Chem 267:25548–25552

    PubMed  CAS  Google Scholar 

  65. Bianchi V, Reichard P, Eliasson R, Pontis E, Krook M, Jörnvall H, Haggård-Ljungquist E (1993) J Bacteriol 175:1590–1595

    PubMed  CAS  Google Scholar 

  66. Mulliez E, Ollagnier S, Fontecave M, Eliasson R, Reichard P (1995) Proc Natl Acad Sci USA 92:8759–8762

    PubMed  CAS  Google Scholar 

  67. Wagner AF, Frey M, Neugebauer FA, Schäfer W, Knappe J (1992) Proc Natl Acad Sci USA 89:996–1000

    PubMed  CAS  Google Scholar 

  68. Frey M, Rothe M, Wagner AFV, Knappe J (1994) J Biol. Chem 269:12432–12437

    PubMed  CAS  Google Scholar 

  69. Knappe J, Wagner AFV (1995) In: Klinman JP (ed) Redox — Active Amino Acids in Biology, Vol 258, pp 343–362 Academic Press, San Diego, CA 92101–4495

    Google Scholar 

  70. Parast CV, Wong KK, Kozarich JW, Peisach J, Magliozzo RS (1995) Biochemistry 34:5712–5717

    PubMed  CAS  Google Scholar 

  71. Parast CV, Wong KK, Kozarich JW, Peisach J, Magliozzo RS (1995) J Am Chem Soc 117:10601–10602

    CAS  Google Scholar 

  72. Atkin CL, Thelander L, Reichard P, Lang G (1973) J Biol Chem 248:7464–7472

    PubMed  CAS  Google Scholar 

  73. Nordlund P, Eklund H (1995) Curt Opin Struct Biol 5:758–766

    CAS  Google Scholar 

  74. Andersson KK, Gräslund A (1995) Adv Inorg Chem 43:359–407

    CAS  Google Scholar 

  75. Silva KE, Elgren TE, Que L, Stankovich MT (1995) Biochemistry 34:14093–14103

    PubMed  CAS  Google Scholar 

  76. Sahlin M, Lassmann G, Pötsch S, Sjöberg BM, Gräslund A (1995) J Biol Chem 270:12361–12372

    PubMed  CAS  Google Scholar 

  77. Tong WH, Chen S, Lloyd SG, Edmondson DE, Huynh BH, Stubbe J (1996) J Am Chem Soc 118:2107–2108

    CAS  Google Scholar 

  78. Backes G, Sahlin M, Sjöberg BM, Loehr TM, Sanders-Loehr J (1989) Biochemistry 28:1923–1929

    PubMed  CAS  Google Scholar 

  79. Ormö M, Regnström K, Wang ZG, Que L, Sahlin M, Sjöberg BM (1995) J Biol Chem 270:6570–6576

    PubMed  Google Scholar 

  80. Kjøller Larsen I, Sjöberg BM, Thelander L (1982) Eur J Biochem 125:75–81

    Google Scholar 

  81. Pötsch S, Drechsler H, Liermann B, Gräslund A, Lassmann G (1994) Mol Pharmacol 45:792–796

    PubMed  Google Scholar 

  82. Pötsch S, Sahlin M, Langelier Y, Gräslund A, Lassmann G (1995) FEBS Lett 374:95–99

    PubMed  Google Scholar 

  83. Åberg A, Nordlund P, Eklund H (1993) Nature 361:276–278

    PubMed  Google Scholar 

  84. Logan DT, Su XD, Åberg A, Regnström K, Hajdu J, Eklund H, Nordlund, P (1996) Structure 4:1053–1064

    PubMed  CAS  Google Scholar 

  85. Sahlin M, Gräslund A, Petersson L, Ehrenberg A, Sjöberg BM (1989) Biochemistry 28:2618–2625

    PubMed  CAS  Google Scholar 

  86. Covés J, Fontecave M (1993) Eur J Biochem 211:635–641

    PubMed  Google Scholar 

  87. Fontecave M, Eliasson R, Reichard P (1987) J Biol Chem 262:12325–12331

    PubMed  CAS  Google Scholar 

  88. Su X-D, Persson B-O, Sjöberg B-M, Nordlund P (1996) Biochemistry Manuscript

    Google Scholar 

  89. Atta M, Andersson KK, Ingemarson R, Thelander L, Gräslund A (1994) J Am Chem Soc 116: 6429–6430

    CAS  Google Scholar 

  90. Gerez C, Gaillard J, Latour J-M, Fontecave M (1991) Angew Chem Int Ed Eng 30:1135–1136

    Google Scholar 

  91. Gerez C, Fontecave M (1992) Biochemistry 31:780–786

    PubMed  CAS  Google Scholar 

  92. Hendrich MP, Elgren TE, Que LJ (1991) Biochem Biophys Res Commun 176:705–710

    PubMed  CAS  Google Scholar 

  93. Davydov R, Kuprin S, Gräslund A, Ehrenberg A (1994) J Am Chem Soc 116:11120–11128

    CAS  Google Scholar 

  94. Davydov R, Sahlin M, Kuprin S, Gräslund A, Ehrenberg A (1996) Biochemistry 35:5571–5576

    PubMed  CAS  Google Scholar 

  95. Davydov RM, Ménage S, Fontecave M, Gräslund A, Ahrenberg A (1997) Inorg Chem in press

    Google Scholar 

  96. Ling JS, Sahlin M, Sjöberg B-M, Loehr TM, Sanders-Loehr J (1994) J Biol Chem 269:5595–5601

    PubMed  CAS  Google Scholar 

  97. Bollinger JM, Tong WH, Ravi N, Huynh BH, Edmondson DE, Stubbe J (1994) J Am Chem Soc 116:8015–8023

    CAS  Google Scholar 

  98. Bender CJ, Sahlin M, Babcock GT, Barry BA, Chandrashekar TK, Salowe SP, Stubbe J, Lindström B, Petersson L, Ehrenberg A, Sjöberg BM (1989) J Am Chem Soc 111:8076–8083

    CAS  Google Scholar 

  99. Hoganson CW, Sahlin M, Sjöberg BM, Babcock GT (1996) J Am Chem Soc 118:4672–4679

    CAS  Google Scholar 

  100. Himo F, Gräslund A, Eriksson LA (1997) Biophys J 72:1556–1567

    PubMed  CAS  Google Scholar 

  101. Schmidt PP, Andersson KK, Barra AL, Thelander L, Gräslund A (1996) J Biol Chem 271:23615–23618

    PubMed  CAS  Google Scholar 

  102. Allard P, Barra AL, Andersson KK, Schmidt PP, Atta M, Gräslund A (1996) J Am Chem Soc 118:895–896

    CAS  Google Scholar 

  103. Sahlin M, Lassmann G, Pötsch S, Slaby A, Sjöberg B-M, Gräslund A (1994) J Biol Chem 269:11699–11702

    PubMed  CAS  Google Scholar 

  104. Ravi N, Bollinger JM, Huynh BH, Edmondson DE, Stubbe J (1994) J Am Chem Soc 116:8007–8014

    CAS  Google Scholar 

  105. Bollinger JM, Tong WH, Ravi N, Huynh BH, Edmondson DE, Stubbe J (1994) J Am Chem Soc 116:8024–8032

    CAS  Google Scholar 

  106. Burdi D, Sturgeon BE, Tong WH, Stubbe JA, Hoffman BM (1996) J Am Chem Soc 118:281–282

    CAS  Google Scholar 

  107. Sturgeon BE, Burdi D, Chen SX, Huynh BH, Edmondson DE, Stubbe J, Hoffman BM (1996) J Am Chem Soc 118:7551–7557

    CAS  Google Scholar 

  108. Schmidt PP, Rova U, Katterle B, Thelander L, Grdslund A (1997) J Biol Chem

    Google Scholar 

  109. Rosenzweig AC, Frederick CA, Lippard SJ, Nordlund P (1993) Nature 366:537–543

    PubMed  CAS  Google Scholar 

  110. Frolow F, Kalb AJ, Yariv J (1994) Nat Struct Biol 1:453–460

    PubMed  CAS  Google Scholar 

  111. LeBrun N, Wilson MT, Andrews SC, Guest JR, Harrison PM, Thomson AJ, Moore GR (1993) FEBS Lett 333:197–202

    CAS  Google Scholar 

  112. deMaré F, Kurtz DM, Nordlund P (1996) Nature Struct Biology 3:539–546

    Google Scholar 

  113. Lindqvist Y, Huang WJ, Schneider G, Shanklin J (1996) EMBO J 15:4081–4092

    PubMed  CAS  Google Scholar 

  114. Lendzian F, Sahlin M, Macmillan F, Bittl R, Fiege R, Pötsch S, Sjöberg BM, Gräslund A, Lubitz W, Lassmann G (1996) J Am Chem Soc 118:8111–8120

    CAS  Google Scholar 

  115. Katterle B, Sahlin M, Schmidt PP, Pötsch S, Logan D, Gräslund A, Sjöberg B-M (1997) J Biol Chem 272:10414–10421

    PubMed  CAS  Google Scholar 

  116. Ormö M, deMaré F, Regnström K, Åberg A, Sahlin M, Ling J, Loehr TM, Sanders-Loehr J, Sjöberg BM (1992) J Biol Chem 267:8711–8714

    PubMed  Google Scholar 

  117. Åberg A, Ormö M, Nordlund P, Sjöberg BM (1993) Biochemistry 32:9845–9850

    PubMed  Google Scholar 

  118. Logan D, Persson BO, Sjöberg B-M, Nordlund P (1997) Manuscript

    Google Scholar 

  119. Atta M, Nordlund P, Åberg A, Eklund H, Fontecave M (1992) J Biol Chem 267:20682–20688

    PubMed  CAS  Google Scholar 

  120. Elgren TE, Ming LJ, Que LJ (1994) J Am Chem Soc 33:891–894

    CAS  Google Scholar 

  121. Mulliez E, Fontecave M, Gaillard J, Reichard P (1993) J Biol Chem 268:2296–2299

    PubMed  CAS  Google Scholar 

  122. Sun XY, Eliasson R, Pontis E, Andersson J, Buist G, Sjöberg BM, Reichard P (1995) J Biol Chem 270:2443–2446

    PubMed  CAS  Google Scholar 

  123. Lazazzera BA, Beinert H, Khoroshilova N, Kennedy MC, Kiley PJ (1996) J Biol Chem 271:2762–2768

    PubMed  CAS  Google Scholar 

  124. Wong KK, Murray BW, Lewisch SA, Baxter MK, Ridky TW, Ulissi-DeMario L, Kozarich JW (1993) Biochemistry 32:14102–14110

    PubMed  CAS  Google Scholar 

  125. Knappe J, Sawers G (1990) Ferns Microbiol Rev 6:383–398

    CAS  Google Scholar 

  126. Broderick JB, Duderstadt RE, Fernandez DC, Wojtuszewski K, Henshaw TF, Johnson MK (1997) J Am Chem Soc, in press

    Google Scholar 

  127. Orme-Johnson WH, Beinert H, Blakley RL (1974) J Biol Chem 249:2338–2343

    PubMed  CAS  Google Scholar 

  128. Licht S, Gerfen GJ, Stubbe JA (1996) Science 271:477–481

    PubMed  CAS  Google Scholar 

  129. Ludwig ML, Drennan CL, Matthews RG (1996) Structure 4:505–512

    PubMed  CAS  Google Scholar 

  130. Drennan CL, Huang S, Drummond JT, Matthews RG, Ludwig ML (1994) Science 266:1669–674

    PubMed  CAS  Google Scholar 

  131. Mancia F, Evans PR (1996) Structure 4:339–350

    PubMed  CAS  Google Scholar 

  132. Nesheim JC, Lipscomb JD (1996) Biochemistry 35:0240–10247

    Google Scholar 

  133. Sjöberg BM, Hahne S, Mathews CZ, Mathews CK, Rand KN, Gait MJ (1986) EMBO J 5:2031–2036

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Biology, Stockholm University, S-10691, Stockholm, Sweden

    B. -M. Sjöberg

Authors
  1. B. -M. Sjöberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

H. A. O. Hill P. J. Sadler A. J. Thomson

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Verlag

About this chapter

Cite this chapter

Sjöberg, B.M. (1997). Ribonucleotide reductases — a group of enzymes with different metallosites and a similar reaction mechanism. In: Hill, H.A.O., Sadler, P.J., Thomson, A.J. (eds) Metal Sites in Proteins and Models. Structure and Bonding, vol 88. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-62870-3_5

Download citation

  • DOI: https://doi.org/10.1007/3-540-62870-3_5

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-62870-5

  • Online ISBN: 978-3-540-69035-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation