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Extracellular MRI Contrast Agents Based on Gadolinium

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Contrast Agents I

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 221))

Abstract

A summary of the development of extracellular MRI contrast agents during the last twenty years is given. Focal points are chemistry, physico-chemical properties and pharmacokinetic behaviour of gadolinium complexes. The synthesis of acyclic and macrocyclic ligands is described, particularly of derivatives of the ligands DTPA and DOTA. Stability, relaxivity and formulations of the gadolinium complexes are issues of special interest as well as their toxicological and clinical aspects. An outlook on the future development of clinically useful extracellular MRI contrast agents is provided.

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Author information

Authors and Affiliations

  1. Contrast Media Research, Schering AG, Muellerstrasse 178, 13342, Berlin, Germany

    H. Gries

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  1. H. Gries
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Editors and Affiliations

  1. International Project Management Therapeutics, Schering AG, 13342, Berlin, Germany

    Werner Krause

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© 2002 Springer-Verlag Berlin Heidelberg

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Gries, H. (2002). Extracellular MRI Contrast Agents Based on Gadolinium. In: Krause, W. (eds) Contrast Agents I. Topics in Current Chemistry, vol 221. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45733-X_1

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  • DOI: https://doi.org/10.1007/3-540-45733-X_1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42247-1

  • Online ISBN: 978-3-540-45733-6

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